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Listen "ECG Abnormalities Predict Heart Failure Risk 11/19/25"
Episode Synopsis
Welcome to Cardiology Today – Recorded November 19, 2025. This episode summarizes 5 key cardiology studies on topics like heart failure and stroke. Key takeaway: ECG Abnormalities Predict Heart Failure Risk.
Article Links:
Article 1: Isolated non-specific electrocardiographic ST-T abnormalities and risk of incident heart failure and its subtypes. (Heart (British Cardiac Society))
Article 2: Estimating 5-year absolute risk of cardiovascular disease using routinely collected electronic medical records from Australian general practices. (Heart (British Cardiac Society))
Article 3: Comparing diagnostic tools for heart failure with preserved ejection fraction across community and clinical cohorts. (Heart (British Cardiac Society))
Article 4: Therapy gaps for patients with heart failure and reduced kidney function: A prospective cohort study. (ESC heart failure)
Article 5: Impact of Left Atrial v-Wave Following Mitral Edge-to-Edge Repair on Survival: The MITRA-PRO Registry. (Journal of the American Heart Association)
Full episode page: https://podcast.explainheart.com/podcast/ecg-abnormalities-predict-heart-failure-risk-11-19-25/
Featured Articles
Article 1: Isolated non-specific electrocardiographic ST-T abnormalities and risk of incident heart failure and its subtypes.
Journal: Heart (British Cardiac Society)
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41249037
Summary: Isolated non-specific S. T. T. abnormalities on electrocardiograms were found to be associated with an increased risk of incident coronary heart disease and stroke in participants free of these conditions at baseline. This study also found that these abnormalities were linked to an increased risk of incident heart failure and its subtypes. Data showed that these specific electrocardiographic patterns, defined by Minnesota E. C. G. classification, independently predicted future development of heart failure, including both heart failure with preserved ejection fraction and heart failure with reduced ejection fraction. These findings establish a prognostic role for isolated non-specific S. T. T. abnormalities in identifying individuals at risk for future cardiovascular events and heart failure.
Article 2: Estimating 5-year absolute risk of cardiovascular disease using routinely collected electronic medical records from Australian general practices.
Journal: Heart (British Cardiac Society)
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41249035
Summary: This study demonstrated the feasibility and performance of using routinely collected electronic medical records from Australian general practices to estimate the 5-year absolute risk of cardiovascular disease. Researchers found that integrating primary care electronic medical record data, specifically from the New South Wales Health Lumos program, provided a viable approach for cardiovascular risk prediction. The study successfully utilized data from 680 general practices to assess the predictive capability of these records. These findings indicate that Australian healthcare systems can effectively leverage existing electronic medical records for robust cardiovascular disease risk estimation, comparable to methods used in the U. S. A. and U. K.
Article 3: Comparing diagnostic tools for heart failure with preserved ejection fraction across community and clinical cohorts.
Journal: Heart (British Cardiac Society)
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41249034
Summary: This study demonstrated the comparative diagnostic accuracy of several tools for heart failure with preserved ejection fraction (H. F. pEF) across community and clinical cohorts. Researchers found that the Heart Failure Association-P. E. F. F. and H. two F. P. E. F. Scores showed differing diagnostic performance when compared against inclusion criteria from sodium-glucose cotransporter-two inhibitors trials and age-adjusted N-terminal pro B-type natriuretic peptide. The data provided clarification on the strengths and limitations of each diagnostic approach, particularly highlighting their utility in older adult populations where H. F. pEF diagnosis is most challenging. These findings contribute to refining the clinical algorithm for accurate identification of H. F. pEF.
Article 4: Therapy gaps for patients with heart failure and reduced kidney function: A prospective cohort study.
Journal: ESC heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41243130
Summary: This prospective cohort study identified significant therapy gaps in the contemporary management of patients with heart failure and reduced kidney function. Researchers evaluated longitudinal treatment patterns over two years in 1401 heart failure patients, finding that the use and dose intensity of guideline-directed heart failure therapies varied considerably across the spectrum of kidney function and left ventricular ejection fraction. The data demonstrated that a substantial proportion of patients with kidney dysfunction did not receive optimal heart failure pharmacotherapies or were underdosed. These findings highlight unmet therapeutic needs in this vulnerable patient population, indicating a discrepancy between emerging evidence and current clinical practice.
Article 5: Impact of Left Atrial v-Wave Following Mitral Edge-to-Edge Repair on Survival: The MITRA-PRO Registry.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41246815
Summary: This study found that left atrial v-wave assessment following transcatheter edge-to-edge repair for mitral regurgitation had a significant impact on long-term patient survival. Data from the M. I. T. R. A.-P. R. O. registry, involving 1487 patients, showed that after three years, survival was significantly reduced in patients with an elevated postprocedural v-wave. These findings establish the postprocedural v-wave as a crucial prognostic indicator for long-term outcomes following mitral valve intervention. The study demonstrates the importance of assessing left atrial pressure dynamics after T. E. E. R. for risk stratification and patient management.
Transcript
Today’s date is November 19, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Isolated non-specific electrocardiographic ST-T abnormalities and risk of incident heart failure and its subtypes. Isolated non-specific S. T. T. abnormalities on electrocardiograms were found to be associated with an increased risk of incident coronary heart disease and stroke in participants free of these conditions at baseline. This study also found that these abnormalities were linked to an increased risk of incident heart failure and its subtypes. Data showed that these specific electrocardiographic patterns, defined by Minnesota E. C. G. classification, independently predicted future development of heart failure, including both heart failure with preserved ejection fraction and heart failure with reduced ejection fraction. These findings establish a prognostic role for isolated non-specific S. T. T. abnormalities in identifying individuals at risk for future cardiovascular events and heart failure.
Article number two. Estimating 5-year absolute risk of cardiovascular disease using routinely collected electronic medical records from Australian general practices. This study demonstrated the feasibility and performance of using routinely collected electronic medical records from Australian general practices to estimate the 5-year absolute risk of cardiovascular disease. Researchers found that integrating primary care electronic medical record data, specifically from the New South Wales Health Lumos program, provided a viable approach for cardiovascular risk prediction. The study successfully utilized data from 680 general practices to assess the predictive capability of these records. These findings indicate that Australian healthcare systems can effectively leverage existing electronic medical records for robust cardiovascular disease risk estimation, comparable to methods used in the U. S. A. and U. K.
Article number three. Comparing diagnostic tools for heart failure with preserved ejection fraction across community and clinical cohorts. This study demonstrated the comparative diagnostic accuracy of several tools for heart failure with preserved ejection fraction (H. F. pEF) across community and clinical cohorts. Researchers found that the Heart Failure Association-P. E. F. F. and H. two F. P. E. F. Scores showed differing diagnostic performance when compared against inclusion criteria from sodium-glucose cotransporter-two inhibitors trials and age-adjusted N-terminal pro B-type natriuretic peptide. The data provided clarification on the strengths and limitations of each diagnostic approach, particularly highlighting their utility in older adult populations where H. F. pEF diagnosis is most challenging. These findings contribute to refining the clinical algorithm for accurate identification of H. F. pEF.
Article number four. Therapy gaps for patients with heart failure and reduced kidney function: A prospective cohort study. This prospective cohort study identified significant therapy gaps in the contemporary management of patients with heart failure and reduced kidney function. Researchers evaluated longitudinal treatment patterns over two years in 1401 heart failure patients, finding that the use and dose intensity of guideline-directed heart failure therapies varied considerably across the spectrum of kidney function and left ventricular ejection fraction. The data demonstrated that a substantial proportion of patients with kidney dysfunction did not receive optimal heart failure pharmacotherapies or were underdosed. These findings highlight unmet therapeutic needs in this vulnerable patient population, indicating a discrepancy between emerging evidence and current clinical practice.
Article number five. Impact of Left Atrial v-Wave Following Mitral Edge-to-Edge Repair on Survival: The MITRA-PRO Registry. This study found that left atrial v-wave assessment following transcatheter edge-to-edge repair for mitral regurgitation had a significant impact on long-term patient survival. Data from the M. I. T. R. A.-P. R. O. registry, involving 1487 patients, showed that after three years, survival was significantly reduced in patients with an elevated postprocedural v-wave. These findings establish the postprocedural v-wave as a crucial prognostic indicator for long-term outcomes following mitral valve intervention. The study demonstrates the importance of assessing left atrial pressure dynamics after T. E. E. R. for risk stratification and patient management.
Thank you for listening. Don’t forget to subscribe.
Keywords
heart failure, stroke, v-wave, primary care, electrocardiographic abnormalities, H. two F. P. E. F. Score, Heart Failure Association-P. E. F. F. Score, cardiovascular disease, treatment gaps, dose intensity, S. T. T. abnormalities, transcatheter mitral repair, heart failure with preserved ejection fraction, diagnostic tools, risk prediction, absolute risk, survival, N. T.-proB. N. P., coronary heart disease, mitral edge-to-edge repair, pharmacotherapy, left atrial pressure, kidney dysfunction, electronic medical records.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post ECG Abnormalities Predict Heart Failure Risk 11/19/25 first appeared on Cardiology Today.
Article Links:
Article 1: Isolated non-specific electrocardiographic ST-T abnormalities and risk of incident heart failure and its subtypes. (Heart (British Cardiac Society))
Article 2: Estimating 5-year absolute risk of cardiovascular disease using routinely collected electronic medical records from Australian general practices. (Heart (British Cardiac Society))
Article 3: Comparing diagnostic tools for heart failure with preserved ejection fraction across community and clinical cohorts. (Heart (British Cardiac Society))
Article 4: Therapy gaps for patients with heart failure and reduced kidney function: A prospective cohort study. (ESC heart failure)
Article 5: Impact of Left Atrial v-Wave Following Mitral Edge-to-Edge Repair on Survival: The MITRA-PRO Registry. (Journal of the American Heart Association)
Full episode page: https://podcast.explainheart.com/podcast/ecg-abnormalities-predict-heart-failure-risk-11-19-25/
Featured Articles
Article 1: Isolated non-specific electrocardiographic ST-T abnormalities and risk of incident heart failure and its subtypes.
Journal: Heart (British Cardiac Society)
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41249037
Summary: Isolated non-specific S. T. T. abnormalities on electrocardiograms were found to be associated with an increased risk of incident coronary heart disease and stroke in participants free of these conditions at baseline. This study also found that these abnormalities were linked to an increased risk of incident heart failure and its subtypes. Data showed that these specific electrocardiographic patterns, defined by Minnesota E. C. G. classification, independently predicted future development of heart failure, including both heart failure with preserved ejection fraction and heart failure with reduced ejection fraction. These findings establish a prognostic role for isolated non-specific S. T. T. abnormalities in identifying individuals at risk for future cardiovascular events and heart failure.
Article 2: Estimating 5-year absolute risk of cardiovascular disease using routinely collected electronic medical records from Australian general practices.
Journal: Heart (British Cardiac Society)
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41249035
Summary: This study demonstrated the feasibility and performance of using routinely collected electronic medical records from Australian general practices to estimate the 5-year absolute risk of cardiovascular disease. Researchers found that integrating primary care electronic medical record data, specifically from the New South Wales Health Lumos program, provided a viable approach for cardiovascular risk prediction. The study successfully utilized data from 680 general practices to assess the predictive capability of these records. These findings indicate that Australian healthcare systems can effectively leverage existing electronic medical records for robust cardiovascular disease risk estimation, comparable to methods used in the U. S. A. and U. K.
Article 3: Comparing diagnostic tools for heart failure with preserved ejection fraction across community and clinical cohorts.
Journal: Heart (British Cardiac Society)
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41249034
Summary: This study demonstrated the comparative diagnostic accuracy of several tools for heart failure with preserved ejection fraction (H. F. pEF) across community and clinical cohorts. Researchers found that the Heart Failure Association-P. E. F. F. and H. two F. P. E. F. Scores showed differing diagnostic performance when compared against inclusion criteria from sodium-glucose cotransporter-two inhibitors trials and age-adjusted N-terminal pro B-type natriuretic peptide. The data provided clarification on the strengths and limitations of each diagnostic approach, particularly highlighting their utility in older adult populations where H. F. pEF diagnosis is most challenging. These findings contribute to refining the clinical algorithm for accurate identification of H. F. pEF.
Article 4: Therapy gaps for patients with heart failure and reduced kidney function: A prospective cohort study.
Journal: ESC heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41243130
Summary: This prospective cohort study identified significant therapy gaps in the contemporary management of patients with heart failure and reduced kidney function. Researchers evaluated longitudinal treatment patterns over two years in 1401 heart failure patients, finding that the use and dose intensity of guideline-directed heart failure therapies varied considerably across the spectrum of kidney function and left ventricular ejection fraction. The data demonstrated that a substantial proportion of patients with kidney dysfunction did not receive optimal heart failure pharmacotherapies or were underdosed. These findings highlight unmet therapeutic needs in this vulnerable patient population, indicating a discrepancy between emerging evidence and current clinical practice.
Article 5: Impact of Left Atrial v-Wave Following Mitral Edge-to-Edge Repair on Survival: The MITRA-PRO Registry.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41246815
Summary: This study found that left atrial v-wave assessment following transcatheter edge-to-edge repair for mitral regurgitation had a significant impact on long-term patient survival. Data from the M. I. T. R. A.-P. R. O. registry, involving 1487 patients, showed that after three years, survival was significantly reduced in patients with an elevated postprocedural v-wave. These findings establish the postprocedural v-wave as a crucial prognostic indicator for long-term outcomes following mitral valve intervention. The study demonstrates the importance of assessing left atrial pressure dynamics after T. E. E. R. for risk stratification and patient management.
Transcript
Today’s date is November 19, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Isolated non-specific electrocardiographic ST-T abnormalities and risk of incident heart failure and its subtypes. Isolated non-specific S. T. T. abnormalities on electrocardiograms were found to be associated with an increased risk of incident coronary heart disease and stroke in participants free of these conditions at baseline. This study also found that these abnormalities were linked to an increased risk of incident heart failure and its subtypes. Data showed that these specific electrocardiographic patterns, defined by Minnesota E. C. G. classification, independently predicted future development of heart failure, including both heart failure with preserved ejection fraction and heart failure with reduced ejection fraction. These findings establish a prognostic role for isolated non-specific S. T. T. abnormalities in identifying individuals at risk for future cardiovascular events and heart failure.
Article number two. Estimating 5-year absolute risk of cardiovascular disease using routinely collected electronic medical records from Australian general practices. This study demonstrated the feasibility and performance of using routinely collected electronic medical records from Australian general practices to estimate the 5-year absolute risk of cardiovascular disease. Researchers found that integrating primary care electronic medical record data, specifically from the New South Wales Health Lumos program, provided a viable approach for cardiovascular risk prediction. The study successfully utilized data from 680 general practices to assess the predictive capability of these records. These findings indicate that Australian healthcare systems can effectively leverage existing electronic medical records for robust cardiovascular disease risk estimation, comparable to methods used in the U. S. A. and U. K.
Article number three. Comparing diagnostic tools for heart failure with preserved ejection fraction across community and clinical cohorts. This study demonstrated the comparative diagnostic accuracy of several tools for heart failure with preserved ejection fraction (H. F. pEF) across community and clinical cohorts. Researchers found that the Heart Failure Association-P. E. F. F. and H. two F. P. E. F. Scores showed differing diagnostic performance when compared against inclusion criteria from sodium-glucose cotransporter-two inhibitors trials and age-adjusted N-terminal pro B-type natriuretic peptide. The data provided clarification on the strengths and limitations of each diagnostic approach, particularly highlighting their utility in older adult populations where H. F. pEF diagnosis is most challenging. These findings contribute to refining the clinical algorithm for accurate identification of H. F. pEF.
Article number four. Therapy gaps for patients with heart failure and reduced kidney function: A prospective cohort study. This prospective cohort study identified significant therapy gaps in the contemporary management of patients with heart failure and reduced kidney function. Researchers evaluated longitudinal treatment patterns over two years in 1401 heart failure patients, finding that the use and dose intensity of guideline-directed heart failure therapies varied considerably across the spectrum of kidney function and left ventricular ejection fraction. The data demonstrated that a substantial proportion of patients with kidney dysfunction did not receive optimal heart failure pharmacotherapies or were underdosed. These findings highlight unmet therapeutic needs in this vulnerable patient population, indicating a discrepancy between emerging evidence and current clinical practice.
Article number five. Impact of Left Atrial v-Wave Following Mitral Edge-to-Edge Repair on Survival: The MITRA-PRO Registry. This study found that left atrial v-wave assessment following transcatheter edge-to-edge repair for mitral regurgitation had a significant impact on long-term patient survival. Data from the M. I. T. R. A.-P. R. O. registry, involving 1487 patients, showed that after three years, survival was significantly reduced in patients with an elevated postprocedural v-wave. These findings establish the postprocedural v-wave as a crucial prognostic indicator for long-term outcomes following mitral valve intervention. The study demonstrates the importance of assessing left atrial pressure dynamics after T. E. E. R. for risk stratification and patient management.
Thank you for listening. Don’t forget to subscribe.
Keywords
heart failure, stroke, v-wave, primary care, electrocardiographic abnormalities, H. two F. P. E. F. Score, Heart Failure Association-P. E. F. F. Score, cardiovascular disease, treatment gaps, dose intensity, S. T. T. abnormalities, transcatheter mitral repair, heart failure with preserved ejection fraction, diagnostic tools, risk prediction, absolute risk, survival, N. T.-proB. N. P., coronary heart disease, mitral edge-to-edge repair, pharmacotherapy, left atrial pressure, kidney dysfunction, electronic medical records.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post ECG Abnormalities Predict Heart Failure Risk 11/19/25 first appeared on Cardiology Today.
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