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Listen "PA-Led Heart Transplant Recovery: Safe, Effective 11/15/25"
Episode Synopsis
Welcome to Cardiology Today – Recorded November 15, 2025. This episode summarizes 5 key cardiology studies on topics like Transcatheter aortic valve replacement and Heart failure. Key takeaway: PA-Led Heart Transplant Recovery: Safe, Effective.
Article Links:
Article 1: Implementation of a Physician Assistant-Led Recovery Model for Heart Transplantation: Clinical Outcomes and Programmatic Benefits at a High-Volume Center. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons)
Article 2: Effect of low-dose colchicine on pericoronary inflammation and coronary plaque composition in chronic coronary disease: a subanalysis of the LoDoCo2 trial. (Heart (British Cardiac Society))
Article 3: Incidence, predictors and clinical impact of upper gastrointestinal bleeding after transcatheter aortic valve replacement. (Heart (British Cardiac Society))
Article 4: Incidence, predictors and outcomes of tricuspid regurgitation progression after left-sided valvular intervention. (Heart (British Cardiac Society))
Article 5: Determinants of diuresis/natriuresis following ambulatory intravenous loop diuretics for worsening heart failure. (ESC heart failure)
Full episode page: https://podcast.explainheart.com/podcast/pa-led-heart-transplant-recovery-safe-effective-11-15-25/
Featured Articles
Article 1: Implementation of a Physician Assistant-Led Recovery Model for Heart Transplantation: Clinical Outcomes and Programmatic Benefits at a High-Volume Center.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41238023
Summary: This observational cohort study assessed the clinical outcomes and programmatic benefits of a physician assistant-led allograft recovery model for adult heart transplantation. Researchers compared 130 transplantations using physician assistant teams with 367 using non-physician assistant teams at a high-volume center between 2020 and 2024. The implementation of this physician assistant-led model for donor organ recovery demonstrated comparable clinical outcomes for heart transplantation recipients. This model offers significant programmatic advantages, potentially enhancing efficiency and resource utilization within heart transplantation programs.
Article 2: Effect of low-dose colchicine on pericoronary inflammation and coronary plaque composition in chronic coronary disease: a subanalysis of the LoDoCo2 trial.
Journal: Heart (British Cardiac Society)
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40393691
Summary: This subanalysis of the Low-Dose Colchicine 2 Trial aimed to investigate the effect of low-dose colchicine on pericoronary inflammation and coronary plaque composition. Researchers performed cross-sectional computed tomography angiography studies in 151 participants with chronic coronary disease. The primary objective was to understand the underlying mechanisms by which low-dose colchicine, administered at 0.5 mg once daily, reduces the risk of major cardiovascular events. This study established a methodology to assess how colchicine may exert its beneficial anti-inflammatory actions on coronary arteries.
Article 3: Incidence, predictors and clinical impact of upper gastrointestinal bleeding after transcatheter aortic valve replacement.
Journal: Heart (British Cardiac Society)
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40348411
Summary: This prospective registry study investigated the incidence, predictors, and clinical impact of late upper gastrointestinal bleeding following transcatheter aortic valve replacement. Researchers analyzed 3144 patients, stratifying them based on the occurrence of upper gastrointestinal bleeding within one year of hospital discharge. The study characterized the frequency of this complication in transcatheter aortic valve replacement patients and identified specific factors that predict its occurrence. Understanding these predictors is crucial for implementing targeted preventative strategies and improving patient safety after this cardiac procedure.
Article 4: Incidence, predictors and outcomes of tricuspid regurgitation progression after left-sided valvular intervention.
Journal: Heart (British Cardiac Society)
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40312105
Summary: This study determined the incidence, predictors, and clinical outcomes of tricuspid regurgitation progression following left-sided valvular intervention. Researchers analyzed one thousand six hundred forty-four patients who underwent surgical or transcatheter treatment for aortic or mitral valve disease, excluding those with severe tricuspid regurgitation at baseline. The study defined tricuspid regurgitation progression as an increase to at least moderate or severe grade, identifying key factors influencing this critical clinical concern. This research provides essential information for risk stratification and monitoring strategies to prevent worsening tricuspid regurgitation in this patient population.
Article 5: Determinants of diuresis/natriuresis following ambulatory intravenous loop diuretics for worsening heart failure.
Journal: ESC heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41229332
Summary: This study aimed to identify factors determining diuresis and natriuresis after ambulatory intravenous loop diuretic administration for worsening heart failure. Researchers analyzed patients receiving four-hour intravenous diuretic sessions, which included an initial bolus followed by a tailored continuous infusion protocol. The research focused on advanced heart failure patients with frequent hospital admissions, representing a challenging clinical population. Understanding these determinants is crucial for optimizing diuretic response in an outpatient setting, potentially reducing hospitalization rates and improving patient care.
Transcript
Today’s date is November 15, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Implementation of a Physician Assistant-Led Recovery Model for Heart Transplantation: Clinical Outcomes and Programmatic Benefits at a High-Volume Center. This observational cohort study assessed the clinical outcomes and programmatic benefits of a physician assistant-led allograft recovery model for adult heart transplantation. Researchers compared 130 transplantations using physician assistant teams with 367 using non-physician assistant teams at a high-volume center between 2020 and 2024. The implementation of this physician assistant-led model for donor organ recovery demonstrated comparable clinical outcomes for heart transplantation recipients. This model offers significant programmatic advantages, potentially enhancing efficiency and resource utilization within heart transplantation programs.
Article number two. Effect of low-dose colchicine on pericoronary inflammation and coronary plaque composition in chronic coronary disease: a subanalysis of the LoDoCo2 trial. This subanalysis of the Low-Dose Colchicine 2 Trial aimed to investigate the effect of low-dose colchicine on pericoronary inflammation and coronary plaque composition. Researchers performed cross-sectional computed tomography angiography studies in 151 participants with chronic coronary disease. The primary objective was to understand the underlying mechanisms by which low-dose colchicine, administered at 0.5 mg once daily, reduces the risk of major cardiovascular events. This study established a methodology to assess how colchicine may exert its beneficial anti-inflammatory actions on coronary arteries.
Article number three. Incidence, predictors and clinical impact of upper gastrointestinal bleeding after transcatheter aortic valve replacement. This prospective registry study investigated the incidence, predictors, and clinical impact of late upper gastrointestinal bleeding following transcatheter aortic valve replacement. Researchers analyzed 3144 patients, stratifying them based on the occurrence of upper gastrointestinal bleeding within one year of hospital discharge. The study characterized the frequency of this complication in transcatheter aortic valve replacement patients and identified specific factors that predict its occurrence. Understanding these predictors is crucial for implementing targeted preventative strategies and improving patient safety after this cardiac procedure.
Article number four. Incidence, predictors and outcomes of tricuspid regurgitation progression after left-sided valvular intervention. This study determined the incidence, predictors, and clinical outcomes of tricuspid regurgitation progression following left-sided valvular intervention. Researchers analyzed one thousand six hundred forty-four patients who underwent surgical or transcatheter treatment for aortic or mitral valve disease, excluding those with severe tricuspid regurgitation at baseline. The study defined tricuspid regurgitation progression as an increase to at least moderate or severe grade, identifying key factors influencing this critical clinical concern. This research provides essential information for risk stratification and monitoring strategies to prevent worsening tricuspid regurgitation in this patient population.
Article number five. Determinants of diuresis/natriuresis following ambulatory intravenous loop diuretics for worsening heart failure. This study aimed to identify factors determining diuresis and natriuresis after ambulatory intravenous loop diuretic administration for worsening heart failure. Researchers analyzed patients receiving four-hour intravenous diuretic sessions, which included an initial bolus followed by a tailored continuous infusion protocol. The research focused on advanced heart failure patients with frequent hospital admissions, representing a challenging clinical population. Understanding these determinants is crucial for optimizing diuretic response in an outpatient setting, potentially reducing hospitalization rates and improving patient care.
Thank you for listening. Don’t forget to subscribe.
Keywords
Transcatheter aortic valve replacement, Heart failure, Low-dose colchicine, allograft recovery, pericoronary inflammation, computed tomography angiography, ambulatory care, donor organ procurement, transcatheter treatment, chronic coronary disease, aortic stenosis, loop diuretics, left-sided valvular heart disease, natriuresis, diuresis, aortic valve disease, intravenous diuretics, physician assistant, coronary plaque, Tricuspid regurgitation, clinical outcomes, upper gastrointestinal bleeding, antiplatelet therapy, Heart transplantation, mitral valve disease.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post PA-Led Heart Transplant Recovery: Safe, Effective 11/15/25 first appeared on Cardiology Today.
Article Links:
Article 1: Implementation of a Physician Assistant-Led Recovery Model for Heart Transplantation: Clinical Outcomes and Programmatic Benefits at a High-Volume Center. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons)
Article 2: Effect of low-dose colchicine on pericoronary inflammation and coronary plaque composition in chronic coronary disease: a subanalysis of the LoDoCo2 trial. (Heart (British Cardiac Society))
Article 3: Incidence, predictors and clinical impact of upper gastrointestinal bleeding after transcatheter aortic valve replacement. (Heart (British Cardiac Society))
Article 4: Incidence, predictors and outcomes of tricuspid regurgitation progression after left-sided valvular intervention. (Heart (British Cardiac Society))
Article 5: Determinants of diuresis/natriuresis following ambulatory intravenous loop diuretics for worsening heart failure. (ESC heart failure)
Full episode page: https://podcast.explainheart.com/podcast/pa-led-heart-transplant-recovery-safe-effective-11-15-25/
Featured Articles
Article 1: Implementation of a Physician Assistant-Led Recovery Model for Heart Transplantation: Clinical Outcomes and Programmatic Benefits at a High-Volume Center.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41238023
Summary: This observational cohort study assessed the clinical outcomes and programmatic benefits of a physician assistant-led allograft recovery model for adult heart transplantation. Researchers compared 130 transplantations using physician assistant teams with 367 using non-physician assistant teams at a high-volume center between 2020 and 2024. The implementation of this physician assistant-led model for donor organ recovery demonstrated comparable clinical outcomes for heart transplantation recipients. This model offers significant programmatic advantages, potentially enhancing efficiency and resource utilization within heart transplantation programs.
Article 2: Effect of low-dose colchicine on pericoronary inflammation and coronary plaque composition in chronic coronary disease: a subanalysis of the LoDoCo2 trial.
Journal: Heart (British Cardiac Society)
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40393691
Summary: This subanalysis of the Low-Dose Colchicine 2 Trial aimed to investigate the effect of low-dose colchicine on pericoronary inflammation and coronary plaque composition. Researchers performed cross-sectional computed tomography angiography studies in 151 participants with chronic coronary disease. The primary objective was to understand the underlying mechanisms by which low-dose colchicine, administered at 0.5 mg once daily, reduces the risk of major cardiovascular events. This study established a methodology to assess how colchicine may exert its beneficial anti-inflammatory actions on coronary arteries.
Article 3: Incidence, predictors and clinical impact of upper gastrointestinal bleeding after transcatheter aortic valve replacement.
Journal: Heart (British Cardiac Society)
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40348411
Summary: This prospective registry study investigated the incidence, predictors, and clinical impact of late upper gastrointestinal bleeding following transcatheter aortic valve replacement. Researchers analyzed 3144 patients, stratifying them based on the occurrence of upper gastrointestinal bleeding within one year of hospital discharge. The study characterized the frequency of this complication in transcatheter aortic valve replacement patients and identified specific factors that predict its occurrence. Understanding these predictors is crucial for implementing targeted preventative strategies and improving patient safety after this cardiac procedure.
Article 4: Incidence, predictors and outcomes of tricuspid regurgitation progression after left-sided valvular intervention.
Journal: Heart (British Cardiac Society)
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40312105
Summary: This study determined the incidence, predictors, and clinical outcomes of tricuspid regurgitation progression following left-sided valvular intervention. Researchers analyzed one thousand six hundred forty-four patients who underwent surgical or transcatheter treatment for aortic or mitral valve disease, excluding those with severe tricuspid regurgitation at baseline. The study defined tricuspid regurgitation progression as an increase to at least moderate or severe grade, identifying key factors influencing this critical clinical concern. This research provides essential information for risk stratification and monitoring strategies to prevent worsening tricuspid regurgitation in this patient population.
Article 5: Determinants of diuresis/natriuresis following ambulatory intravenous loop diuretics for worsening heart failure.
Journal: ESC heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41229332
Summary: This study aimed to identify factors determining diuresis and natriuresis after ambulatory intravenous loop diuretic administration for worsening heart failure. Researchers analyzed patients receiving four-hour intravenous diuretic sessions, which included an initial bolus followed by a tailored continuous infusion protocol. The research focused on advanced heart failure patients with frequent hospital admissions, representing a challenging clinical population. Understanding these determinants is crucial for optimizing diuretic response in an outpatient setting, potentially reducing hospitalization rates and improving patient care.
Transcript
Today’s date is November 15, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Implementation of a Physician Assistant-Led Recovery Model for Heart Transplantation: Clinical Outcomes and Programmatic Benefits at a High-Volume Center. This observational cohort study assessed the clinical outcomes and programmatic benefits of a physician assistant-led allograft recovery model for adult heart transplantation. Researchers compared 130 transplantations using physician assistant teams with 367 using non-physician assistant teams at a high-volume center between 2020 and 2024. The implementation of this physician assistant-led model for donor organ recovery demonstrated comparable clinical outcomes for heart transplantation recipients. This model offers significant programmatic advantages, potentially enhancing efficiency and resource utilization within heart transplantation programs.
Article number two. Effect of low-dose colchicine on pericoronary inflammation and coronary plaque composition in chronic coronary disease: a subanalysis of the LoDoCo2 trial. This subanalysis of the Low-Dose Colchicine 2 Trial aimed to investigate the effect of low-dose colchicine on pericoronary inflammation and coronary plaque composition. Researchers performed cross-sectional computed tomography angiography studies in 151 participants with chronic coronary disease. The primary objective was to understand the underlying mechanisms by which low-dose colchicine, administered at 0.5 mg once daily, reduces the risk of major cardiovascular events. This study established a methodology to assess how colchicine may exert its beneficial anti-inflammatory actions on coronary arteries.
Article number three. Incidence, predictors and clinical impact of upper gastrointestinal bleeding after transcatheter aortic valve replacement. This prospective registry study investigated the incidence, predictors, and clinical impact of late upper gastrointestinal bleeding following transcatheter aortic valve replacement. Researchers analyzed 3144 patients, stratifying them based on the occurrence of upper gastrointestinal bleeding within one year of hospital discharge. The study characterized the frequency of this complication in transcatheter aortic valve replacement patients and identified specific factors that predict its occurrence. Understanding these predictors is crucial for implementing targeted preventative strategies and improving patient safety after this cardiac procedure.
Article number four. Incidence, predictors and outcomes of tricuspid regurgitation progression after left-sided valvular intervention. This study determined the incidence, predictors, and clinical outcomes of tricuspid regurgitation progression following left-sided valvular intervention. Researchers analyzed one thousand six hundred forty-four patients who underwent surgical or transcatheter treatment for aortic or mitral valve disease, excluding those with severe tricuspid regurgitation at baseline. The study defined tricuspid regurgitation progression as an increase to at least moderate or severe grade, identifying key factors influencing this critical clinical concern. This research provides essential information for risk stratification and monitoring strategies to prevent worsening tricuspid regurgitation in this patient population.
Article number five. Determinants of diuresis/natriuresis following ambulatory intravenous loop diuretics for worsening heart failure. This study aimed to identify factors determining diuresis and natriuresis after ambulatory intravenous loop diuretic administration for worsening heart failure. Researchers analyzed patients receiving four-hour intravenous diuretic sessions, which included an initial bolus followed by a tailored continuous infusion protocol. The research focused on advanced heart failure patients with frequent hospital admissions, representing a challenging clinical population. Understanding these determinants is crucial for optimizing diuretic response in an outpatient setting, potentially reducing hospitalization rates and improving patient care.
Thank you for listening. Don’t forget to subscribe.
Keywords
Transcatheter aortic valve replacement, Heart failure, Low-dose colchicine, allograft recovery, pericoronary inflammation, computed tomography angiography, ambulatory care, donor organ procurement, transcatheter treatment, chronic coronary disease, aortic stenosis, loop diuretics, left-sided valvular heart disease, natriuresis, diuresis, aortic valve disease, intravenous diuretics, physician assistant, coronary plaque, Tricuspid regurgitation, clinical outcomes, upper gastrointestinal bleeding, antiplatelet therapy, Heart transplantation, mitral valve disease.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post PA-Led Heart Transplant Recovery: Safe, Effective 11/15/25 first appeared on Cardiology Today.
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