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Listen "Simplified DCD Heart Tx: 100 percent Graft Function. 11/16/25"
Episode Synopsis
Welcome to Cardiology Today – Recorded November 16, 2025. This episode summarizes 5 key cardiology studies on topics like myocardial performance score and right ventricular failure. Key takeaway: Simplified DCD Heart Tx: 100 percent Graft Function..
Article Links:
Article 1: DCD Heart Transplantation Using Simplified Direct Procurement: Expanding Access. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
Article 2: Defining the relationships among four tests for assessing antibody-mediated rejection in heart transplants in a prospective, observational study. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
Article 3: Low Rates of Inotropic Support and Durable Left Ventricular Assist Device Placement among Status 2 Heart Transplant Candidates with Temporary Mechanical Circulatory Support. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
Article 4: Advanced Hemodynamics for Right Ventricular Failure: Evaluating the use of the Myocardial Performance Score. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
Article 5: Ex-vivo Heart Perfusion Attenuates Early Post-Transplant Risk After Prolonged Agonal Period in DCD Heart Transplantation. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
Full episode page: https://podcast.explainheart.com/podcast/simplified-dcd-heart-tx-100-percent-graft-function-11-16-25/
Featured Articles
Article 1: DCD Heart Transplantation Using Simplified Direct Procurement: Expanding Access.
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41241036
Summary: This study successfully performed five heart transplantations using a simplified direct procurement technique from donation after circulatory death donors. All five recipients demonstrated normal cardiac graft function after the procedure. No evidence of rejection was observed during their short-term follow-up period. The approach, which employed cold blood perfusion and preservation solution, proved to be both feasible and logistically efficient.
Article 2: Defining the relationships among four tests for assessing antibody-mediated rejection in heart transplants in a prospective, observational study.
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41241034
Summary: The Trifecta-Heart study compared four tests used to assess antibody-mediated rejection in heart transplant patients: standard endomyocardial biopsy histology, endomyocardial biopsy molecular analysis using the Molecular Microscope Diagnostic System, donor-derived cell-free D. N. A., and donor-specific antibody measurements. Specific numerical results defining the relationships among these tests were not provided in the abstract. The abstract focused on the comparison of these assessment methods.
Article 3: Low Rates of Inotropic Support and Durable Left Ventricular Assist Device Placement among Status 2 Heart Transplant Candidates with Temporary Mechanical Circulatory Support.
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41241033
Summary: Following the 2018 heart allocation policy change, status two listings for heart transplant candidates with temporary mechanical circulatory support were observed to increase, while listings for durable left ventricular assist devices decreased. The study identified adult heart transplant candidates from the Scientific Registry of Transplant Recipients. Specific numerical data detailing the low rates of inotropic support and durable left ventricular assist device placement were not included in this abstract.
Article 4: Advanced Hemodynamics for Right Ventricular Failure: Evaluating the use of the Myocardial Performance Score.
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41241032
Summary: This study performed 800 pressure-volume loop in silico simulations to evaluate right ventricular myocardial performance. The right ventricular myocardial performance score was precisely calculated using the formula (3 multiplied by pulmonary artery pulsatility index multiplied by right ventricular cardiac power output) divided by 2. A validation cohort comprising 223 patients was included for further assessment. Specific findings regarding the utility of the right ventricular myocardial performance score as a marker for right ventricular function and prognosis were not detailed in this abstract.
Article 5: Ex-vivo Heart Perfusion Attenuates Early Post-Transplant Risk After Prolonged Agonal Period in DCD Heart Transplantation.
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41241031
Summary: This study investigated the impact of ex-vivo heart perfusion on outcomes in donation after circulatory death heart transplantation following a prolonged agonal period. Adult isolated heart transplants reported to the United Network for Organ Sharing thoracic registry between January 2019 and April 2025 were reviewed. Ex-vivo heart perfusion was defined as the primary exposure for analysis. Concrete findings and specific numerical results demonstrating the attenuation of early post-transplant risk were not provided in the abstract.
Transcript
Today’s date is November 16, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. DCD Heart Transplantation Using Simplified Direct Procurement: Expanding Access. This study successfully performed five heart transplantations using a simplified direct procurement technique from donation after circulatory death donors. All five recipients demonstrated normal cardiac graft function after the procedure. No evidence of rejection was observed during their short-term follow-up period. The approach, which employed cold blood perfusion and preservation solution, proved to be both feasible and logistically efficient.
Article number two. Defining the relationships among four tests for assessing antibody-mediated rejection in heart transplants in a prospective, observational study. The Trifecta-Heart study compared four tests used to assess antibody-mediated rejection in heart transplant patients: standard endomyocardial biopsy histology, endomyocardial biopsy molecular analysis using the Molecular Microscope Diagnostic System, donor-derived cell-free D. N. A., and donor-specific antibody measurements. Specific numerical results defining the relationships among these tests were not provided in the abstract. The abstract focused on the comparison of these assessment methods.
Article number three. Low Rates of Inotropic Support and Durable Left Ventricular Assist Device Placement among Status 2 Heart Transplant Candidates with Temporary Mechanical Circulatory Support. Following the 2018 heart allocation policy change, status two listings for heart transplant candidates with temporary mechanical circulatory support were observed to increase, while listings for durable left ventricular assist devices decreased. The study identified adult heart transplant candidates from the Scientific Registry of Transplant Recipients. Specific numerical data detailing the low rates of inotropic support and durable left ventricular assist device placement were not included in this abstract.
Article number four. Advanced Hemodynamics for Right Ventricular Failure: Evaluating the use of the Myocardial Performance Score. This study performed 800 pressure-volume loop in silico simulations to evaluate right ventricular myocardial performance. The right ventricular myocardial performance score was precisely calculated using the formula (3 multiplied by pulmonary artery pulsatility index multiplied by right ventricular cardiac power output) divided by 2. A validation cohort comprising 223 patients was included for further assessment. Specific findings regarding the utility of the right ventricular myocardial performance score as a marker for right ventricular function and prognosis were not detailed in this abstract.
Article number five. Ex-vivo Heart Perfusion Attenuates Early Post-Transplant Risk After Prolonged Agonal Period in DCD Heart Transplantation. This study investigated the impact of ex-vivo heart perfusion on outcomes in donation after circulatory death heart transplantation following a prolonged agonal period. Adult isolated heart transplants reported to the United Network for Organ Sharing thoracic registry between January 2019 and April 2025 were reviewed. Ex-vivo heart perfusion was defined as the primary exposure for analysis. Concrete findings and specific numerical results demonstrating the attenuation of early post-transplant risk were not provided in the abstract.
Thank you for listening. Don’t forget to subscribe.
Keywords
myocardial performance score, right ventricular failure, hemodynamics, cold perfusion, antibody-mediated rejection, heart transplant, donor-derived cell-free D. N. A., heart transplant candidates, pressure-volume loop, left ventricular assist device, donor-specific antibody, ex-vivo heart perfusion, donation after circulatory death, direct procurement, graft function, Scientific Registry of Transplant Recipients, heart allocation policy, endomyocardial biopsy, pulmonary artery pulsatility index, heart transplantation, warm ischemic injury, temporary mechanical circulatory support, agonal period.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post Simplified DCD Heart Tx: 100 percent Graft Function. 11/16/25 first appeared on Cardiology Today.
Article Links:
Article 1: DCD Heart Transplantation Using Simplified Direct Procurement: Expanding Access. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
Article 2: Defining the relationships among four tests for assessing antibody-mediated rejection in heart transplants in a prospective, observational study. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
Article 3: Low Rates of Inotropic Support and Durable Left Ventricular Assist Device Placement among Status 2 Heart Transplant Candidates with Temporary Mechanical Circulatory Support. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
Article 4: Advanced Hemodynamics for Right Ventricular Failure: Evaluating the use of the Myocardial Performance Score. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
Article 5: Ex-vivo Heart Perfusion Attenuates Early Post-Transplant Risk After Prolonged Agonal Period in DCD Heart Transplantation. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
Full episode page: https://podcast.explainheart.com/podcast/simplified-dcd-heart-tx-100-percent-graft-function-11-16-25/
Featured Articles
Article 1: DCD Heart Transplantation Using Simplified Direct Procurement: Expanding Access.
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41241036
Summary: This study successfully performed five heart transplantations using a simplified direct procurement technique from donation after circulatory death donors. All five recipients demonstrated normal cardiac graft function after the procedure. No evidence of rejection was observed during their short-term follow-up period. The approach, which employed cold blood perfusion and preservation solution, proved to be both feasible and logistically efficient.
Article 2: Defining the relationships among four tests for assessing antibody-mediated rejection in heart transplants in a prospective, observational study.
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41241034
Summary: The Trifecta-Heart study compared four tests used to assess antibody-mediated rejection in heart transplant patients: standard endomyocardial biopsy histology, endomyocardial biopsy molecular analysis using the Molecular Microscope Diagnostic System, donor-derived cell-free D. N. A., and donor-specific antibody measurements. Specific numerical results defining the relationships among these tests were not provided in the abstract. The abstract focused on the comparison of these assessment methods.
Article 3: Low Rates of Inotropic Support and Durable Left Ventricular Assist Device Placement among Status 2 Heart Transplant Candidates with Temporary Mechanical Circulatory Support.
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41241033
Summary: Following the 2018 heart allocation policy change, status two listings for heart transplant candidates with temporary mechanical circulatory support were observed to increase, while listings for durable left ventricular assist devices decreased. The study identified adult heart transplant candidates from the Scientific Registry of Transplant Recipients. Specific numerical data detailing the low rates of inotropic support and durable left ventricular assist device placement were not included in this abstract.
Article 4: Advanced Hemodynamics for Right Ventricular Failure: Evaluating the use of the Myocardial Performance Score.
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41241032
Summary: This study performed 800 pressure-volume loop in silico simulations to evaluate right ventricular myocardial performance. The right ventricular myocardial performance score was precisely calculated using the formula (3 multiplied by pulmonary artery pulsatility index multiplied by right ventricular cardiac power output) divided by 2. A validation cohort comprising 223 patients was included for further assessment. Specific findings regarding the utility of the right ventricular myocardial performance score as a marker for right ventricular function and prognosis were not detailed in this abstract.
Article 5: Ex-vivo Heart Perfusion Attenuates Early Post-Transplant Risk After Prolonged Agonal Period in DCD Heart Transplantation.
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41241031
Summary: This study investigated the impact of ex-vivo heart perfusion on outcomes in donation after circulatory death heart transplantation following a prolonged agonal period. Adult isolated heart transplants reported to the United Network for Organ Sharing thoracic registry between January 2019 and April 2025 were reviewed. Ex-vivo heart perfusion was defined as the primary exposure for analysis. Concrete findings and specific numerical results demonstrating the attenuation of early post-transplant risk were not provided in the abstract.
Transcript
Today’s date is November 16, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. DCD Heart Transplantation Using Simplified Direct Procurement: Expanding Access. This study successfully performed five heart transplantations using a simplified direct procurement technique from donation after circulatory death donors. All five recipients demonstrated normal cardiac graft function after the procedure. No evidence of rejection was observed during their short-term follow-up period. The approach, which employed cold blood perfusion and preservation solution, proved to be both feasible and logistically efficient.
Article number two. Defining the relationships among four tests for assessing antibody-mediated rejection in heart transplants in a prospective, observational study. The Trifecta-Heart study compared four tests used to assess antibody-mediated rejection in heart transplant patients: standard endomyocardial biopsy histology, endomyocardial biopsy molecular analysis using the Molecular Microscope Diagnostic System, donor-derived cell-free D. N. A., and donor-specific antibody measurements. Specific numerical results defining the relationships among these tests were not provided in the abstract. The abstract focused on the comparison of these assessment methods.
Article number three. Low Rates of Inotropic Support and Durable Left Ventricular Assist Device Placement among Status 2 Heart Transplant Candidates with Temporary Mechanical Circulatory Support. Following the 2018 heart allocation policy change, status two listings for heart transplant candidates with temporary mechanical circulatory support were observed to increase, while listings for durable left ventricular assist devices decreased. The study identified adult heart transplant candidates from the Scientific Registry of Transplant Recipients. Specific numerical data detailing the low rates of inotropic support and durable left ventricular assist device placement were not included in this abstract.
Article number four. Advanced Hemodynamics for Right Ventricular Failure: Evaluating the use of the Myocardial Performance Score. This study performed 800 pressure-volume loop in silico simulations to evaluate right ventricular myocardial performance. The right ventricular myocardial performance score was precisely calculated using the formula (3 multiplied by pulmonary artery pulsatility index multiplied by right ventricular cardiac power output) divided by 2. A validation cohort comprising 223 patients was included for further assessment. Specific findings regarding the utility of the right ventricular myocardial performance score as a marker for right ventricular function and prognosis were not detailed in this abstract.
Article number five. Ex-vivo Heart Perfusion Attenuates Early Post-Transplant Risk After Prolonged Agonal Period in DCD Heart Transplantation. This study investigated the impact of ex-vivo heart perfusion on outcomes in donation after circulatory death heart transplantation following a prolonged agonal period. Adult isolated heart transplants reported to the United Network for Organ Sharing thoracic registry between January 2019 and April 2025 were reviewed. Ex-vivo heart perfusion was defined as the primary exposure for analysis. Concrete findings and specific numerical results demonstrating the attenuation of early post-transplant risk were not provided in the abstract.
Thank you for listening. Don’t forget to subscribe.
Keywords
myocardial performance score, right ventricular failure, hemodynamics, cold perfusion, antibody-mediated rejection, heart transplant, donor-derived cell-free D. N. A., heart transplant candidates, pressure-volume loop, left ventricular assist device, donor-specific antibody, ex-vivo heart perfusion, donation after circulatory death, direct procurement, graft function, Scientific Registry of Transplant Recipients, heart allocation policy, endomyocardial biopsy, pulmonary artery pulsatility index, heart transplantation, warm ischemic injury, temporary mechanical circulatory support, agonal period.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post Simplified DCD Heart Tx: 100 percent Graft Function. 11/16/25 first appeared on Cardiology Today.
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