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Listen "Cirrhotic Cardiomyopathy Predicts Post-Transplant Heart Failure 11/18/25"
Episode Synopsis
Welcome to Cardiology Today – Recorded November 18, 2025. This episode summarizes 5 key cardiology studies on topics like precision medicine and temporal trends. Key takeaway: Cirrhotic Cardiomyopathy Predicts Post-Transplant Heart Failure.
Article Links:
Article 1: CD4+ Tregs Regulate Heart Growth and Regeneration Through MRG15/TIP60-Mediated Epigenomic Remodeling in Proliferating Cardiomyocytes. (Circulation)
Article 2: Temporal trends in the use of oral anticoagulants and clinical outcomes in older, elderly, and very elderly patients with atrial fibrillation: a Danish nationwide study. (European heart journal)
Article 3: Automated patch clamp data improve variant classification and penetrance stratification for SCN5A-Brugada syndrome. (European heart journal)
Article 4: Cirrhotic Cardiomyopathy Predicts New-onset Heart Failure Within the First Year After Liver Transplantation. (Transplantation)
Article 5: Role of physician assistants and their impact on cardiology specialty training in the United Kingdom. (Heart (British Cardiac Society))
Full episode page: https://podcast.explainheart.com/podcast/cirrhotic-cardiomyopathy-predicts-post-transplant-heart-failure-11-18-25/
Featured Articles
Article 1: CD4+ Tregs Regulate Heart Growth and Regeneration Through MRG15/TIP60-Mediated Epigenomic Remodeling in Proliferating Cardiomyocytes.
Journal: Circulation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41251000
Summary: The study demonstrated that CD4 positive T regulatory cells regulate heart growth and regeneration. This regulation occurs through M. R. G. fifteen / T. I. P. sixty mediated epigenomic remodeling within proliferating cardiomyocytes. The chromatin regulatory network was found to be crucial in orchestrating the dynamic changes in gene expression for the regenerative response in the neonatal heart. These findings provide a deeper understanding of the mechanisms controlling heart regeneration, which is critical for addressing limited regenerative capacity in the adult mammalian heart.
Article 2: Temporal trends in the use of oral anticoagulants and clinical outcomes in older, elderly, and very elderly patients with atrial fibrillation: a Danish nationwide study.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41251006
Summary: This nationwide Danish study analyzed temporal trends in the use of oral anticoagulants and associated clinical outcomes in older patients with new-onset atrial fibrillation. The study found that anticoagulation therapy patterns in patients with atrial fibrillation have evolved significantly over time, especially following the introduction of direct oral anticoagulants. The analysis investigated how these changes in anticoagulant uptake have impacted clinical outcomes across older adults (65-74 years), elderly (75-84 years), and very elderly (85 years and older) patient groups. This provides critical information on how treatment strategies and patient prognoses for atrial fibrillation have shifted in an aging population.
Article 3: Automated patch clamp data improve variant classification and penetrance stratification for SCN5A-Brugada syndrome.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41251004
Summary: The study demonstrated that automated patch clamp data significantly improves the classification of S. C. N. five A variants and penetrance stratification for Brugada Syndrome. This approach addresses complications in genetic workup arising from S. C. N. five A variants of uncertain significance and incomplete penetrance. The deployment of an S. C. N. five A Brugada Syndrome functional assay at a cohort scale was found to facilitate the implementation of genetic and precision medicine for this inherited arrhythmia disorder. These findings refine the diagnostic and risk stratification process for the approximately 20 percent of Brugada Syndrome patients with rare S. C. N. five A variants.
Article 4: Cirrhotic Cardiomyopathy Predicts New-onset Heart Failure Within the First Year After Liver Transplantation.
Journal: Transplantation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41247366
Summary: This retrospective cohort study found that cirrhotic cardiomyopathy predicts new-onset heart failure within the first year following liver transplantation. The study identified an association between cirrhotic cardiomyopathy, defined using the Cirrhotic Cardiomyopathy Consortium 2020 criteria, and major adverse cardiovascular events after liver transplantation. This established the significant impact of cirrhotic cardiomyopathy on post-transplant cardiac outcomes. These results demonstrate that pre-transplant cardiac assessment for cirrhotic cardiomyopathy is crucial for identifying patients at high risk for developing heart failure after liver transplantation.
Article 5: Role of physician assistants and their impact on cardiology specialty training in the United Kingdom.
Journal: Heart (British Cardiac Society)
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41249040
Summary: This study assessed the role and impact of physician assistants on cardiology specialty training in the United Kingdom by surveying resident doctors. The findings described the current scope of practice for physician assistants within U. K. cardiology, addressing previously undefined roles. The study evaluated the impact of physician assistant expansion on resident doctor training, directly responding to concerns regarding patient safety and training quality. These results provide clarity on the evolving roles of physician assistants in cardiology and their implications for junior cardiologist education and development.
Transcript
Today’s date is November 18, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. CD4+ Tregs Regulate Heart Growth and Regeneration Through MRG15/TIP60-Mediated Epigenomic Remodeling in Proliferating Cardiomyocytes. The study demonstrated that CD4 positive T regulatory cells regulate heart growth and regeneration. This regulation occurs through M. R. G. fifteen / T. I. P. sixty mediated epigenomic remodeling within proliferating cardiomyocytes. The chromatin regulatory network was found to be crucial in orchestrating the dynamic changes in gene expression for the regenerative response in the neonatal heart. These findings provide a deeper understanding of the mechanisms controlling heart regeneration, which is critical for addressing limited regenerative capacity in the adult mammalian heart.
Article number two. Temporal trends in the use of oral anticoagulants and clinical outcomes in older, elderly, and very elderly patients with atrial fibrillation: a Danish nationwide study. This nationwide Danish study analyzed temporal trends in the use of oral anticoagulants and associated clinical outcomes in older patients with new-onset atrial fibrillation. The study found that anticoagulation therapy patterns in patients with atrial fibrillation have evolved significantly over time, especially following the introduction of direct oral anticoagulants. The analysis investigated how these changes in anticoagulant uptake have impacted clinical outcomes across older adults (65-74 years), elderly (75-84 years), and very elderly (85 years and older) patient groups. This provides critical information on how treatment strategies and patient prognoses for atrial fibrillation have shifted in an aging population.
Article number three. Automated patch clamp data improve variant classification and penetrance stratification for SCN5A-Brugada syndrome. The study demonstrated that automated patch clamp data significantly improves the classification of S. C. N. five A variants and penetrance stratification for Brugada Syndrome. This approach addresses complications in genetic workup arising from S. C. N. five A variants of uncertain significance and incomplete penetrance. The deployment of an S. C. N. five A Brugada Syndrome functional assay at a cohort scale was found to facilitate the implementation of genetic and precision medicine for this inherited arrhythmia disorder. These findings refine the diagnostic and risk stratification process for the approximately 20 percent of Brugada Syndrome patients with rare S. C. N. five A variants.
Article number four. Cirrhotic Cardiomyopathy Predicts New-onset Heart Failure Within the First Year After Liver Transplantation. This retrospective cohort study found that cirrhotic cardiomyopathy predicts new-onset heart failure within the first year following liver transplantation. The study identified an association between cirrhotic cardiomyopathy, defined using the Cirrhotic Cardiomyopathy Consortium 2020 criteria, and major adverse cardiovascular events after liver transplantation. This established the significant impact of cirrhotic cardiomyopathy on post-transplant cardiac outcomes. These results demonstrate that pre-transplant cardiac assessment for cirrhotic cardiomyopathy is crucial for identifying patients at high risk for developing heart failure after liver transplantation.
Article number five. Role of physician assistants and their impact on cardiology specialty training in the United Kingdom. This study assessed the role and impact of physician assistants on cardiology specialty training in the United Kingdom by surveying resident doctors. The findings described the current scope of practice for physician assistants within U. K. cardiology, addressing previously undefined roles. The study evaluated the impact of physician assistant expansion on resident doctor training, directly responding to concerns regarding patient safety and training quality. These results provide clarity on the evolving roles of physician assistants in cardiology and their implications for junior cardiologist education and development.
Thank you for listening. Don’t forget to subscribe.
Keywords
precision medicine, temporal trends, CD4 positive T regulatory cells, Physician assistants, scope of practice, Brugada Syndrome, Oral anticoagulants, new-onset heart failure, epigenomic remodeling, Cirrhotic cardiomyopathy, United Kingdom healthcare, clinical outcomes, post-transplant outcomes, heart regeneration, cardiac growth, cardiology training, automated patch clamp, S. C. N. five A variants, atrial fibrillation, liver transplantation, variant classification, resident doctors, cardiomyocytes, major adverse cardiovascular events, elderly patients.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post Cirrhotic Cardiomyopathy Predicts Post-Transplant Heart Failure 11/18/25 first appeared on Cardiology Today.
Article Links:
Article 1: CD4+ Tregs Regulate Heart Growth and Regeneration Through MRG15/TIP60-Mediated Epigenomic Remodeling in Proliferating Cardiomyocytes. (Circulation)
Article 2: Temporal trends in the use of oral anticoagulants and clinical outcomes in older, elderly, and very elderly patients with atrial fibrillation: a Danish nationwide study. (European heart journal)
Article 3: Automated patch clamp data improve variant classification and penetrance stratification for SCN5A-Brugada syndrome. (European heart journal)
Article 4: Cirrhotic Cardiomyopathy Predicts New-onset Heart Failure Within the First Year After Liver Transplantation. (Transplantation)
Article 5: Role of physician assistants and their impact on cardiology specialty training in the United Kingdom. (Heart (British Cardiac Society))
Full episode page: https://podcast.explainheart.com/podcast/cirrhotic-cardiomyopathy-predicts-post-transplant-heart-failure-11-18-25/
Featured Articles
Article 1: CD4+ Tregs Regulate Heart Growth and Regeneration Through MRG15/TIP60-Mediated Epigenomic Remodeling in Proliferating Cardiomyocytes.
Journal: Circulation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41251000
Summary: The study demonstrated that CD4 positive T regulatory cells regulate heart growth and regeneration. This regulation occurs through M. R. G. fifteen / T. I. P. sixty mediated epigenomic remodeling within proliferating cardiomyocytes. The chromatin regulatory network was found to be crucial in orchestrating the dynamic changes in gene expression for the regenerative response in the neonatal heart. These findings provide a deeper understanding of the mechanisms controlling heart regeneration, which is critical for addressing limited regenerative capacity in the adult mammalian heart.
Article 2: Temporal trends in the use of oral anticoagulants and clinical outcomes in older, elderly, and very elderly patients with atrial fibrillation: a Danish nationwide study.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41251006
Summary: This nationwide Danish study analyzed temporal trends in the use of oral anticoagulants and associated clinical outcomes in older patients with new-onset atrial fibrillation. The study found that anticoagulation therapy patterns in patients with atrial fibrillation have evolved significantly over time, especially following the introduction of direct oral anticoagulants. The analysis investigated how these changes in anticoagulant uptake have impacted clinical outcomes across older adults (65-74 years), elderly (75-84 years), and very elderly (85 years and older) patient groups. This provides critical information on how treatment strategies and patient prognoses for atrial fibrillation have shifted in an aging population.
Article 3: Automated patch clamp data improve variant classification and penetrance stratification for SCN5A-Brugada syndrome.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41251004
Summary: The study demonstrated that automated patch clamp data significantly improves the classification of S. C. N. five A variants and penetrance stratification for Brugada Syndrome. This approach addresses complications in genetic workup arising from S. C. N. five A variants of uncertain significance and incomplete penetrance. The deployment of an S. C. N. five A Brugada Syndrome functional assay at a cohort scale was found to facilitate the implementation of genetic and precision medicine for this inherited arrhythmia disorder. These findings refine the diagnostic and risk stratification process for the approximately 20 percent of Brugada Syndrome patients with rare S. C. N. five A variants.
Article 4: Cirrhotic Cardiomyopathy Predicts New-onset Heart Failure Within the First Year After Liver Transplantation.
Journal: Transplantation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41247366
Summary: This retrospective cohort study found that cirrhotic cardiomyopathy predicts new-onset heart failure within the first year following liver transplantation. The study identified an association between cirrhotic cardiomyopathy, defined using the Cirrhotic Cardiomyopathy Consortium 2020 criteria, and major adverse cardiovascular events after liver transplantation. This established the significant impact of cirrhotic cardiomyopathy on post-transplant cardiac outcomes. These results demonstrate that pre-transplant cardiac assessment for cirrhotic cardiomyopathy is crucial for identifying patients at high risk for developing heart failure after liver transplantation.
Article 5: Role of physician assistants and their impact on cardiology specialty training in the United Kingdom.
Journal: Heart (British Cardiac Society)
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41249040
Summary: This study assessed the role and impact of physician assistants on cardiology specialty training in the United Kingdom by surveying resident doctors. The findings described the current scope of practice for physician assistants within U. K. cardiology, addressing previously undefined roles. The study evaluated the impact of physician assistant expansion on resident doctor training, directly responding to concerns regarding patient safety and training quality. These results provide clarity on the evolving roles of physician assistants in cardiology and their implications for junior cardiologist education and development.
Transcript
Today’s date is November 18, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. CD4+ Tregs Regulate Heart Growth and Regeneration Through MRG15/TIP60-Mediated Epigenomic Remodeling in Proliferating Cardiomyocytes. The study demonstrated that CD4 positive T regulatory cells regulate heart growth and regeneration. This regulation occurs through M. R. G. fifteen / T. I. P. sixty mediated epigenomic remodeling within proliferating cardiomyocytes. The chromatin regulatory network was found to be crucial in orchestrating the dynamic changes in gene expression for the regenerative response in the neonatal heart. These findings provide a deeper understanding of the mechanisms controlling heart regeneration, which is critical for addressing limited regenerative capacity in the adult mammalian heart.
Article number two. Temporal trends in the use of oral anticoagulants and clinical outcomes in older, elderly, and very elderly patients with atrial fibrillation: a Danish nationwide study. This nationwide Danish study analyzed temporal trends in the use of oral anticoagulants and associated clinical outcomes in older patients with new-onset atrial fibrillation. The study found that anticoagulation therapy patterns in patients with atrial fibrillation have evolved significantly over time, especially following the introduction of direct oral anticoagulants. The analysis investigated how these changes in anticoagulant uptake have impacted clinical outcomes across older adults (65-74 years), elderly (75-84 years), and very elderly (85 years and older) patient groups. This provides critical information on how treatment strategies and patient prognoses for atrial fibrillation have shifted in an aging population.
Article number three. Automated patch clamp data improve variant classification and penetrance stratification for SCN5A-Brugada syndrome. The study demonstrated that automated patch clamp data significantly improves the classification of S. C. N. five A variants and penetrance stratification for Brugada Syndrome. This approach addresses complications in genetic workup arising from S. C. N. five A variants of uncertain significance and incomplete penetrance. The deployment of an S. C. N. five A Brugada Syndrome functional assay at a cohort scale was found to facilitate the implementation of genetic and precision medicine for this inherited arrhythmia disorder. These findings refine the diagnostic and risk stratification process for the approximately 20 percent of Brugada Syndrome patients with rare S. C. N. five A variants.
Article number four. Cirrhotic Cardiomyopathy Predicts New-onset Heart Failure Within the First Year After Liver Transplantation. This retrospective cohort study found that cirrhotic cardiomyopathy predicts new-onset heart failure within the first year following liver transplantation. The study identified an association between cirrhotic cardiomyopathy, defined using the Cirrhotic Cardiomyopathy Consortium 2020 criteria, and major adverse cardiovascular events after liver transplantation. This established the significant impact of cirrhotic cardiomyopathy on post-transplant cardiac outcomes. These results demonstrate that pre-transplant cardiac assessment for cirrhotic cardiomyopathy is crucial for identifying patients at high risk for developing heart failure after liver transplantation.
Article number five. Role of physician assistants and their impact on cardiology specialty training in the United Kingdom. This study assessed the role and impact of physician assistants on cardiology specialty training in the United Kingdom by surveying resident doctors. The findings described the current scope of practice for physician assistants within U. K. cardiology, addressing previously undefined roles. The study evaluated the impact of physician assistant expansion on resident doctor training, directly responding to concerns regarding patient safety and training quality. These results provide clarity on the evolving roles of physician assistants in cardiology and their implications for junior cardiologist education and development.
Thank you for listening. Don’t forget to subscribe.
Keywords
precision medicine, temporal trends, CD4 positive T regulatory cells, Physician assistants, scope of practice, Brugada Syndrome, Oral anticoagulants, new-onset heart failure, epigenomic remodeling, Cirrhotic cardiomyopathy, United Kingdom healthcare, clinical outcomes, post-transplant outcomes, heart regeneration, cardiac growth, cardiology training, automated patch clamp, S. C. N. five A variants, atrial fibrillation, liver transplantation, variant classification, resident doctors, cardiomyocytes, major adverse cardiovascular events, elderly patients.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post Cirrhotic Cardiomyopathy Predicts Post-Transplant Heart Failure 11/18/25 first appeared on Cardiology Today.
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