Build Your Pro Metabolic Diet: https://mikefave.com/92925-ENERGY Work With Me: https://mikefave.com//92925-COACHING Dr. Chris Knobbe's channel: https://www.youtube.com/@UCyRSoypSQDgCyYWmiWtOKgg Time Stamps: 00:00 - Is saturated fat really the main culprit in heart disease? 02:07 - Heart disease was rare in the 19th century 07:15 - Sir William Osler and the first U.S. heart attack cases 18:07 - Coronary deaths explode from 1912 through the 1970s 25:16 - Seed oil consumption rises alongside heart disease 28:33 - Smoking decline, medical advances, but heart disease remains #1 killer 35:18 - How atherosclerosis develops and the role of oxidized LDL 46:43 - Linoleic acid makes LDL vulnerable to oxidation 53:38 - Why LDL alone cannot explain heart disease trends 58:22 - PUFA instability and lipid peroxidation risks 1:05:16 - High cholesterol but zero heart disease: Chris's testimonial 1:11:01 - Processed foods, seed oils, and antioxidant depletion 1:17:45 - USDA data: dramatic rise in linoleic acid since 1909 1:24:23 - Where linoleic acid comes from: seed oils vs ancestral fats 1:28:03 - Saturated fat intake stayed flat while heart disease rose 1:30:04 - Ancel Keys, the lipid hypothesis, and dietary guidelines 1:37:29 - How PUFA lower cholesterol (SREBP and PPAR pathways) 1:44:39 - Cutting linoleic acid lowers oxidized metabolites in weeks 1:53:02 - Seed oils linked to obesity, diabetes, and metabolic dysfunction 1:56:14 - Final takeaways: avoid industrial seed oils, return to ancestral fats

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