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Listen "Episode 24 | Insights from an Analgesic Ketamine Study with Dr. Rachael Alionhart"
Episode Synopsis
Ketamine is an under-studied option for analgesic anesthesia. During this episode, we learn more about it from Dr. Rachael Alionhart, a Clinical Veterinarian with the Department of Comparative Medicine at the Oregon Health & Science University. Rachael recently completed her lab animal training program and has a DVM and MS from the Cummings School of Veterinary Medicine at Tufts University. She joins us to discuss her recent JAAALS-accepted paper titled: The Effects of Subcutaneous Ketamine on Postlaparotomy Analgesia and Behavior in Female Sprague-Dawley Rats. Tune in for an in-depth look at the study hypothesis, process, findings, and insights, along with some key words of wisdom for anyone looking to do a similar study on analgesics in animals. Want to know more about rodent anesthesia and analgesia? This episode is for you! Key Points From This Episode: Dr. Rachael Alionhart's journey to her current role as a clinical veterinarian. What sparked her interest in the topic of ketamine treatment and analgesia. Behind the scenes of her study: The Effects of Subcutaneous Ketamine on Postlaparotomy Analgesia and Behavior in Female Sprague-Dawley Rats How to assess whether or not a drug is working effectively. Methods to evaluate pain in rats and mice. Rachael's first hypothesis and how it was addressed. The four different treatment groups she based her study on. More on the study design, dosage, and treatment groups. Insights on the benefits of ketamine from the study. Rachael's feces collection process and how pica arose during the trial. Using a video correlation to get an accurate sense of pain. Why she recommends meloxicam ER over buprenorphine ER for Sprague-Dawley females. Insights on male rats versus female rats. Advice for anyone looking to do an analgesic study on rats. Links Mentioned in Today's Episode: Dr. Rachael Alionhart on LinkedInThe Effects of Subcutaneous Ketamine on Postlaparotomy Analgesia and Behavior in Female Sprague–Dawley RatsAmerican Association for Laboratory Animal Science (AALAS) Journal of the American Association for Laboratory Animal Science (JAALAS)The LASt Word: An AALAS Podcast
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