New agents in veterinary anesthesia are changing the game. In this episode, we explore Grapiprant, a groundbreaking nonsteroidal anti-inflammatory drug (NSAID) from the newer piprant class. We are joined by Dr. Lauren Wierenga, DVM, a staff veterinarian at Northern Bio. With a veterinary degree from the University of Wisconsin and lab animal residency training from the Wisconsin National Primate Research Center, Dr. Wierenga brings a wealth of expertise. She's here to discuss her recent JAALAS paper, 'Single-Dose Pharmacokinetics of Grapiprant in Rhesus Macaques'. Tune in to hear her elaborate on the importance of NSAIDs in treatment approaches, why and how she chose to tailor and design this PK study, and the findings and limitations of her work. She discusses how patient age may influence the drug's efficacy and also shares different aspects that surprised her during the process of the project. Dr. Wierenga also shares her final thoughts on the safety and effectiveness of Grapiprant and its potential role in a multimodal pain management approach. For more insightful findings, be sure to tune into this episode of the LASt Word Podcast.   Key Points From This Episode: We are introduced to today's guest, Lauren Wierenga, DVM. The story of how she got into lab animal research. Dr. Wierenga details the team members she worked with on this project. We dive into the introduction of her paper and why NSAIDs are so important. The basics of the NSAIDs rolling cascade. Dr. Wierenga unpacks the best approach for a Pharmacokinetics (PK) study design. We delve into the study's findings and what surprised Dr. Wierenga within their discoveries. The highlights of the paper's discussion. Other interesting findings that came from the study, and we explore the possible limitations. How age played a role in the effectiveness of the drug. Her thoughts on using this drug in a multimodal approach. Dr. Wierenge imparts advice to anyone looking to make use of Gripiprant in their clinics.   Links Mentioned in Today's Episode: Dr. Lauren Wierenga, DVM on LinkedIn 'Single-Dose Pharmacokinetics of Grapiprant in Rhesus Macaques' American Association for Laboratory Animal Science (AALAS) Journal of the American Association for Laboratory Animal Science (JAALAS)The LASt Word: An AALAS Podcast

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