On this episode, Dr. Mani Alavi and I discuss mismatched disease and its impact on human health. We also explore the concept of mismatched disease and its relationship to the modern environment. Dr. Mani talks about the impact processed foods have on our health, the reasons behind the higher rates of chronic illnesses in America, and the role of physical activity in preventing mismatched disease. The conversation also provides insights for runners, emphasizing the importance of varied movement patterns, nutrition, and stress management. Episode Outline 00:00Introduction and Background of Dr. Mani Alavi11:02Definition and Origin of Mismatched Disease18:00The Impact of Agriculture and the Standard American Diet25:48The Evolution of Human Health and the Modern Environment29:44Introduction to Mismatched Disease30:11The Impact of Processed Foods31:27The Western Diet and Chronic Illnesses40:41Optimizing Training and Performance for Runners46:16Incorporating Evolutionary Principles into Lifestyle Choices57:32Finding Joy and Fun in Physical ActivityAbout Dr. ManiDr. Mani Alavi is an emergency medicine physician, former attorney, and an avid runner.  He has completed several world major marathons, with a particular fondness for the Boston Marathon, which holds a special place in his heart. Dr. Alavi specializes in heat science and mismatch disease, focusing on heat acclimation and training, and also topics related to mismatch disease, exploring how modern environments impact our health. Outside of medicine and running, he hosts the Adaptation by Fire podcast, where he discusses health, fitness, and optimizing performance in extreme conditions. Additionally, Dr. Alavi writes on these subjects. In his leisure time, he enjoys spending time with his family, coaching his children's soccer teams,  traveling, and enjoying the outdoors.Connect with Dr. [email protected] with Dr. KatInstagram-  @Runwithkat_dptTik-tok- @Runwithkat_dptFacebook Group- RunwithKat ShowWebsite- RunwithKat.net

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