Clinical Conundrum: What is the Utility of Procalcitonin in the ED?

REBEL EM – Emergency Medicine Blog
25/09/2025
Clinical Conundrum: What is the Utility of Procalcitonin in the ED?

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Episode Synopsis

Procalcitonin is a protein that is upregulated during inflammatory states. An elevation in procalcitonin should be specific to bacterial infections. Viral infections should result in decreased procalcitonin levels thus allowing us to differentiate bacterial from viral and help guide antibiotic prescription. However, this differentiation isn’t what we see in real life data.
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