Clinical Conundrum: Pregnant and Puking: What’s Safe and Effective in the ED?

10/12/2025
Clinical Conundrum: Pregnant and Puking: What’s Safe and Effective in the ED?

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Episode Synopsis

Nausea with or without vomiting is very common in early pregnancy, affecting approximately 70% of pregnancies (Maisal 2012). Hyperemesis gravidarum is a severe form of nausea and vomiting in pregnancy that can lead to significant maternal dehydration, electrolyte abnormalities, and weight loss if not properly managed. Pharmacologic treatment is crucial to break the cycle of vomiting, restore oral intake, and prevent complications such as Wernicke’s encephalopathy or hospitalization. Timely and effective treatment improves maternal quality of life, prevents adverse fetal outcomes related to malnutrition, and reduces the need for invasive interventions.
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