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Listen "T-TEER Safe in CIED Patients with Tricuspid Regurgitation 10/26/25"
Episode Synopsis
Welcome to Cardiology Today – Recorded October 26, 2025. This episode summarizes 5 key cardiology studies on topics like severe tricuspid regurgitation and cardiac implantable electronic devices. Key takeaway: T-TEER Safe in CIED Patients with Tricuspid Regurgitation.
Article Links:
Article 1: Left Atrial Appendage Occlusion Using a Novel System: Preclinical Evaluation and First-in-Human Experience. (JACC. Cardiovascular interventions)
Article 2: Impact of Valve Frame Height on PCI Outcomes After TAVR. (JACC. Cardiovascular interventions)
Article 3: Tricuspid Valve Transcatheter Edge-to-Edge Repair in Patients With Cardiac Implantable Electronic Devices: Insights From EuroTR. (JACC. Cardiovascular interventions)
Article 4: Transcatheter Tricuspid Valve Replacement and CLEFT After Tricuspid TEER. (JACC. Cardiovascular interventions)
Article 5: Comparative Outcomes of Intracardiac vs Transesophageal Echocardiographic Guidance for Left Atrial Appendage Occlusion: Insights From EMERGE LAA Postapproval Study. (JACC. Cardiovascular interventions)
Full episode page: https://podcast.explainheart.com/podcast/t-teer-safe-in-cied-patients-with-tricuspid-regurgitation-10-26-25/
Featured Articles
Article 1: Left Atrial Appendage Occlusion Using a Novel System: Preclinical Evaluation and First-in-Human Experience.
Journal: JACC. Cardiovascular interventions
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41137840
Summary: This study evaluated the safety and performance of the novel Zenith Left Atrial Appendage occlusion system through preclinical canine models and a prospective first-in-human experience. The research successfully established the system’s safety and effectiveness for occluding the left atrial appendage. This represents a significant advancement, offering a new percutaneous option for stroke prevention in patients with atrial fibrillation who are intolerant to long-term oral anticoagulation. The Zenith system aims to overcome limitations of current devices like device-related thrombus and peridevice leak.
Article 2: Impact of Valve Frame Height on PCI Outcomes After TAVR.
Journal: JACC. Cardiovascular interventions
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41137839
Summary: Outcomes After T.A.V.R. This multicenter registry study evaluated the impact of bioprosthetic aortic valve type on long-term clinical outcomes for patients undergoing percutaneous coronary intervention following transcatheter aortic valve replacement. Researchers utilized data from the R.E.V.I.V.A.L.-P.C.I. registry across 21 European centers. The findings provide crucial clarity regarding the challenges of coronary access after transcatheter aortic valve replacement, particularly with tall-framed valves. This research has significant clinical implications for informing valve selection during transcatheter aortic valve replacement to optimize future coronary revascularization strategies.
Article 3: Tricuspid Valve Transcatheter Edge-to-Edge Repair in Patients With Cardiac Implantable Electronic Devices: Insights From EuroTR.
Journal: JACC. Cardiovascular interventions
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41137838
Summary: This real-world cohort study, derived from the EuroT.R. registry, evaluated procedural and clinical outcomes of tricuspid valve transcatheter edge-to-edge repair in 851 patients with cardiac implantable electronic device leads. The research, conducted across 26 centers, characterized the previously unclear long-term outcomes in this specific patient population. The study established the safety and effectiveness of tricuspid valve transcatheter edge-to-edge repair even with the presence of transvalvular device leads. These findings significantly broaden the applicability of this minimally invasive treatment for severe tricuspid regurgitation in patients with complex cardiac histories.
Article 4: Transcatheter Tricuspid Valve Replacement and CLEFT After Tricuspid TEER.
Journal: JACC. Cardiovascular interventions
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41137837
Summary: After Tricuspid T-TEER. This study described the techniques and outcomes for patients undergoing transcatheter tricuspid valve replacement after prior tricuspid transcatheter edge-to-edge repair. The research elucidated advanced electrosurgical techniques, such as C.L.E.F., that facilitate successful transcatheter tricuspid valve replacement in these complex cases. This paper establishes the feasibility and provides important procedural guidance for patients with severe tricuspid regurgitation who do not achieve optimal results from initial edge-to-edge repair. These findings represent a significant contribution to the evolving treatment landscape for advanced tricuspid valve disease.
Article 5: Comparative Outcomes of Intracardiac vs Transesophageal Echocardiographic Guidance for Left Atrial Appendage Occlusion: Insights From EMERGE LAA Postapproval Study.
Journal: JACC. Cardiovascular interventions
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41137834
Summary: Postapproval Study. This study compared outcomes of left atrial appendage occlusion procedures guided by intracardiac echocardiography versus transesophageal echocardiography, or a combination of both. Utilizing data from the E.M.E.R.G.E. L.A.A. postapproval study, researchers analyzed patients with Amulet implants from the National Cardiovascular Data Registry Left Atrial Appendage Occlusion Registry. The findings provide critical comparative data on the efficacy and safety of different echocardiographic guidance modalities for these procedures. This research offers valuable clinical guidance for optimizing imaging strategies during left atrial appendage occlusion to enhance procedural outcomes and patient care.
Transcript
Today’s date is October 26, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Left Atrial Appendage Occlusion Using a Novel System: Preclinical Evaluation and First-in-Human Experience. This study evaluated the safety and performance of the novel Zenith Left Atrial Appendage occlusion system through preclinical canine models and a prospective first-in-human experience. The research successfully established the system’s safety and effectiveness for occluding the left atrial appendage. This represents a significant advancement, offering a new percutaneous option for stroke prevention in patients with atrial fibrillation who are intolerant to long-term oral anticoagulation. The Zenith system aims to overcome limitations of current devices like device-related thrombus and peridevice leak.
Article number two. Impact of Valve Frame Height on P.C.I. Outcomes After T.A.V.R. This multicenter registry study evaluated the impact of bioprosthetic aortic valve type on long-term clinical outcomes for patients undergoing percutaneous coronary intervention following transcatheter aortic valve replacement. Researchers utilized data from the R.E.V.I.V.A.L.-P.C.I. registry across 21 European centers. The findings provide crucial clarity regarding the challenges of coronary access after transcatheter aortic valve replacement, particularly with tall-framed valves. This research has significant clinical implications for informing valve selection during transcatheter aortic valve replacement to optimize future coronary revascularization strategies.
Article number three. Tricuspid Valve Transcatheter Edge-to-Edge Repair in Patients With Cardiac Implantable Electronic Devices: Insights From EuroTR. This real-world cohort study, derived from the EuroT.R. registry, evaluated procedural and clinical outcomes of tricuspid valve transcatheter edge-to-edge repair in 851 patients with cardiac implantable electronic device leads. The research, conducted across 26 centers, characterized the previously unclear long-term outcomes in this specific patient population. The study established the safety and effectiveness of tricuspid valve transcatheter edge-to-edge repair even with the presence of transvalvular device leads. These findings significantly broaden the applicability of this minimally invasive treatment for severe tricuspid regurgitation in patients with complex cardiac histories.
Article number four. Transcatheter Tricuspid Valve Replacement and C.L.E.F. After Tricuspid T-TEER. This study described the techniques and outcomes for patients undergoing transcatheter tricuspid valve replacement after prior tricuspid transcatheter edge-to-edge repair. The research elucidated advanced electrosurgical techniques, such as C.L.E.F., that facilitate successful transcatheter tricuspid valve replacement in these complex cases. This paper establishes the feasibility and provides important procedural guidance for patients with severe tricuspid regurgitation who do not achieve optimal results from initial edge-to-edge repair. These findings represent a significant contribution to the evolving treatment landscape for advanced tricuspid valve disease.
Article number five. Comparative Outcomes of Intracardiac vs Transesophageal Echocardiographic Guidance for Left Atrial Appendage Occlusion: Insights From EMERGE L.A.A. Postapproval Study. This study compared outcomes of left atrial appendage occlusion procedures guided by intracardiac echocardiography versus transesophageal echocardiography, or a combination of both. Utilizing data from the E.M.E.R.G.E. L.A.A. postapproval study, researchers analyzed patients with Amulet implants from the National Cardiovascular Data Registry Left Atrial Appendage Occlusion Registry. The findings provide critical comparative data on the efficacy and safety of different echocardiographic guidance modalities for these procedures. This research offers valuable clinical guidance for optimizing imaging strategies during left atrial appendage occlusion to enhance procedural outcomes and patient care.
Thank you for listening. Don’t forget to subscribe.
Keywords
severe tricuspid regurgitation, cardiac implantable electronic devices, tricuspid transcatheter edge-to-edge repair, electrosurgical techniques, Zenith system, percutaneous intervention, stroke risk, transesophageal echocardiography, EuroT.R. registry, bioprosthetic aortic valve, procedural outcomes, tall-framed valves, imaging guidance, left atrial appendage occlusion, tricuspid valve transcatheter edge-to-edge repair, Left Atrial Appendage occlusion, atrial fibrillation, transcatheter aortic valve replacement, Amulet implant, percutaneous coronary intervention, transcatheter tricuspid valve replacement, C.L.E.F., coronary access, intracardiac echocardiography.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post T-TEER Safe in CIED Patients with Tricuspid Regurgitation 10/26/25 first appeared on Cardiology Today.
Article Links:
Article 1: Left Atrial Appendage Occlusion Using a Novel System: Preclinical Evaluation and First-in-Human Experience. (JACC. Cardiovascular interventions)
Article 2: Impact of Valve Frame Height on PCI Outcomes After TAVR. (JACC. Cardiovascular interventions)
Article 3: Tricuspid Valve Transcatheter Edge-to-Edge Repair in Patients With Cardiac Implantable Electronic Devices: Insights From EuroTR. (JACC. Cardiovascular interventions)
Article 4: Transcatheter Tricuspid Valve Replacement and CLEFT After Tricuspid TEER. (JACC. Cardiovascular interventions)
Article 5: Comparative Outcomes of Intracardiac vs Transesophageal Echocardiographic Guidance for Left Atrial Appendage Occlusion: Insights From EMERGE LAA Postapproval Study. (JACC. Cardiovascular interventions)
Full episode page: https://podcast.explainheart.com/podcast/t-teer-safe-in-cied-patients-with-tricuspid-regurgitation-10-26-25/
Featured Articles
Article 1: Left Atrial Appendage Occlusion Using a Novel System: Preclinical Evaluation and First-in-Human Experience.
Journal: JACC. Cardiovascular interventions
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41137840
Summary: This study evaluated the safety and performance of the novel Zenith Left Atrial Appendage occlusion system through preclinical canine models and a prospective first-in-human experience. The research successfully established the system’s safety and effectiveness for occluding the left atrial appendage. This represents a significant advancement, offering a new percutaneous option for stroke prevention in patients with atrial fibrillation who are intolerant to long-term oral anticoagulation. The Zenith system aims to overcome limitations of current devices like device-related thrombus and peridevice leak.
Article 2: Impact of Valve Frame Height on PCI Outcomes After TAVR.
Journal: JACC. Cardiovascular interventions
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41137839
Summary: Outcomes After T.A.V.R. This multicenter registry study evaluated the impact of bioprosthetic aortic valve type on long-term clinical outcomes for patients undergoing percutaneous coronary intervention following transcatheter aortic valve replacement. Researchers utilized data from the R.E.V.I.V.A.L.-P.C.I. registry across 21 European centers. The findings provide crucial clarity regarding the challenges of coronary access after transcatheter aortic valve replacement, particularly with tall-framed valves. This research has significant clinical implications for informing valve selection during transcatheter aortic valve replacement to optimize future coronary revascularization strategies.
Article 3: Tricuspid Valve Transcatheter Edge-to-Edge Repair in Patients With Cardiac Implantable Electronic Devices: Insights From EuroTR.
Journal: JACC. Cardiovascular interventions
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41137838
Summary: This real-world cohort study, derived from the EuroT.R. registry, evaluated procedural and clinical outcomes of tricuspid valve transcatheter edge-to-edge repair in 851 patients with cardiac implantable electronic device leads. The research, conducted across 26 centers, characterized the previously unclear long-term outcomes in this specific patient population. The study established the safety and effectiveness of tricuspid valve transcatheter edge-to-edge repair even with the presence of transvalvular device leads. These findings significantly broaden the applicability of this minimally invasive treatment for severe tricuspid regurgitation in patients with complex cardiac histories.
Article 4: Transcatheter Tricuspid Valve Replacement and CLEFT After Tricuspid TEER.
Journal: JACC. Cardiovascular interventions
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41137837
Summary: After Tricuspid T-TEER. This study described the techniques and outcomes for patients undergoing transcatheter tricuspid valve replacement after prior tricuspid transcatheter edge-to-edge repair. The research elucidated advanced electrosurgical techniques, such as C.L.E.F., that facilitate successful transcatheter tricuspid valve replacement in these complex cases. This paper establishes the feasibility and provides important procedural guidance for patients with severe tricuspid regurgitation who do not achieve optimal results from initial edge-to-edge repair. These findings represent a significant contribution to the evolving treatment landscape for advanced tricuspid valve disease.
Article 5: Comparative Outcomes of Intracardiac vs Transesophageal Echocardiographic Guidance for Left Atrial Appendage Occlusion: Insights From EMERGE LAA Postapproval Study.
Journal: JACC. Cardiovascular interventions
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41137834
Summary: Postapproval Study. This study compared outcomes of left atrial appendage occlusion procedures guided by intracardiac echocardiography versus transesophageal echocardiography, or a combination of both. Utilizing data from the E.M.E.R.G.E. L.A.A. postapproval study, researchers analyzed patients with Amulet implants from the National Cardiovascular Data Registry Left Atrial Appendage Occlusion Registry. The findings provide critical comparative data on the efficacy and safety of different echocardiographic guidance modalities for these procedures. This research offers valuable clinical guidance for optimizing imaging strategies during left atrial appendage occlusion to enhance procedural outcomes and patient care.
Transcript
Today’s date is October 26, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Left Atrial Appendage Occlusion Using a Novel System: Preclinical Evaluation and First-in-Human Experience. This study evaluated the safety and performance of the novel Zenith Left Atrial Appendage occlusion system through preclinical canine models and a prospective first-in-human experience. The research successfully established the system’s safety and effectiveness for occluding the left atrial appendage. This represents a significant advancement, offering a new percutaneous option for stroke prevention in patients with atrial fibrillation who are intolerant to long-term oral anticoagulation. The Zenith system aims to overcome limitations of current devices like device-related thrombus and peridevice leak.
Article number two. Impact of Valve Frame Height on P.C.I. Outcomes After T.A.V.R. This multicenter registry study evaluated the impact of bioprosthetic aortic valve type on long-term clinical outcomes for patients undergoing percutaneous coronary intervention following transcatheter aortic valve replacement. Researchers utilized data from the R.E.V.I.V.A.L.-P.C.I. registry across 21 European centers. The findings provide crucial clarity regarding the challenges of coronary access after transcatheter aortic valve replacement, particularly with tall-framed valves. This research has significant clinical implications for informing valve selection during transcatheter aortic valve replacement to optimize future coronary revascularization strategies.
Article number three. Tricuspid Valve Transcatheter Edge-to-Edge Repair in Patients With Cardiac Implantable Electronic Devices: Insights From EuroTR. This real-world cohort study, derived from the EuroT.R. registry, evaluated procedural and clinical outcomes of tricuspid valve transcatheter edge-to-edge repair in 851 patients with cardiac implantable electronic device leads. The research, conducted across 26 centers, characterized the previously unclear long-term outcomes in this specific patient population. The study established the safety and effectiveness of tricuspid valve transcatheter edge-to-edge repair even with the presence of transvalvular device leads. These findings significantly broaden the applicability of this minimally invasive treatment for severe tricuspid regurgitation in patients with complex cardiac histories.
Article number four. Transcatheter Tricuspid Valve Replacement and C.L.E.F. After Tricuspid T-TEER. This study described the techniques and outcomes for patients undergoing transcatheter tricuspid valve replacement after prior tricuspid transcatheter edge-to-edge repair. The research elucidated advanced electrosurgical techniques, such as C.L.E.F., that facilitate successful transcatheter tricuspid valve replacement in these complex cases. This paper establishes the feasibility and provides important procedural guidance for patients with severe tricuspid regurgitation who do not achieve optimal results from initial edge-to-edge repair. These findings represent a significant contribution to the evolving treatment landscape for advanced tricuspid valve disease.
Article number five. Comparative Outcomes of Intracardiac vs Transesophageal Echocardiographic Guidance for Left Atrial Appendage Occlusion: Insights From EMERGE L.A.A. Postapproval Study. This study compared outcomes of left atrial appendage occlusion procedures guided by intracardiac echocardiography versus transesophageal echocardiography, or a combination of both. Utilizing data from the E.M.E.R.G.E. L.A.A. postapproval study, researchers analyzed patients with Amulet implants from the National Cardiovascular Data Registry Left Atrial Appendage Occlusion Registry. The findings provide critical comparative data on the efficacy and safety of different echocardiographic guidance modalities for these procedures. This research offers valuable clinical guidance for optimizing imaging strategies during left atrial appendage occlusion to enhance procedural outcomes and patient care.
Thank you for listening. Don’t forget to subscribe.
Keywords
severe tricuspid regurgitation, cardiac implantable electronic devices, tricuspid transcatheter edge-to-edge repair, electrosurgical techniques, Zenith system, percutaneous intervention, stroke risk, transesophageal echocardiography, EuroT.R. registry, bioprosthetic aortic valve, procedural outcomes, tall-framed valves, imaging guidance, left atrial appendage occlusion, tricuspid valve transcatheter edge-to-edge repair, Left Atrial Appendage occlusion, atrial fibrillation, transcatheter aortic valve replacement, Amulet implant, percutaneous coronary intervention, transcatheter tricuspid valve replacement, C.L.E.F., coronary access, intracardiac echocardiography.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post T-TEER Safe in CIED Patients with Tricuspid Regurgitation 10/26/25 first appeared on Cardiology Today.
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