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Listen "Prognostic Markers for Recovered E.F. Heart Failure 11/04/25"
Episode Synopsis
Welcome to Cardiology Today – Recorded November 04, 2025. This episode summarizes 5 key cardiology studies on topics like s.P.A.P. and evolocumab. Key takeaway: Prognostic Markers for Recovered E.F. Heart Failure.
Article Links:
Article 1: Randomized Controlled Trial of Mechanical Thrombectomy With Anticoagulation Versus Anticoagulation Alone for Acute Intermediate-High Risk Pulmonary Embolism: Primary Outcomes from the STORM-PE Trial. (Circulation)
Article 2: Prognostic Value of Exercise Right Ventricular-Pulmonary Arterial Coupling in Primary Mitral Regurgitation. (Circulation)
Article 3: Efficacy and Safety of Very Low Achieved LDL-Cholesterol in Patients with Prior Ischemic Stroke. (Circulation)
Article 4: Circulating Extracellular Vesicles in the Pathogenesis of Heart Failure in Patients with Chronic Kidney Disease. (Circulation)
Article 5: Prognostic Value of Natriuretic Peptide Levels in Heart Failure With Recovered Ejection Fraction. (Circulation. Heart failure)
Full episode page: https://podcast.explainheart.com/podcast/prognostic-markers-for-recovered-e-f-heart-failure-11-04-25/
Featured Articles
Article 1: Randomized Controlled Trial of Mechanical Thrombectomy With Anticoagulation Versus Anticoagulation Alone for Acute Intermediate-High Risk Pulmonary Embolism: Primary Outcomes from the STORM-PE Trial.
Journal: Circulation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41183181
Summary: The S.T.O.R.M.-P.E. trial conducted the first reported randomized controlled trial to evaluate the efficacy and safety of mechanical thrombectomy, specifically computer assisted vacuum thrombectomy, combined with anticoagulation versus anticoagulation alone for acute intermediate-high risk pulmonary embolism. This trial focused on patients with an elevated right ventricular to left ventricular diameter ratio, who are at increased risk of early clinical decompensation and mortality. By rigorously comparing these treatment strategies, the study established foundational data on whether mechanical thrombectomy can effectively relieve acute right ventricular pressure overload and normalize hemodynamics to improve patient outcomes.
Article 2: Prognostic Value of Exercise Right Ventricular-Pulmonary Arterial Coupling in Primary Mitral Regurgitation.
Journal: Circulation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41178584
Summary: This international multicenter cohort study aimed to evaluate the prognostic value of right ventricular-pulmonary arterial coupling in patients with primary mitral regurgitation. The study specifically assessed this coupling by measuring the ratio of tricuspid annular plane systolic excursion to systolic pulmonary artery pressure, both at rest and during exercise. By undertaking this comprehensive evaluation, the research established whether these non-invasive metrics provide a critical tool for risk stratification and improved management of patients with clinically significant primary mitral regurgitation.
Article 3: Efficacy and Safety of Very Low Achieved LDL-Cholesterol in Patients with Prior Ischemic Stroke.
Journal: Circulation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41178569
Summary: This study investigated the efficacy and safety of achieving very low levels of low-density lipoproteins-cholesterol in patients with a history of ischemic stroke. Analyzing data from the F.O.U.R.I.E.R. trial, which studied evolocumab in stable atherosclerotic cardiovascular disease, researchers determined the impact of intensive L.D.L.-C reduction on recurrent stroke and other major adverse cardiovascular events. The findings provide crucial clarity on optimizing lipid management strategies for this high-risk patient population, aiming to improve secondary prevention outcomes following ischemic stroke.
Article 4: Circulating Extracellular Vesicles in the Pathogenesis of Heart Failure in Patients with Chronic Kidney Disease.
Journal: Circulation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41178538
Summary: This cross-sectional study investigated the role of circulating extracellular vesicles in mediating pathological kidney-heart crosstalk, which contributes to heart failure development in patients with chronic kidney disease. Recognizing that cardiovascular disease is a leading cause of death in chronic kidney disease patients and kidney-derived factors are implicated, the research aimed to identify specific humoral risk factors. By elucidating the mechanism through which these vesicles facilitate direct cardiotoxicity, the study provides a foundational understanding to potentially identify novel therapeutic targets for heart failure in this vulnerable population.
Article 5: Prognostic Value of Natriuretic Peptide Levels in Heart Failure With Recovered Ejection Fraction.
Journal: Circulation. Heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41178541
Summary: This retrospective cohort study, spanning from 2009 to 2024 and including 3935 patients, investigated the prognostic value of N-terminal pro-B-type natriuretic peptide levels in individuals with heart failure and recovered left ventricular ejection fraction. The research aimed to determine if N.T.-proB.N.P. measured at the time of left ventricular ejection fraction recovery is an independent predictor of future adverse outcomes. By establishing a robust clinical marker for prognosis in this patient group, the study provides an essential tool for risk stratification and guiding management strategies where such markers are currently lacking.
Transcript
Today’s date is November 04, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Randomized Controlled Trial of Mechanical Thrombectomy With Anticoagulation Versus Anticoagulation Alone for Acute Intermediate-High Risk Pulmonary Embolism: Primary Outcomes from the STORM-PE Trial. The S.T.O.R.M.-P.E. trial conducted the first reported randomized controlled trial to evaluate the efficacy and safety of mechanical thrombectomy, specifically computer assisted vacuum thrombectomy, combined with anticoagulation versus anticoagulation alone for acute intermediate-high risk pulmonary embolism. This trial focused on patients with an elevated right ventricular to left ventricular diameter ratio, who are at increased risk of early clinical decompensation and mortality. By rigorously comparing these treatment strategies, the study established foundational data on whether mechanical thrombectomy can effectively relieve acute right ventricular pressure overload and normalize hemodynamics to improve patient outcomes.
Article number two. Prognostic Value of Exercise Right Ventricular-Pulmonary Arterial Coupling in Primary Mitral Regurgitation. This international multicenter cohort study aimed to evaluate the prognostic value of right ventricular-pulmonary arterial coupling in patients with primary mitral regurgitation. The study specifically assessed this coupling by measuring the ratio of tricuspid annular plane systolic excursion to systolic pulmonary artery pressure, both at rest and during exercise. By undertaking this comprehensive evaluation, the research established whether these non-invasive metrics provide a critical tool for risk stratification and improved management of patients with clinically significant primary mitral regurgitation.
Article number three. Efficacy and Safety of Very Low Achieved LDL-Cholesterol in Patients with Prior Ischemic Stroke. This study investigated the efficacy and safety of achieving very low levels of low-density lipoproteins-cholesterol in patients with a history of ischemic stroke. Analyzing data from the F.O.U.R.I.E.R. trial, which studied evolocumab in stable atherosclerotic cardiovascular disease, researchers determined the impact of intensive L.D.L.-C reduction on recurrent stroke and other major adverse cardiovascular events. The findings provide crucial clarity on optimizing lipid management strategies for this high-risk patient population, aiming to improve secondary prevention outcomes following ischemic stroke.
Article number four. Circulating Extracellular Vesicles in the Pathogenesis of Heart Failure in Patients with Chronic Kidney Disease. This cross-sectional study investigated the role of circulating extracellular vesicles in mediating pathological kidney-heart crosstalk, which contributes to heart failure development in patients with chronic kidney disease. Recognizing that cardiovascular disease is a leading cause of death in chronic kidney disease patients and kidney-derived factors are implicated, the research aimed to identify specific humoral risk factors. By elucidating the mechanism through which these vesicles facilitate direct cardiotoxicity, the study provides a foundational understanding to potentially identify novel therapeutic targets for heart failure in this vulnerable population.
Article number five. Prognostic Value of Natriuretic Peptide Levels in Heart Failure With Recovered Ejection Fraction. This retrospective cohort study, spanning from 2009 to 2024 and including 3935 patients, investigated the prognostic value of N-terminal pro-B-type natriuretic peptide levels in individuals with heart failure and recovered left ventricular ejection fraction. The research aimed to determine if N.T.-proB.N.P. measured at the time of left ventricular ejection fraction recovery is an independent predictor of future adverse outcomes. By establishing a robust clinical marker for prognosis in this patient group, the study provides an essential tool for risk stratification and guiding management strategies where such markers are currently lacking.
Thank you for listening. Don’t forget to subscribe.
Keywords
s.P.A.P., evolocumab, left ventricular ejection fraction, anticoagulation, heart failure, L.D.L.-C, mitral regurgitation, T.A.P.S.E., kidney-heart crosstalk, ischemic stroke, recovered ejection fraction, M.A.C.E., extracellular vesicles, recurrent stroke, cardiotoxicity, prognosis, mechanical thrombectomy, chronic kidney disease, pulmonary embolism, right ventricular, intermediate-high risk, N.T.-proB.N.P., right ventricular-pulmonary arterial coupling.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post Prognostic Markers for Recovered E.F. Heart Failure 11/04/25 first appeared on Cardiology Today.
Article Links:
Article 1: Randomized Controlled Trial of Mechanical Thrombectomy With Anticoagulation Versus Anticoagulation Alone for Acute Intermediate-High Risk Pulmonary Embolism: Primary Outcomes from the STORM-PE Trial. (Circulation)
Article 2: Prognostic Value of Exercise Right Ventricular-Pulmonary Arterial Coupling in Primary Mitral Regurgitation. (Circulation)
Article 3: Efficacy and Safety of Very Low Achieved LDL-Cholesterol in Patients with Prior Ischemic Stroke. (Circulation)
Article 4: Circulating Extracellular Vesicles in the Pathogenesis of Heart Failure in Patients with Chronic Kidney Disease. (Circulation)
Article 5: Prognostic Value of Natriuretic Peptide Levels in Heart Failure With Recovered Ejection Fraction. (Circulation. Heart failure)
Full episode page: https://podcast.explainheart.com/podcast/prognostic-markers-for-recovered-e-f-heart-failure-11-04-25/
Featured Articles
Article 1: Randomized Controlled Trial of Mechanical Thrombectomy With Anticoagulation Versus Anticoagulation Alone for Acute Intermediate-High Risk Pulmonary Embolism: Primary Outcomes from the STORM-PE Trial.
Journal: Circulation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41183181
Summary: The S.T.O.R.M.-P.E. trial conducted the first reported randomized controlled trial to evaluate the efficacy and safety of mechanical thrombectomy, specifically computer assisted vacuum thrombectomy, combined with anticoagulation versus anticoagulation alone for acute intermediate-high risk pulmonary embolism. This trial focused on patients with an elevated right ventricular to left ventricular diameter ratio, who are at increased risk of early clinical decompensation and mortality. By rigorously comparing these treatment strategies, the study established foundational data on whether mechanical thrombectomy can effectively relieve acute right ventricular pressure overload and normalize hemodynamics to improve patient outcomes.
Article 2: Prognostic Value of Exercise Right Ventricular-Pulmonary Arterial Coupling in Primary Mitral Regurgitation.
Journal: Circulation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41178584
Summary: This international multicenter cohort study aimed to evaluate the prognostic value of right ventricular-pulmonary arterial coupling in patients with primary mitral regurgitation. The study specifically assessed this coupling by measuring the ratio of tricuspid annular plane systolic excursion to systolic pulmonary artery pressure, both at rest and during exercise. By undertaking this comprehensive evaluation, the research established whether these non-invasive metrics provide a critical tool for risk stratification and improved management of patients with clinically significant primary mitral regurgitation.
Article 3: Efficacy and Safety of Very Low Achieved LDL-Cholesterol in Patients with Prior Ischemic Stroke.
Journal: Circulation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41178569
Summary: This study investigated the efficacy and safety of achieving very low levels of low-density lipoproteins-cholesterol in patients with a history of ischemic stroke. Analyzing data from the F.O.U.R.I.E.R. trial, which studied evolocumab in stable atherosclerotic cardiovascular disease, researchers determined the impact of intensive L.D.L.-C reduction on recurrent stroke and other major adverse cardiovascular events. The findings provide crucial clarity on optimizing lipid management strategies for this high-risk patient population, aiming to improve secondary prevention outcomes following ischemic stroke.
Article 4: Circulating Extracellular Vesicles in the Pathogenesis of Heart Failure in Patients with Chronic Kidney Disease.
Journal: Circulation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41178538
Summary: This cross-sectional study investigated the role of circulating extracellular vesicles in mediating pathological kidney-heart crosstalk, which contributes to heart failure development in patients with chronic kidney disease. Recognizing that cardiovascular disease is a leading cause of death in chronic kidney disease patients and kidney-derived factors are implicated, the research aimed to identify specific humoral risk factors. By elucidating the mechanism through which these vesicles facilitate direct cardiotoxicity, the study provides a foundational understanding to potentially identify novel therapeutic targets for heart failure in this vulnerable population.
Article 5: Prognostic Value of Natriuretic Peptide Levels in Heart Failure With Recovered Ejection Fraction.
Journal: Circulation. Heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41178541
Summary: This retrospective cohort study, spanning from 2009 to 2024 and including 3935 patients, investigated the prognostic value of N-terminal pro-B-type natriuretic peptide levels in individuals with heart failure and recovered left ventricular ejection fraction. The research aimed to determine if N.T.-proB.N.P. measured at the time of left ventricular ejection fraction recovery is an independent predictor of future adverse outcomes. By establishing a robust clinical marker for prognosis in this patient group, the study provides an essential tool for risk stratification and guiding management strategies where such markers are currently lacking.
Transcript
Today’s date is November 04, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Randomized Controlled Trial of Mechanical Thrombectomy With Anticoagulation Versus Anticoagulation Alone for Acute Intermediate-High Risk Pulmonary Embolism: Primary Outcomes from the STORM-PE Trial. The S.T.O.R.M.-P.E. trial conducted the first reported randomized controlled trial to evaluate the efficacy and safety of mechanical thrombectomy, specifically computer assisted vacuum thrombectomy, combined with anticoagulation versus anticoagulation alone for acute intermediate-high risk pulmonary embolism. This trial focused on patients with an elevated right ventricular to left ventricular diameter ratio, who are at increased risk of early clinical decompensation and mortality. By rigorously comparing these treatment strategies, the study established foundational data on whether mechanical thrombectomy can effectively relieve acute right ventricular pressure overload and normalize hemodynamics to improve patient outcomes.
Article number two. Prognostic Value of Exercise Right Ventricular-Pulmonary Arterial Coupling in Primary Mitral Regurgitation. This international multicenter cohort study aimed to evaluate the prognostic value of right ventricular-pulmonary arterial coupling in patients with primary mitral regurgitation. The study specifically assessed this coupling by measuring the ratio of tricuspid annular plane systolic excursion to systolic pulmonary artery pressure, both at rest and during exercise. By undertaking this comprehensive evaluation, the research established whether these non-invasive metrics provide a critical tool for risk stratification and improved management of patients with clinically significant primary mitral regurgitation.
Article number three. Efficacy and Safety of Very Low Achieved LDL-Cholesterol in Patients with Prior Ischemic Stroke. This study investigated the efficacy and safety of achieving very low levels of low-density lipoproteins-cholesterol in patients with a history of ischemic stroke. Analyzing data from the F.O.U.R.I.E.R. trial, which studied evolocumab in stable atherosclerotic cardiovascular disease, researchers determined the impact of intensive L.D.L.-C reduction on recurrent stroke and other major adverse cardiovascular events. The findings provide crucial clarity on optimizing lipid management strategies for this high-risk patient population, aiming to improve secondary prevention outcomes following ischemic stroke.
Article number four. Circulating Extracellular Vesicles in the Pathogenesis of Heart Failure in Patients with Chronic Kidney Disease. This cross-sectional study investigated the role of circulating extracellular vesicles in mediating pathological kidney-heart crosstalk, which contributes to heart failure development in patients with chronic kidney disease. Recognizing that cardiovascular disease is a leading cause of death in chronic kidney disease patients and kidney-derived factors are implicated, the research aimed to identify specific humoral risk factors. By elucidating the mechanism through which these vesicles facilitate direct cardiotoxicity, the study provides a foundational understanding to potentially identify novel therapeutic targets for heart failure in this vulnerable population.
Article number five. Prognostic Value of Natriuretic Peptide Levels in Heart Failure With Recovered Ejection Fraction. This retrospective cohort study, spanning from 2009 to 2024 and including 3935 patients, investigated the prognostic value of N-terminal pro-B-type natriuretic peptide levels in individuals with heart failure and recovered left ventricular ejection fraction. The research aimed to determine if N.T.-proB.N.P. measured at the time of left ventricular ejection fraction recovery is an independent predictor of future adverse outcomes. By establishing a robust clinical marker for prognosis in this patient group, the study provides an essential tool for risk stratification and guiding management strategies where such markers are currently lacking.
Thank you for listening. Don’t forget to subscribe.
Keywords
s.P.A.P., evolocumab, left ventricular ejection fraction, anticoagulation, heart failure, L.D.L.-C, mitral regurgitation, T.A.P.S.E., kidney-heart crosstalk, ischemic stroke, recovered ejection fraction, M.A.C.E., extracellular vesicles, recurrent stroke, cardiotoxicity, prognosis, mechanical thrombectomy, chronic kidney disease, pulmonary embolism, right ventricular, intermediate-high risk, N.T.-proB.N.P., right ventricular-pulmonary arterial coupling.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post Prognostic Markers for Recovered E.F. Heart Failure 11/04/25 first appeared on Cardiology Today.
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