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Listen "Survival Odds Slash Heart Failure Trial Bias 11/02/25"
Episode Synopsis
Welcome to Cardiology Today – Recorded November 02, 2025. This episode summarizes 5 key cardiology studies on topics like acute coronary syndrome and A.T.T.R.-C.M.. Key takeaway: Survival Odds Slash Heart Failure Trial Bias.
Article Links:
Article 1: Cannabis use among young adults with acute coronary syndrome: impact on initial presentation and long-term prognosis. (Heart (British Cardiac Society))
Article 2: Left ventricular transthyretin amyloid load and apical sparing in patients with newly confirmed transthyretin amyloid cardiomyopathy. (European journal of heart failure)
Article 3: Survival Odds to Minimize Risk Heterogeneity Bias in Heart Failure Trials: Application to Dapagliflozin. (Circulation. Heart failure)
Article 4: Impact of the Swedish Care Coordination Act on Heart Failure Readmissions and Length of Stay. (Circulation. Heart failure)
Article 5: Timing and Mode of Death Following Treatment of Neonatal Symptomatic Tetralogy of Fallot. (Journal of the American Heart Association)
Full episode page: https://podcast.explainheart.com/podcast/survival-odds-slash-heart-failure-trial-bias-11-02-25/
Featured Articles
Article 1: Cannabis use among young adults with acute coronary syndrome: impact on initial presentation and long-term prognosis.
Journal: Heart (British Cardiac Society)
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41176318
Summary: This retrospective cohort study assessed the association between cannabis use at admission for acute coronary syndrome, or A.C.S., and long-term prognosis in young adults under 45 years old. Patients admitted between 2010 and 2025 who reported current tobacco use were classified based on urinary testing for cannabis upon admission. The research aimed to clarify the cardiovascular impact of cannabis use, which is increasing among young adults, by examining its link to long-term outcomes following an A.C.S. event. This study established a methodology to investigate the clinical implications of cannabis exposure on cardiovascular health in a high-risk population.
Article 2: Left ventricular transthyretin amyloid load and apical sparing in patients with newly confirmed transthyretin amyloid cardiomyopathy.
Journal: European journal of heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41168134
Summary: This study investigated the relationship between echocardiographic apical sparing, a hallmark imaging feature quantified by the R.E.L.A.P.S. pattern, and myocardial transthyretin amyloid load in patients with newly confirmed transthyretin amyloid cardiomyopathy, or A.T.T.R.-C.M. The research aimed to clarify the histopathological and clinical implications of apical sparing in A.T.T.R.-C.M., a condition characterized by transthyretin amyloid deposition, left ventricular hypertrophy, and diastolic dysfunction. By establishing these associations, the study contributes to a more precise understanding of this complex disease and its prognostic indicators.
Article 3: Survival Odds to Minimize Risk Heterogeneity Bias in Heart Failure Trials: Application to Dapagliflozin.
Journal: Circulation. Heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41170566
Summary: This research established a novel methodological approach utilizing “survival odds” to minimize risk heterogeneity bias in heart failure clinical trials. The study addressed the issue where conventional Cox proportional hazards models can underestimate treatment effects due to a disproportionate reduction of event-free patients in control groups over time. By demonstrating the application of this survival odds methodology to dapagliflozin, the research offers a more robust framework for evaluating drug efficacy. This advance ultimately improves the accuracy of clinical trial outcomes for heart failure treatments.
Article 4: Impact of the Swedish Care Coordination Act on Heart Failure Readmissions and Length of Stay.
Journal: Circulation. Heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41170562
Summary: This study investigated the impact of the Swedish nationwide Care Coordination Act, or C.C.A., introduced in January 2018, on outcomes for patients with heart failure. Specifically, the research evaluated the association of this reform with all-cause 30-day hospital readmissions and overall length of stay. By assessing the Act’s goal of improving care coordination and reducing readmissions, the study provides crucial evidence on the effectiveness of national policy interventions in enhancing heart failure management.
Article 5: Timing and Mode of Death Following Treatment of Neonatal Symptomatic Tetralogy of Fallot.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41168949
Summary: This study characterized the timing, specific causes, and associated risk factors of post-procedural death in infants diagnosed with symptomatic tetralogy of Fallot, or s.T.O.F., who underwent early intervention. Focusing on neonates requiring either staged or primary repair strategies for their condition, the research provided crucial definitions of early childhood mortality patterns. By elucidating these factors, the study significantly advances the understanding of risks and potential areas for improved management in this vulnerable pediatric population.
Transcript
Today’s date is November 02, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Cannabis use among young adults with acute coronary syndrome: impact on initial presentation and long-term prognosis. This retrospective cohort study assessed the association between cannabis use at admission for acute coronary syndrome, or A.C.S., and long-term prognosis in young adults under 45 years old. Patients admitted between 2010 and 2025 who reported current tobacco use were classified based on urinary testing for cannabis upon admission. The research aimed to clarify the cardiovascular impact of cannabis use, which is increasing among young adults, by examining its link to long-term outcomes following an A.C.S. event. This study established a methodology to investigate the clinical implications of cannabis exposure on cardiovascular health in a high-risk population.
Article number two. Left ventricular transthyretin amyloid load and apical sparing in patients with newly confirmed transthyretin amyloid cardiomyopathy. This study investigated the relationship between echocardiographic apical sparing, a hallmark imaging feature quantified by the R.E.L.A.P.S. pattern, and myocardial transthyretin amyloid load in patients with newly confirmed transthyretin amyloid cardiomyopathy, or A.T.T.R.-C.M. The research aimed to clarify the histopathological and clinical implications of apical sparing in A.T.T.R.-C.M., a condition characterized by transthyretin amyloid deposition, left ventricular hypertrophy, and diastolic dysfunction. By establishing these associations, the study contributes to a more precise understanding of this complex disease and its prognostic indicators.
Article number three. Survival Odds to Minimize Risk Heterogeneity Bias in Heart Failure Trials: Application to Dapagliflozin. This research established a novel methodological approach utilizing “survival odds” to minimize risk heterogeneity bias in heart failure clinical trials. The study addressed the issue where conventional Cox proportional hazards models can underestimate treatment effects due to a disproportionate reduction of event-free patients in control groups over time. By demonstrating the application of this survival odds methodology to dapagliflozin, the research offers a more robust framework for evaluating drug efficacy. This advance ultimately improves the accuracy of clinical trial outcomes for heart failure treatments.
Article number four. Impact of the Swedish Care Coordination Act on Heart Failure Readmissions and Length of Stay. This study investigated the impact of the Swedish nationwide Care Coordination Act, or C.C.A., introduced in January 2018, on outcomes for patients with heart failure. Specifically, the research evaluated the association of this reform with all-cause 30-day hospital readmissions and overall length of stay. By assessing the Act’s goal of improving care coordination and reducing readmissions, the study provides crucial evidence on the effectiveness of national policy interventions in enhancing heart failure management.
Article number five. Timing and Mode of Death Following Treatment of Neonatal Symptomatic Tetralogy of Fallot. This study characterized the timing, specific causes, and associated risk factors of post-procedural death in infants diagnosed with symptomatic tetralogy of Fallot, or s.T.O.F., who underwent early intervention. Focusing on neonates requiring either staged or primary repair strategies for their condition, the research provided crucial definitions of early childhood mortality patterns. By elucidating these factors, the study significantly advances the understanding of risks and potential areas for improved management in this vulnerable pediatric population.
Thank you for listening. Don’t forget to subscribe.
Keywords
acute coronary syndrome, A.T.T.R.-C.M., Transthyretin amyloid cardiomyopathy, young adults, tobacco use, congenital heart disease, Tetralogy of Fallot, apical sparing, R.E.L.A.P.S. pattern, Care Coordination Act, survival odds, left ventricular hypertrophy, mortality, Cannabis use, clinical trials, Sweden, prognosis, risk heterogeneity bias, Heart failure, length of stay, dapagliflozin, risk factors, neonatal, hospital readmissions.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post Survival Odds Slash Heart Failure Trial Bias 11/02/25 first appeared on Cardiology Today.
Article Links:
Article 1: Cannabis use among young adults with acute coronary syndrome: impact on initial presentation and long-term prognosis. (Heart (British Cardiac Society))
Article 2: Left ventricular transthyretin amyloid load and apical sparing in patients with newly confirmed transthyretin amyloid cardiomyopathy. (European journal of heart failure)
Article 3: Survival Odds to Minimize Risk Heterogeneity Bias in Heart Failure Trials: Application to Dapagliflozin. (Circulation. Heart failure)
Article 4: Impact of the Swedish Care Coordination Act on Heart Failure Readmissions and Length of Stay. (Circulation. Heart failure)
Article 5: Timing and Mode of Death Following Treatment of Neonatal Symptomatic Tetralogy of Fallot. (Journal of the American Heart Association)
Full episode page: https://podcast.explainheart.com/podcast/survival-odds-slash-heart-failure-trial-bias-11-02-25/
Featured Articles
Article 1: Cannabis use among young adults with acute coronary syndrome: impact on initial presentation and long-term prognosis.
Journal: Heart (British Cardiac Society)
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41176318
Summary: This retrospective cohort study assessed the association between cannabis use at admission for acute coronary syndrome, or A.C.S., and long-term prognosis in young adults under 45 years old. Patients admitted between 2010 and 2025 who reported current tobacco use were classified based on urinary testing for cannabis upon admission. The research aimed to clarify the cardiovascular impact of cannabis use, which is increasing among young adults, by examining its link to long-term outcomes following an A.C.S. event. This study established a methodology to investigate the clinical implications of cannabis exposure on cardiovascular health in a high-risk population.
Article 2: Left ventricular transthyretin amyloid load and apical sparing in patients with newly confirmed transthyretin amyloid cardiomyopathy.
Journal: European journal of heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41168134
Summary: This study investigated the relationship between echocardiographic apical sparing, a hallmark imaging feature quantified by the R.E.L.A.P.S. pattern, and myocardial transthyretin amyloid load in patients with newly confirmed transthyretin amyloid cardiomyopathy, or A.T.T.R.-C.M. The research aimed to clarify the histopathological and clinical implications of apical sparing in A.T.T.R.-C.M., a condition characterized by transthyretin amyloid deposition, left ventricular hypertrophy, and diastolic dysfunction. By establishing these associations, the study contributes to a more precise understanding of this complex disease and its prognostic indicators.
Article 3: Survival Odds to Minimize Risk Heterogeneity Bias in Heart Failure Trials: Application to Dapagliflozin.
Journal: Circulation. Heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41170566
Summary: This research established a novel methodological approach utilizing “survival odds” to minimize risk heterogeneity bias in heart failure clinical trials. The study addressed the issue where conventional Cox proportional hazards models can underestimate treatment effects due to a disproportionate reduction of event-free patients in control groups over time. By demonstrating the application of this survival odds methodology to dapagliflozin, the research offers a more robust framework for evaluating drug efficacy. This advance ultimately improves the accuracy of clinical trial outcomes for heart failure treatments.
Article 4: Impact of the Swedish Care Coordination Act on Heart Failure Readmissions and Length of Stay.
Journal: Circulation. Heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41170562
Summary: This study investigated the impact of the Swedish nationwide Care Coordination Act, or C.C.A., introduced in January 2018, on outcomes for patients with heart failure. Specifically, the research evaluated the association of this reform with all-cause 30-day hospital readmissions and overall length of stay. By assessing the Act’s goal of improving care coordination and reducing readmissions, the study provides crucial evidence on the effectiveness of national policy interventions in enhancing heart failure management.
Article 5: Timing and Mode of Death Following Treatment of Neonatal Symptomatic Tetralogy of Fallot.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41168949
Summary: This study characterized the timing, specific causes, and associated risk factors of post-procedural death in infants diagnosed with symptomatic tetralogy of Fallot, or s.T.O.F., who underwent early intervention. Focusing on neonates requiring either staged or primary repair strategies for their condition, the research provided crucial definitions of early childhood mortality patterns. By elucidating these factors, the study significantly advances the understanding of risks and potential areas for improved management in this vulnerable pediatric population.
Transcript
Today’s date is November 02, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Cannabis use among young adults with acute coronary syndrome: impact on initial presentation and long-term prognosis. This retrospective cohort study assessed the association between cannabis use at admission for acute coronary syndrome, or A.C.S., and long-term prognosis in young adults under 45 years old. Patients admitted between 2010 and 2025 who reported current tobacco use were classified based on urinary testing for cannabis upon admission. The research aimed to clarify the cardiovascular impact of cannabis use, which is increasing among young adults, by examining its link to long-term outcomes following an A.C.S. event. This study established a methodology to investigate the clinical implications of cannabis exposure on cardiovascular health in a high-risk population.
Article number two. Left ventricular transthyretin amyloid load and apical sparing in patients with newly confirmed transthyretin amyloid cardiomyopathy. This study investigated the relationship between echocardiographic apical sparing, a hallmark imaging feature quantified by the R.E.L.A.P.S. pattern, and myocardial transthyretin amyloid load in patients with newly confirmed transthyretin amyloid cardiomyopathy, or A.T.T.R.-C.M. The research aimed to clarify the histopathological and clinical implications of apical sparing in A.T.T.R.-C.M., a condition characterized by transthyretin amyloid deposition, left ventricular hypertrophy, and diastolic dysfunction. By establishing these associations, the study contributes to a more precise understanding of this complex disease and its prognostic indicators.
Article number three. Survival Odds to Minimize Risk Heterogeneity Bias in Heart Failure Trials: Application to Dapagliflozin. This research established a novel methodological approach utilizing “survival odds” to minimize risk heterogeneity bias in heart failure clinical trials. The study addressed the issue where conventional Cox proportional hazards models can underestimate treatment effects due to a disproportionate reduction of event-free patients in control groups over time. By demonstrating the application of this survival odds methodology to dapagliflozin, the research offers a more robust framework for evaluating drug efficacy. This advance ultimately improves the accuracy of clinical trial outcomes for heart failure treatments.
Article number four. Impact of the Swedish Care Coordination Act on Heart Failure Readmissions and Length of Stay. This study investigated the impact of the Swedish nationwide Care Coordination Act, or C.C.A., introduced in January 2018, on outcomes for patients with heart failure. Specifically, the research evaluated the association of this reform with all-cause 30-day hospital readmissions and overall length of stay. By assessing the Act’s goal of improving care coordination and reducing readmissions, the study provides crucial evidence on the effectiveness of national policy interventions in enhancing heart failure management.
Article number five. Timing and Mode of Death Following Treatment of Neonatal Symptomatic Tetralogy of Fallot. This study characterized the timing, specific causes, and associated risk factors of post-procedural death in infants diagnosed with symptomatic tetralogy of Fallot, or s.T.O.F., who underwent early intervention. Focusing on neonates requiring either staged or primary repair strategies for their condition, the research provided crucial definitions of early childhood mortality patterns. By elucidating these factors, the study significantly advances the understanding of risks and potential areas for improved management in this vulnerable pediatric population.
Thank you for listening. Don’t forget to subscribe.
Keywords
acute coronary syndrome, A.T.T.R.-C.M., Transthyretin amyloid cardiomyopathy, young adults, tobacco use, congenital heart disease, Tetralogy of Fallot, apical sparing, R.E.L.A.P.S. pattern, Care Coordination Act, survival odds, left ventricular hypertrophy, mortality, Cannabis use, clinical trials, Sweden, prognosis, risk heterogeneity bias, Heart failure, length of stay, dapagliflozin, risk factors, neonatal, hospital readmissions.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post Survival Odds Slash Heart Failure Trial Bias 11/02/25 first appeared on Cardiology Today.
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