Unlocking Yeast's Secretory Potential: Innovations in MFa Signal Sequences

BiotecInsights
06/10/2025 9 min

Listen "Unlocking Yeast's Secretory Potential: Innovations in MFa Signal Sequences"

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Episode Synopsis

The MFa signal sequence is key for recombinant protein secretion in yeast. This review details its evolution, processing, and challenges like missorting and aggregation. Innovations include optimized MFa variants, hybrid sequences, and cell engineering, significantly boosting protein yield and quality for biotechnological and therapeutic applications.

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