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Listen "The FLO8 Breakthrough: A New Era for Methanol-Free Protein Production in Komagataella phaffii"
Episode Synopsis
Flo8 knockout in Komagataella phaffii prevents pseudohyphal growth and reduces adherence. This study reveals it significantly elevates glucose-regulatable promoter activity, boosting recombinant protein yields up to 7-fold. This new host strain offers higher productivity per gene copy and improved process robustness for methanol-free bioproduction.Original Publication
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