Decoding CHO Cell Survival: CRISPR Reveals Essential Genomic "Dark Matter"

BiotecInsights
08/10/2025 7 min

Listen "Decoding CHO Cell Survival: CRISPR Reveals Essential Genomic "Dark Matter""

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Episode Synopsis

We performed a genome-scale CRISPR screen in CHO cells using paired guide RNAs, identifying 427 essential genomic regions, including unannotated "dark matter." Deleting these regions impairs cell survival, revealing critical regulatory functions and enabling advanced bioprocess engineering.

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