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Listen "S1E5 - Seeing composite outcomes CLEAR-ly: Bempedoic acid versus placebo for preventing Major Adverse Cardiovascular Outcomes"
Episode Synopsis
08Welcome to What's it Worth! Join your hosts, Dr. Diana Langworthy, Nathan Uk, and Garrison Griest as we walk you through composite outcomes with the CLEAR trial - a comparison of bempedoic acid versus placebo for preventing major adverse cardiovascular events (MACE) in patients who cannot tolerate statin therapy. We're joined by Dr. Chrystian Pereira, PharmD, BCACP, an ambulatory care pharmacist at the Smiley's Family Medicine Clinic in South Minneapolis, MN. Key Points Statins play a key role in prevention of major cardiovascular events (MACE), yet not all patients tolerate them Bempedoic acid may have a place in therapy to prevent MACE for patients who cannot tolerate statins Composite outcomes involve > 1 outcome and they should be of similar clinical severity Learning your POEMs and DOEs of a trial help you critique evidence that matters --> Tune in to learn more about what POEMs and DOEs are! References [EPISODE TRIAL] Nissen SE, Lincoff AM, Brennan D, et al. Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients. NEJM 2023; DOI: 10.1056/NEJMoa2215024. Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of blood cholesterol: a report of the American College of Cardiology/American Heart Association Task Force on clinical practice guidelines. Circulation 2019;139(25):e1082-e1143. Bytyci I, Penson PE, Mikhailidis DP, et al. Prevalence of statin intolerance: a meta-analysis. Eur Heart J 2022;43:3213-23. Shaikh A, Ochani RK, Khan MS, et al. Contribution of individual components to composite end points in contemporary cardiovascular randomized controlled trials. Am Heart J 2020;230:71-81. Contact Information Podcast email: [email protected] Host Information Dr. Diana R. Langworthy, PharmD, BCPS Clinical Associate Professor, University of Minnesota College of Pharmacy Clinical Pharmacist - Inpatient Internal Medicine, M Health Fairview East Bank Hospital Guest Host Information Garrison Griest, Student Pharmacist, Class of 2025 University of Minnesota Nathan Uk, Student Pharmacist, Class of 2025 University of Minnesota Guest Expert Dr. Chrystian Pereira, PharmD, BCACP, Associate Professor, University of Minnesota College of Pharmacy
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