In this episode of the College of Glycation podcast, Dr. Paul Reynolds—Professor of Cell Biology and Biomedical Scientist—uncovers how a single biochemical process, glycation, can set off a chain reaction leading to metabolic syndrome. From stiffened arteries and distorted cholesterol to insulin resistance and mitochondrial damage, advanced glycation end-products (AGEs) quietly but powerfully drive the cluster of conditions that raise the risk of heart disease, stroke, and type 2 diabetes.Drawing on decades of research, Dr. Reynolds explains how AGEs form both inside the body and on our plates, thanks to high-heat cooking, processed foods, and sugar-heavy diets. You’ll learn how these “molecular wrecking balls” fuel inflammation, oxidative stress, and hormonal imbalance—and more importantly, how to interrupt the cycle. Packed with practical tips, this episode empowers you to make small, science-backed changes in your diet, lifestyle, and cooking habits to protect your metabolic health and longevity.

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