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Listen "TGF-beta Blockade Prevents Heart Scarring? 09/20/25"
Episode Synopsis
Welcome to Cardiology Today – Recorded September 20, 2025. This episode summarizes 5 key cardiology studies on topics like non-ST segment elevation acute coronary syndrome and machine learning. Key takeaway: TGF-beta Blockade Prevents Heart Scarring?.
Article Links:
Article 1: Fibroblast-Specific Loss of TGF-β Signaling Mediates Lipomatous Metaplasia in the Infarcted Heart. (Circulation)
Article 2: Role of A2AR-D2R Dimerization and D2R-Biased Signaling in PDE10A-Mediated Cardiac Hypertrophy. (Circulation)
Article 3: Early antiplatelet treatment for minor stroke following thrombolysis: the EAST trial. (European heart journal)
Article 4: Postprocedural parenteral anticoagulation in patients with non-ST segment elevation acute coronary syndromes. (The Canadian journal of cardiology)
Article 5: Machine Learning Reveals How Depression Influences Chest Pain Localization and Its Predictive Value for Coronary Artery Disease. (The Canadian journal of cardiology)
Full episode page: https://podcast.explainheart.com/podcast/tgf-beta-blockade-prevents-heart-scarring-09-20-25/
Featured Articles
Article 1: Fibroblast-Specific Loss of TGF-β Signaling Mediates Lipomatous Metaplasia in the Infarcted Heart.
Journal: Circulation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40970279
Summary: This study in mice revealed that fibroblast-specific disruption of transforming growth factor beta signaling leads to the conversion of fibroblasts to adipocytes, causing fatty infiltration in the infarcted heart. The findings suggest that blocking this pathway could potentially reduce adverse remodeling and arrhythmias post myocardial infarction. This provides a novel therapeutic target to prevent lipomatous metaplasia.
Article 2: Role of A2AR-D2R Dimerization and D2R-Biased Signaling in PDE10A-Mediated Cardiac Hypertrophy.
Journal: Circulation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40970278
Summary: This research demonstrates that phosphodiesterase 10A contributes to pathological cardiomyocyte hypertrophy through A2AR-D2R dimerization and D2R-biased signaling. Inhibiting phosphodiesterase 10A may be a potential therapeutic target for preventing or reversing cardiac hypertrophy. The study clarifies specific signaling pathways modulated by phosphodiesterase 10A.
Article 3: Early antiplatelet treatment for minor stroke following thrombolysis: the EAST trial.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40973702
Summary: The EAST trial, a randomized controlled trial, evaluated early antiplatelet therapy versus placebo after intravenous thrombolysis in patients with minor stroke. The study found early antiplatelet treatment was safe and effective compared to delayed antiplatelet treatment, with no significant increase in hemorrhagic transformation. These results support earlier initiation of antiplatelet agents in select stroke patients.
Article 4: Postprocedural parenteral anticoagulation in patients with non-ST segment elevation acute coronary syndromes.
Journal: The Canadian journal of cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40972897
Summary: This study investigated the association between post procedural parenteral anticoagulation and clinical outcomes in patients with non-ST segment elevation acute coronary syndrome following percutaneous coronary intervention. The findings showed post procedural anticoagulation was not associated with improved outcomes. This reinforces current guideline recommendations against routine post percutaneous coronary intervention anticoagulation in this population.
Article 5: Machine Learning Reveals How Depression Influences Chest Pain Localization and Its Predictive Value for Coronary Artery Disease.
Journal: The Canadian journal of cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40972896
Summary: This study used machine learning to analyze the relationship between depression and chest pain localization in predicting coronary artery disease. The results demonstrated that depression influences chest pain characteristics, affecting its predictive value for coronary artery disease. Understanding this relationship may improve cardiovascular risk assessment in patients with depression.
Transcript
Today’s date is September 20, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Fibroblast-Specific Loss of Transforming Growth Factor Beta Signaling Mediates Lipomatous Metaplasia in the Infarcted Heart. This study in mice revealed that fibroblast-specific disruption of transforming growth factor beta signaling leads to the conversion of fibroblasts to adipocytes, causing fatty infiltration in the infarcted heart. The findings suggest that blocking this pathway could potentially reduce adverse remodeling and arrhythmias post myocardial infarction. This provides a novel therapeutic target to prevent lipomatous metaplasia.
Article number two. Role of A2AR-D2R Dimerization and D2R-Biased Signaling in Phosphodiesterase 10A-Mediated Cardiac Hypertrophy. This research demonstrates that phosphodiesterase 10A contributes to pathological cardiomyocyte hypertrophy through A2AR-D2R dimerization and D2R-biased signaling. Inhibiting phosphodiesterase 10A may be a potential therapeutic target for preventing or reversing cardiac hypertrophy. The study clarifies specific signaling pathways modulated by phosphodiesterase 10A.
Article number three. Early antiplatelet treatment for minor stroke following thrombolysis: the EAST trial. The EAST trial, a randomized controlled trial, evaluated early antiplatelet therapy versus placebo after intravenous thrombolysis in patients with minor stroke. The study found early antiplatelet treatment was safe and effective compared to delayed antiplatelet treatment, with no significant increase in hemorrhagic transformation. These results support earlier initiation of antiplatelet agents in select stroke patients.
Article number four. Postprocedural parenteral anticoagulation in patients with non-ST segment elevation acute coronary syndromes. This study investigated the association between post procedural parenteral anticoagulation and clinical outcomes in patients with non-ST segment elevation acute coronary syndrome following percutaneous coronary intervention. The findings showed post procedural anticoagulation was not associated with improved outcomes. This reinforces current guideline recommendations against routine post percutaneous coronary intervention anticoagulation in this population.
Article number five. Machine Learning Reveals How Depression Influences Chest Pain Localization and Its Predictive Value for Coronary Artery Disease. This study used machine learning to analyze the relationship between depression and chest pain localization in predicting coronary artery disease. The results demonstrated that depression influences chest pain characteristics, affecting its predictive value for coronary artery disease. Understanding this relationship may improve cardiovascular risk assessment in patients with depression.
Thank you for listening. Don’t forget to subscribe.
Keywords
non-ST segment elevation acute coronary syndrome, machine learning, antiplatelet therapy, chest pain, transforming growth factor beta, dilated cardiomyopathy, clinical outcomes, parenteral anticoagulation, depression, coronary artery disease, phosphodiesterase 10A, thrombolysis, ischaemic stroke, haemorrhagic transformation, fibroblast, anticoagulation, stroke, myocardial infarction, adipocyte, A2AR-D2R dimerization, lipomatous metaplasia, percutaneous coronary intervention, cardiovascular risk, cardiomyocyte, cardiac hypertrophy.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post TGF-beta Blockade Prevents Heart Scarring? 09/20/25 first appeared on Cardiology Today.
Article Links:
Article 1: Fibroblast-Specific Loss of TGF-β Signaling Mediates Lipomatous Metaplasia in the Infarcted Heart. (Circulation)
Article 2: Role of A2AR-D2R Dimerization and D2R-Biased Signaling in PDE10A-Mediated Cardiac Hypertrophy. (Circulation)
Article 3: Early antiplatelet treatment for minor stroke following thrombolysis: the EAST trial. (European heart journal)
Article 4: Postprocedural parenteral anticoagulation in patients with non-ST segment elevation acute coronary syndromes. (The Canadian journal of cardiology)
Article 5: Machine Learning Reveals How Depression Influences Chest Pain Localization and Its Predictive Value for Coronary Artery Disease. (The Canadian journal of cardiology)
Full episode page: https://podcast.explainheart.com/podcast/tgf-beta-blockade-prevents-heart-scarring-09-20-25/
Featured Articles
Article 1: Fibroblast-Specific Loss of TGF-β Signaling Mediates Lipomatous Metaplasia in the Infarcted Heart.
Journal: Circulation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40970279
Summary: This study in mice revealed that fibroblast-specific disruption of transforming growth factor beta signaling leads to the conversion of fibroblasts to adipocytes, causing fatty infiltration in the infarcted heart. The findings suggest that blocking this pathway could potentially reduce adverse remodeling and arrhythmias post myocardial infarction. This provides a novel therapeutic target to prevent lipomatous metaplasia.
Article 2: Role of A2AR-D2R Dimerization and D2R-Biased Signaling in PDE10A-Mediated Cardiac Hypertrophy.
Journal: Circulation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40970278
Summary: This research demonstrates that phosphodiesterase 10A contributes to pathological cardiomyocyte hypertrophy through A2AR-D2R dimerization and D2R-biased signaling. Inhibiting phosphodiesterase 10A may be a potential therapeutic target for preventing or reversing cardiac hypertrophy. The study clarifies specific signaling pathways modulated by phosphodiesterase 10A.
Article 3: Early antiplatelet treatment for minor stroke following thrombolysis: the EAST trial.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40973702
Summary: The EAST trial, a randomized controlled trial, evaluated early antiplatelet therapy versus placebo after intravenous thrombolysis in patients with minor stroke. The study found early antiplatelet treatment was safe and effective compared to delayed antiplatelet treatment, with no significant increase in hemorrhagic transformation. These results support earlier initiation of antiplatelet agents in select stroke patients.
Article 4: Postprocedural parenteral anticoagulation in patients with non-ST segment elevation acute coronary syndromes.
Journal: The Canadian journal of cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40972897
Summary: This study investigated the association between post procedural parenteral anticoagulation and clinical outcomes in patients with non-ST segment elevation acute coronary syndrome following percutaneous coronary intervention. The findings showed post procedural anticoagulation was not associated with improved outcomes. This reinforces current guideline recommendations against routine post percutaneous coronary intervention anticoagulation in this population.
Article 5: Machine Learning Reveals How Depression Influences Chest Pain Localization and Its Predictive Value for Coronary Artery Disease.
Journal: The Canadian journal of cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40972896
Summary: This study used machine learning to analyze the relationship between depression and chest pain localization in predicting coronary artery disease. The results demonstrated that depression influences chest pain characteristics, affecting its predictive value for coronary artery disease. Understanding this relationship may improve cardiovascular risk assessment in patients with depression.
Transcript
Today’s date is September 20, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Fibroblast-Specific Loss of Transforming Growth Factor Beta Signaling Mediates Lipomatous Metaplasia in the Infarcted Heart. This study in mice revealed that fibroblast-specific disruption of transforming growth factor beta signaling leads to the conversion of fibroblasts to adipocytes, causing fatty infiltration in the infarcted heart. The findings suggest that blocking this pathway could potentially reduce adverse remodeling and arrhythmias post myocardial infarction. This provides a novel therapeutic target to prevent lipomatous metaplasia.
Article number two. Role of A2AR-D2R Dimerization and D2R-Biased Signaling in Phosphodiesterase 10A-Mediated Cardiac Hypertrophy. This research demonstrates that phosphodiesterase 10A contributes to pathological cardiomyocyte hypertrophy through A2AR-D2R dimerization and D2R-biased signaling. Inhibiting phosphodiesterase 10A may be a potential therapeutic target for preventing or reversing cardiac hypertrophy. The study clarifies specific signaling pathways modulated by phosphodiesterase 10A.
Article number three. Early antiplatelet treatment for minor stroke following thrombolysis: the EAST trial. The EAST trial, a randomized controlled trial, evaluated early antiplatelet therapy versus placebo after intravenous thrombolysis in patients with minor stroke. The study found early antiplatelet treatment was safe and effective compared to delayed antiplatelet treatment, with no significant increase in hemorrhagic transformation. These results support earlier initiation of antiplatelet agents in select stroke patients.
Article number four. Postprocedural parenteral anticoagulation in patients with non-ST segment elevation acute coronary syndromes. This study investigated the association between post procedural parenteral anticoagulation and clinical outcomes in patients with non-ST segment elevation acute coronary syndrome following percutaneous coronary intervention. The findings showed post procedural anticoagulation was not associated with improved outcomes. This reinforces current guideline recommendations against routine post percutaneous coronary intervention anticoagulation in this population.
Article number five. Machine Learning Reveals How Depression Influences Chest Pain Localization and Its Predictive Value for Coronary Artery Disease. This study used machine learning to analyze the relationship between depression and chest pain localization in predicting coronary artery disease. The results demonstrated that depression influences chest pain characteristics, affecting its predictive value for coronary artery disease. Understanding this relationship may improve cardiovascular risk assessment in patients with depression.
Thank you for listening. Don’t forget to subscribe.
Keywords
non-ST segment elevation acute coronary syndrome, machine learning, antiplatelet therapy, chest pain, transforming growth factor beta, dilated cardiomyopathy, clinical outcomes, parenteral anticoagulation, depression, coronary artery disease, phosphodiesterase 10A, thrombolysis, ischaemic stroke, haemorrhagic transformation, fibroblast, anticoagulation, stroke, myocardial infarction, adipocyte, A2AR-D2R dimerization, lipomatous metaplasia, percutaneous coronary intervention, cardiovascular risk, cardiomyocyte, cardiac hypertrophy.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post TGF-beta Blockade Prevents Heart Scarring? 09/20/25 first appeared on Cardiology Today.
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