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Listen "PREVENT Equations Refine Blood Pressure Control. 10/28/25"
Episode Synopsis
Welcome to Cardiology Today – Recorded October 28, 2025. This episode summarizes 5 key cardiology studies on topics like PARTNER 3 trial and ESPRIT trial. Key takeaway: PREVENT Equations Refine Blood Pressure Control..
Article Links:
Article 1: Transcatheter or Surgical Aortic-Valve Replacement in Low-Risk Patients at 7 Years. (The New England journal of medicine)
Article 2: Using PREVENT Equations to Compare Intensive vs Standard Systolic Blood Pressure Control for Primary Prevention in SPRINT. (Journal of the American College of Cardiology)
Article 3: Effect of Intensive Blood Pressure Control on Stroke: A Prespecified Secondary Analysis of the ESPRIT Trial. (Journal of the American College of Cardiology)
Article 4: Clinical Practice of Surgical Treatment for Left-Sided Infective Endocarditis: Nationwide Data from the NIDUS Registry. (Circulation)
Article 5: Long-Term Outcomes of Early Surgery Versus Conventional Treatment for Asymptomatic Severe Mitral Regurgitation: A Propensity Analysis. (Circulation)
Full episode page: https://podcast.explainheart.com/podcast/prevent-equations-refine-blood-pressure-control-10-28-25/
Featured Articles
Article 1: Transcatheter or Surgical Aortic-Valve Replacement in Low-Risk Patients at 7 Years.
Journal: The New England journal of medicine
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41144631
Summary: This study from the PARTNER 3 trial aimed to provide longer-term clinical outcomes and valve durability assessments up to 7 years for low-risk patients with severe, symptomatic aortic stenosis. Patients were randomly assigned in a 1:1 ratio to undergo either transfemoral transcatheter aortic-valve replacement (T.A.V.R.) or surgical aortic-valve replacement. Prior 5-year data from this trial demonstrated similar outcomes between the two procedures. The research underscores the importance of continued long-term evaluation for valve durability and clinical effectiveness in these patients.
Article 2: Using PREVENT Equations to Compare Intensive vs Standard Systolic Blood Pressure Control for Primary Prevention in SPRINT.
Journal: Journal of the American College of Cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41125318
Summary: This secondary analysis of the SPRINT trial aimed to quantify the relative and absolute benefits and harms of intensive versus standard systolic blood pressure (S.B.P.) treatment using the new Predicting Risk of Cardiovascular Disease Events (PREVENT) equations. The PREVENT equations provide enhanced risk stratification by integrating estimated glomerular filtration rate, omitting race, and encompassing total cardiovascular disease events including heart failure. This research established a method for more precisely comparing intensive versus standard S.B.P. control by varying cardiovascular risk levels. The study demonstrates the utility of the PREVENT equations in refining primary prevention strategies for cardiovascular disease.
Article 3: Effect of Intensive Blood Pressure Control on Stroke: A Prespecified Secondary Analysis of the ESPRIT Trial.
Journal: Journal of the American College of Cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40864014
Summary: This prespecified secondary analysis of the ESPRIT trial evaluated the effects of intensive blood pressure control on stroke outcomes. Hypertensive patients with elevated cardiovascular risk were randomized to either intensive treatment, targeting systolic blood pressure (S.B.P.) below 120 millimeters of mercury, or standard treatment, aiming for S.B.P. below 140 millimeters of mercury. The study investigated the comparative impact of these two blood pressure management strategies on preventing stroke. This research highlights the critical role of S.B.P. reduction in stroke prevention, providing a focused comparison of intensive versus standard therapeutic approaches.
Article 4: Clinical Practice of Surgical Treatment for Left-Sided Infective Endocarditis: Nationwide Data from the NIDUS Registry.
Journal: Circulation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40836922
Summary: This observational cohort study utilized nationwide data from the NIDUS Registry to describe the clinical practice of surgical treatment for left-sided infective endocarditis (I.E.). The research specifically aimed to detail the utilization of surgery based on established indications and to assess associated mortality rates in this patient population. By examining a broad national cohort, this study overcomes limitations of prior research from selected tertiary centers, providing a more representative picture of real-world surgical approaches. This comprehensive analysis establishes a valuable benchmark for understanding current surgical interventions and outcomes in left-sided I.E.
Article 5: Long-Term Outcomes of Early Surgery Versus Conventional Treatment for Asymptomatic Severe Mitral Regurgitation: A Propensity Analysis.
Journal: Circulation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40799133
Summary: This observational study employed propensity analysis to compare long-term outcomes of early surgical intervention versus conventional treatment for asymptomatic patients with severe mitral regurgitation. Researchers enrolled 1063 consecutive asymptomatic patients exhibiting severe degenerative mitral regurgitation and preserved left ventricular (L.V.) function, with prospective follow-up from 1996 to 2016. The study provides crucial data to address the clinical controversy surrounding the optimal timing of surgery in this specific patient group. This comprehensive analysis helps to establish the long-term impact of different management strategies for asymptomatic severe mitral regurgitation.
Transcript
Today’s date is October 28, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Transcatheter or Surgical Aortic-Valve Replacement in Low-Risk Patients at 7 Years. This study from the PARTNER 3 trial aimed to provide longer-term clinical outcomes and valve durability assessments up to 7 years for low-risk patients with severe, symptomatic aortic stenosis. Patients were randomly assigned in a 1:1 ratio to undergo either transfemoral transcatheter aortic-valve replacement (T.A.V.R.) or surgical aortic-valve replacement. Prior 5-year data from this trial demonstrated similar outcomes between the two procedures. The research underscores the importance of continued long-term evaluation for valve durability and clinical effectiveness in these patients.
Article number two. Using PREVENT Equations to Compare Intensive vs Standard Systolic Blood Pressure Control for Primary Prevention in SPRINT. This secondary analysis of the SPRINT trial aimed to quantify the relative and absolute benefits and harms of intensive versus standard systolic blood pressure (S.B.P.) treatment using the new Predicting Risk of Cardiovascular Disease Events (PREVENT) equations. The PREVENT equations provide enhanced risk stratification by integrating estimated glomerular filtration rate, omitting race, and encompassing total cardiovascular disease events including heart failure. This research established a method for more precisely comparing intensive versus standard S.B.P. control by varying cardiovascular risk levels. The study demonstrates the utility of the PREVENT equations in refining primary prevention strategies for cardiovascular disease.
Article number three. Effect of Intensive Blood Pressure Control on Stroke: A Prespecified Secondary Analysis of the ESPRIT Trial. This prespecified secondary analysis of the ESPRIT trial evaluated the effects of intensive blood pressure control on stroke outcomes. Hypertensive patients with elevated cardiovascular risk were randomized to either intensive treatment, targeting systolic blood pressure (S.B.P.) below 120 millimeters of mercury, or standard treatment, aiming for S.B.P. below 140 millimeters of mercury. The study investigated the comparative impact of these two blood pressure management strategies on preventing stroke. This research highlights the critical role of S.B.P. reduction in stroke prevention, providing a focused comparison of intensive versus standard therapeutic approaches.
Article number four. Clinical Practice of Surgical Treatment for Left-Sided Infective Endocarditis: Nationwide Data from the NIDUS Registry. This observational cohort study utilized nationwide data from the NIDUS Registry to describe the clinical practice of surgical treatment for left-sided infective endocarditis (I.E.). The research specifically aimed to detail the utilization of surgery based on established indications and to assess associated mortality rates in this patient population. By examining a broad national cohort, this study overcomes limitations of prior research from selected tertiary centers, providing a more representative picture of real-world surgical approaches. This comprehensive analysis establishes a valuable benchmark for understanding current surgical interventions and outcomes in left-sided I.E.
Article number five. Long-Term Outcomes of Early Surgery Versus Conventional Treatment for Asymptomatic Severe Mitral Regurgitation: A Propensity Analysis. This observational study employed propensity analysis to compare long-term outcomes of early surgical intervention versus conventional treatment for asymptomatic patients with severe mitral regurgitation. Researchers enrolled 1063 consecutive asymptomatic patients exhibiting severe degenerative mitral regurgitation and preserved left ventricular (L.V.) function, with prospective follow-up from 1996 to 2016. The study provides crucial data to address the clinical controversy surrounding the optimal timing of surgery in this specific patient group. This comprehensive analysis helps to establish the long-term impact of different management strategies for asymptomatic severe mitral regurgitation.
Thank you for listening. Don’t forget to subscribe.
Keywords
PARTNER 3 trial, ESPRIT trial, conventional treatment, stroke prevention, mitral regurgitation, valve durability, early surgery, aortic stenosis, hypertension, systolic blood pressure, intensive blood pressure control, SPRINT trial, surgical aortic-valve replacement, cardiovascular disease primary prevention, mortality, left-sided endocarditis, infective endocarditis, surgical treatment, NIDUS Registry, PREVENT equations, asymptomatic mitral regurgitation, transcatheter aortic-valve replacement, left ventricular function.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post PREVENT Equations Refine Blood Pressure Control. 10/28/25 first appeared on Cardiology Today.
Article Links:
Article 1: Transcatheter or Surgical Aortic-Valve Replacement in Low-Risk Patients at 7 Years. (The New England journal of medicine)
Article 2: Using PREVENT Equations to Compare Intensive vs Standard Systolic Blood Pressure Control for Primary Prevention in SPRINT. (Journal of the American College of Cardiology)
Article 3: Effect of Intensive Blood Pressure Control on Stroke: A Prespecified Secondary Analysis of the ESPRIT Trial. (Journal of the American College of Cardiology)
Article 4: Clinical Practice of Surgical Treatment for Left-Sided Infective Endocarditis: Nationwide Data from the NIDUS Registry. (Circulation)
Article 5: Long-Term Outcomes of Early Surgery Versus Conventional Treatment for Asymptomatic Severe Mitral Regurgitation: A Propensity Analysis. (Circulation)
Full episode page: https://podcast.explainheart.com/podcast/prevent-equations-refine-blood-pressure-control-10-28-25/
Featured Articles
Article 1: Transcatheter or Surgical Aortic-Valve Replacement in Low-Risk Patients at 7 Years.
Journal: The New England journal of medicine
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41144631
Summary: This study from the PARTNER 3 trial aimed to provide longer-term clinical outcomes and valve durability assessments up to 7 years for low-risk patients with severe, symptomatic aortic stenosis. Patients were randomly assigned in a 1:1 ratio to undergo either transfemoral transcatheter aortic-valve replacement (T.A.V.R.) or surgical aortic-valve replacement. Prior 5-year data from this trial demonstrated similar outcomes between the two procedures. The research underscores the importance of continued long-term evaluation for valve durability and clinical effectiveness in these patients.
Article 2: Using PREVENT Equations to Compare Intensive vs Standard Systolic Blood Pressure Control for Primary Prevention in SPRINT.
Journal: Journal of the American College of Cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41125318
Summary: This secondary analysis of the SPRINT trial aimed to quantify the relative and absolute benefits and harms of intensive versus standard systolic blood pressure (S.B.P.) treatment using the new Predicting Risk of Cardiovascular Disease Events (PREVENT) equations. The PREVENT equations provide enhanced risk stratification by integrating estimated glomerular filtration rate, omitting race, and encompassing total cardiovascular disease events including heart failure. This research established a method for more precisely comparing intensive versus standard S.B.P. control by varying cardiovascular risk levels. The study demonstrates the utility of the PREVENT equations in refining primary prevention strategies for cardiovascular disease.
Article 3: Effect of Intensive Blood Pressure Control on Stroke: A Prespecified Secondary Analysis of the ESPRIT Trial.
Journal: Journal of the American College of Cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40864014
Summary: This prespecified secondary analysis of the ESPRIT trial evaluated the effects of intensive blood pressure control on stroke outcomes. Hypertensive patients with elevated cardiovascular risk were randomized to either intensive treatment, targeting systolic blood pressure (S.B.P.) below 120 millimeters of mercury, or standard treatment, aiming for S.B.P. below 140 millimeters of mercury. The study investigated the comparative impact of these two blood pressure management strategies on preventing stroke. This research highlights the critical role of S.B.P. reduction in stroke prevention, providing a focused comparison of intensive versus standard therapeutic approaches.
Article 4: Clinical Practice of Surgical Treatment for Left-Sided Infective Endocarditis: Nationwide Data from the NIDUS Registry.
Journal: Circulation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40836922
Summary: This observational cohort study utilized nationwide data from the NIDUS Registry to describe the clinical practice of surgical treatment for left-sided infective endocarditis (I.E.). The research specifically aimed to detail the utilization of surgery based on established indications and to assess associated mortality rates in this patient population. By examining a broad national cohort, this study overcomes limitations of prior research from selected tertiary centers, providing a more representative picture of real-world surgical approaches. This comprehensive analysis establishes a valuable benchmark for understanding current surgical interventions and outcomes in left-sided I.E.
Article 5: Long-Term Outcomes of Early Surgery Versus Conventional Treatment for Asymptomatic Severe Mitral Regurgitation: A Propensity Analysis.
Journal: Circulation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40799133
Summary: This observational study employed propensity analysis to compare long-term outcomes of early surgical intervention versus conventional treatment for asymptomatic patients with severe mitral regurgitation. Researchers enrolled 1063 consecutive asymptomatic patients exhibiting severe degenerative mitral regurgitation and preserved left ventricular (L.V.) function, with prospective follow-up from 1996 to 2016. The study provides crucial data to address the clinical controversy surrounding the optimal timing of surgery in this specific patient group. This comprehensive analysis helps to establish the long-term impact of different management strategies for asymptomatic severe mitral regurgitation.
Transcript
Today’s date is October 28, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Transcatheter or Surgical Aortic-Valve Replacement in Low-Risk Patients at 7 Years. This study from the PARTNER 3 trial aimed to provide longer-term clinical outcomes and valve durability assessments up to 7 years for low-risk patients with severe, symptomatic aortic stenosis. Patients were randomly assigned in a 1:1 ratio to undergo either transfemoral transcatheter aortic-valve replacement (T.A.V.R.) or surgical aortic-valve replacement. Prior 5-year data from this trial demonstrated similar outcomes between the two procedures. The research underscores the importance of continued long-term evaluation for valve durability and clinical effectiveness in these patients.
Article number two. Using PREVENT Equations to Compare Intensive vs Standard Systolic Blood Pressure Control for Primary Prevention in SPRINT. This secondary analysis of the SPRINT trial aimed to quantify the relative and absolute benefits and harms of intensive versus standard systolic blood pressure (S.B.P.) treatment using the new Predicting Risk of Cardiovascular Disease Events (PREVENT) equations. The PREVENT equations provide enhanced risk stratification by integrating estimated glomerular filtration rate, omitting race, and encompassing total cardiovascular disease events including heart failure. This research established a method for more precisely comparing intensive versus standard S.B.P. control by varying cardiovascular risk levels. The study demonstrates the utility of the PREVENT equations in refining primary prevention strategies for cardiovascular disease.
Article number three. Effect of Intensive Blood Pressure Control on Stroke: A Prespecified Secondary Analysis of the ESPRIT Trial. This prespecified secondary analysis of the ESPRIT trial evaluated the effects of intensive blood pressure control on stroke outcomes. Hypertensive patients with elevated cardiovascular risk were randomized to either intensive treatment, targeting systolic blood pressure (S.B.P.) below 120 millimeters of mercury, or standard treatment, aiming for S.B.P. below 140 millimeters of mercury. The study investigated the comparative impact of these two blood pressure management strategies on preventing stroke. This research highlights the critical role of S.B.P. reduction in stroke prevention, providing a focused comparison of intensive versus standard therapeutic approaches.
Article number four. Clinical Practice of Surgical Treatment for Left-Sided Infective Endocarditis: Nationwide Data from the NIDUS Registry. This observational cohort study utilized nationwide data from the NIDUS Registry to describe the clinical practice of surgical treatment for left-sided infective endocarditis (I.E.). The research specifically aimed to detail the utilization of surgery based on established indications and to assess associated mortality rates in this patient population. By examining a broad national cohort, this study overcomes limitations of prior research from selected tertiary centers, providing a more representative picture of real-world surgical approaches. This comprehensive analysis establishes a valuable benchmark for understanding current surgical interventions and outcomes in left-sided I.E.
Article number five. Long-Term Outcomes of Early Surgery Versus Conventional Treatment for Asymptomatic Severe Mitral Regurgitation: A Propensity Analysis. This observational study employed propensity analysis to compare long-term outcomes of early surgical intervention versus conventional treatment for asymptomatic patients with severe mitral regurgitation. Researchers enrolled 1063 consecutive asymptomatic patients exhibiting severe degenerative mitral regurgitation and preserved left ventricular (L.V.) function, with prospective follow-up from 1996 to 2016. The study provides crucial data to address the clinical controversy surrounding the optimal timing of surgery in this specific patient group. This comprehensive analysis helps to establish the long-term impact of different management strategies for asymptomatic severe mitral regurgitation.
Thank you for listening. Don’t forget to subscribe.
Keywords
PARTNER 3 trial, ESPRIT trial, conventional treatment, stroke prevention, mitral regurgitation, valve durability, early surgery, aortic stenosis, hypertension, systolic blood pressure, intensive blood pressure control, SPRINT trial, surgical aortic-valve replacement, cardiovascular disease primary prevention, mortality, left-sided endocarditis, infective endocarditis, surgical treatment, NIDUS Registry, PREVENT equations, asymptomatic mitral regurgitation, transcatheter aortic-valve replacement, left ventricular function.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post PREVENT Equations Refine Blood Pressure Control. 10/28/25 first appeared on Cardiology Today.
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