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Listen "A.E.D. Training Boosts Cardiac Arrest Survival. 10/29/25"
Episode Synopsis
Welcome to Cardiology Today – Recorded October 29, 2025. This episode summarizes 5 key cardiology studies on topics like M.I.N.O.C.A. and multiomics. Key takeaway: A.E.D. Training Boosts Cardiac Arrest Survival..
Article Links:
Article 1: Stratified treatment of myocardial infarction with non-obstructive coronary arteries: the PROMISE trial. (European heart journal)
Article 2: Adaptation of right ventricular function following tricuspid transcatheter edge-to-edge repair. (ESC heart failure)
Article 3: Improved Survival With Automated External Defibrillator-Only Training in a Public-Access Defibrillation Program: A 23-Year Database Analysis of Progetto Vita. (Journal of the American Heart Association)
Article 4: A Multiomics Approach to Defining Target-Organ Injury in Youths With Primary Hypertension: The SHIP AHOY Cohort. (Journal of the American Heart Association)
Article 5: GATA2 Mediates Macrophage Proliferation During Atherosclerosis. (Journal of the American Heart Association)
Full episode page: https://podcast.explainheart.com/podcast/a-e-d-training-boosts-cardiac-arrest-survival-10-29-25/
Featured Articles
Article 1: Stratified treatment of myocardial infarction with non-obstructive coronary arteries: the PROMISE trial.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41150941
Summary: The P.R.O.M.I.S.E. trial is a multicenter randomized study designed to evaluate the optimal management strategy for myocardial infarction with non-obstructive coronary arteries, or M.I.N.O.C.A. This condition is associated with significant mortality, rehospitalization, and angina burden, yet no prior randomized clinical trials had assessed its treatment. The trial’s objective is to determine if a stratified treatment approach improves clinical outcomes for M.I.N.O.C.A. patients compared to standard care. This research establishes a crucial framework to guide future clinical practice for this high-risk patient population.
Article 2: Adaptation of right ventricular function following tricuspid transcatheter edge-to-edge repair.
Journal: ESC heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41147662
Summary: This study characterized changes in right ventricular ejection fraction, or R.V.E.F., following tricuspid transcatheter edge-to-edge repair, or T-T.E.E.R. Patients with significant tricuspid regurgitation underwent T-T.E.E.R. and cardiac magnetic resonance, or C.M.R., imaging, with follow-up C.M.R. performed within one to three months. The research aimed to clarify the impact of T-T.E.E.R. on right ventricular remodeling and its prognostic implications. By classifying patients based on postprocedural R.V. data, this work provides a clearer understanding of right ventricular adaptation after T-T.E.E.R., which is vital for assessing patient outcomes.
Article 3: Improved Survival With Automated External Defibrillator-Only Training in a Public-Access Defibrillation Program: A 23-Year Database Analysis of Progetto Vita.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41147502
Summary: This 23-year database analysis of the Progetto Vita, or P.V., program in Piacenza demonstrates improved survival for out-of-hospital cardiac arrest, or O.H.C.A., using automated external defibrillator, or A.E.D.,-only training. The P.V. project pioneered the first community-based A.E.D. program in Europe, and this extensive analysis provides critical survival data. The study highlights that early defibrillation is crucial for managing fatal arrhythmias, and A.E.D. use effectively minimizes time to defibrillation. This finding underscores the significant public health benefit of simplified A.E.D.-only training in public-access defibrillation programs for enhancing O.H.C.A. survival.
Article 4: A Multiomics Approach to Defining Target-Organ Injury in Youths With Primary Hypertension: The SHIP AHOY Cohort.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41147417
Summary: This study utilized a multiomics approach within the S.H.I.P. A.H.O.Y. cohort to define early cardiovascular target-organ injury in youths with primary hypertension. It included 132 individuals, with a mean age of 15.8 years, who were stratified by blood pressure and left ventricular mass index, or L.V.M.I. The research provides a unique opportunity to explore early cardiovascular damage in an age group largely free of confounding adult comorbidities. This approach is crucial for identifying early biomarkers and intervention points to prevent the progression of hypertension into adult cardiovascular disease.
Article 5: GATA2 Mediates Macrophage Proliferation During Atherosclerosis.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41147413
Summary: This research identified that G.A.T.A.2 mediates macrophage proliferation during atherosclerosis, clarifying a key mechanism behind lesion development. The study employed transcriptomic and histological analysis of human samples to investigate the signals and transcriptional events driving macrophage growth. It found that while monocytes are recruited to lesions, local macrophage proliferation is the primary driver of macrophage accumulation within the vascular intima. This discovery provides a significant therapeutic advance, pinpointing G.A.T.A.2 as a potential novel target for interventions aimed at halting or regressing atherosclerosis progression.
Transcript
Today’s date is October 29, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Stratified treatment of myocardial infarction with non-obstructive coronary arteries: the PROMISE trial. The P.R.O.M.I.S.E. trial is a multicenter randomized study designed to evaluate the optimal management strategy for myocardial infarction with non-obstructive coronary arteries, or M.I.N.O.C.A. This condition is associated with significant mortality, rehospitalization, and angina burden, yet no prior randomized clinical trials had assessed its treatment. The trial’s objective is to determine if a stratified treatment approach improves clinical outcomes for M.I.N.O.C.A. patients compared to standard care. This research establishes a crucial framework to guide future clinical practice for this high-risk patient population.
Article number two. Adaptation of right ventricular function following tricuspid transcatheter edge-to-edge repair. This study characterized changes in right ventricular ejection fraction, or R.V.E.F., following tricuspid transcatheter edge-to-edge repair, or T-T.E.E.R. Patients with significant tricuspid regurgitation underwent T-T.E.E.R. and cardiac magnetic resonance, or C.M.R., imaging, with follow-up C.M.R. performed within one to three months. The research aimed to clarify the impact of T-T.E.E.R. on right ventricular remodeling and its prognostic implications. By classifying patients based on postprocedural R.V. data, this work provides a clearer understanding of right ventricular adaptation after T-T.E.E.R., which is vital for assessing patient outcomes.
Article number three. Improved Survival With Automated External Defibrillator-Only Training in a Public-Access Defibrillation Program: A 23-Year Database Analysis of Progetto Vita. This 23-year database analysis of the Progetto Vita, or P.V., program in Piacenza demonstrates improved survival for out-of-hospital cardiac arrest, or O.H.C.A., using automated external defibrillator, or A.E.D.,-only training. The P.V. project pioneered the first community-based A.E.D. program in Europe, and this extensive analysis provides critical survival data. The study highlights that early defibrillation is crucial for managing fatal arrhythmias, and A.E.D. use effectively minimizes time to defibrillation. This finding underscores the significant public health benefit of simplified A.E.D.-only training in public-access defibrillation programs for enhancing O.H.C.A. survival.
Article number four. A Multiomics Approach to Defining Target-Organ Injury in Youths With Primary Hypertension: The SHIP AHOY Cohort. This study utilized a multiomics approach within the S.H.I.P. A.H.O.Y. cohort to define early cardiovascular target-organ injury in youths with primary hypertension. It included 132 individuals, with a mean age of 15.8 years, who were stratified by blood pressure and left ventricular mass index, or L.V.M.I. The research provides a unique opportunity to explore early cardiovascular damage in an age group largely free of confounding adult comorbidities. This approach is crucial for identifying early biomarkers and intervention points to prevent the progression of hypertension into adult cardiovascular disease.
Article number five. GATA2 Mediates Macrophage Proliferation During Atherosclerosis. This research identified that G.A.T.A.2 mediates macrophage proliferation during atherosclerosis, clarifying a key mechanism behind lesion development. The study employed transcriptomic and histological analysis of human samples to investigate the signals and transcriptional events driving macrophage growth. It found that while monocytes are recruited to lesions, local macrophage proliferation is the primary driver of macrophage accumulation within the vascular intima. This discovery provides a significant therapeutic advance, pinpointing G.A.T.A.2 as a potential novel target for interventions aimed at halting or regressing atherosclerosis progression.
Thank you for listening. Don’t forget to subscribe.
Keywords
M.I.N.O.C.A., multiomics, stratified treatment, target-organ injury, primary hypertension, myocardial infarction with non-obstructive coronary arteries, right ventricular ejection fraction, tricuspid transcatheter edge-to-edge repair, left ventricular mass index, transcriptional events, randomized trial, macrophage proliferation, cardiac magnetic resonance, tricuspid regurgitation, S.H.I.P. A.H.O.Y. cohort, atherosclerosis, automated external defibrillator, survival data, G.A.T.A.2, public-access defibrillation, lipid-laden macrophages, A.E.D. training, T-T.E.E.R., O.H.C.A., clinical outcomes, out-of-hospital cardiac arrest.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post A.E.D. Training Boosts Cardiac Arrest Survival. 10/29/25 first appeared on Cardiology Today.
Article Links:
Article 1: Stratified treatment of myocardial infarction with non-obstructive coronary arteries: the PROMISE trial. (European heart journal)
Article 2: Adaptation of right ventricular function following tricuspid transcatheter edge-to-edge repair. (ESC heart failure)
Article 3: Improved Survival With Automated External Defibrillator-Only Training in a Public-Access Defibrillation Program: A 23-Year Database Analysis of Progetto Vita. (Journal of the American Heart Association)
Article 4: A Multiomics Approach to Defining Target-Organ Injury in Youths With Primary Hypertension: The SHIP AHOY Cohort. (Journal of the American Heart Association)
Article 5: GATA2 Mediates Macrophage Proliferation During Atherosclerosis. (Journal of the American Heart Association)
Full episode page: https://podcast.explainheart.com/podcast/a-e-d-training-boosts-cardiac-arrest-survival-10-29-25/
Featured Articles
Article 1: Stratified treatment of myocardial infarction with non-obstructive coronary arteries: the PROMISE trial.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41150941
Summary: The P.R.O.M.I.S.E. trial is a multicenter randomized study designed to evaluate the optimal management strategy for myocardial infarction with non-obstructive coronary arteries, or M.I.N.O.C.A. This condition is associated with significant mortality, rehospitalization, and angina burden, yet no prior randomized clinical trials had assessed its treatment. The trial’s objective is to determine if a stratified treatment approach improves clinical outcomes for M.I.N.O.C.A. patients compared to standard care. This research establishes a crucial framework to guide future clinical practice for this high-risk patient population.
Article 2: Adaptation of right ventricular function following tricuspid transcatheter edge-to-edge repair.
Journal: ESC heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41147662
Summary: This study characterized changes in right ventricular ejection fraction, or R.V.E.F., following tricuspid transcatheter edge-to-edge repair, or T-T.E.E.R. Patients with significant tricuspid regurgitation underwent T-T.E.E.R. and cardiac magnetic resonance, or C.M.R., imaging, with follow-up C.M.R. performed within one to three months. The research aimed to clarify the impact of T-T.E.E.R. on right ventricular remodeling and its prognostic implications. By classifying patients based on postprocedural R.V. data, this work provides a clearer understanding of right ventricular adaptation after T-T.E.E.R., which is vital for assessing patient outcomes.
Article 3: Improved Survival With Automated External Defibrillator-Only Training in a Public-Access Defibrillation Program: A 23-Year Database Analysis of Progetto Vita.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41147502
Summary: This 23-year database analysis of the Progetto Vita, or P.V., program in Piacenza demonstrates improved survival for out-of-hospital cardiac arrest, or O.H.C.A., using automated external defibrillator, or A.E.D.,-only training. The P.V. project pioneered the first community-based A.E.D. program in Europe, and this extensive analysis provides critical survival data. The study highlights that early defibrillation is crucial for managing fatal arrhythmias, and A.E.D. use effectively minimizes time to defibrillation. This finding underscores the significant public health benefit of simplified A.E.D.-only training in public-access defibrillation programs for enhancing O.H.C.A. survival.
Article 4: A Multiomics Approach to Defining Target-Organ Injury in Youths With Primary Hypertension: The SHIP AHOY Cohort.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41147417
Summary: This study utilized a multiomics approach within the S.H.I.P. A.H.O.Y. cohort to define early cardiovascular target-organ injury in youths with primary hypertension. It included 132 individuals, with a mean age of 15.8 years, who were stratified by blood pressure and left ventricular mass index, or L.V.M.I. The research provides a unique opportunity to explore early cardiovascular damage in an age group largely free of confounding adult comorbidities. This approach is crucial for identifying early biomarkers and intervention points to prevent the progression of hypertension into adult cardiovascular disease.
Article 5: GATA2 Mediates Macrophage Proliferation During Atherosclerosis.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41147413
Summary: This research identified that G.A.T.A.2 mediates macrophage proliferation during atherosclerosis, clarifying a key mechanism behind lesion development. The study employed transcriptomic and histological analysis of human samples to investigate the signals and transcriptional events driving macrophage growth. It found that while monocytes are recruited to lesions, local macrophage proliferation is the primary driver of macrophage accumulation within the vascular intima. This discovery provides a significant therapeutic advance, pinpointing G.A.T.A.2 as a potential novel target for interventions aimed at halting or regressing atherosclerosis progression.
Transcript
Today’s date is October 29, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Stratified treatment of myocardial infarction with non-obstructive coronary arteries: the PROMISE trial. The P.R.O.M.I.S.E. trial is a multicenter randomized study designed to evaluate the optimal management strategy for myocardial infarction with non-obstructive coronary arteries, or M.I.N.O.C.A. This condition is associated with significant mortality, rehospitalization, and angina burden, yet no prior randomized clinical trials had assessed its treatment. The trial’s objective is to determine if a stratified treatment approach improves clinical outcomes for M.I.N.O.C.A. patients compared to standard care. This research establishes a crucial framework to guide future clinical practice for this high-risk patient population.
Article number two. Adaptation of right ventricular function following tricuspid transcatheter edge-to-edge repair. This study characterized changes in right ventricular ejection fraction, or R.V.E.F., following tricuspid transcatheter edge-to-edge repair, or T-T.E.E.R. Patients with significant tricuspid regurgitation underwent T-T.E.E.R. and cardiac magnetic resonance, or C.M.R., imaging, with follow-up C.M.R. performed within one to three months. The research aimed to clarify the impact of T-T.E.E.R. on right ventricular remodeling and its prognostic implications. By classifying patients based on postprocedural R.V. data, this work provides a clearer understanding of right ventricular adaptation after T-T.E.E.R., which is vital for assessing patient outcomes.
Article number three. Improved Survival With Automated External Defibrillator-Only Training in a Public-Access Defibrillation Program: A 23-Year Database Analysis of Progetto Vita. This 23-year database analysis of the Progetto Vita, or P.V., program in Piacenza demonstrates improved survival for out-of-hospital cardiac arrest, or O.H.C.A., using automated external defibrillator, or A.E.D.,-only training. The P.V. project pioneered the first community-based A.E.D. program in Europe, and this extensive analysis provides critical survival data. The study highlights that early defibrillation is crucial for managing fatal arrhythmias, and A.E.D. use effectively minimizes time to defibrillation. This finding underscores the significant public health benefit of simplified A.E.D.-only training in public-access defibrillation programs for enhancing O.H.C.A. survival.
Article number four. A Multiomics Approach to Defining Target-Organ Injury in Youths With Primary Hypertension: The SHIP AHOY Cohort. This study utilized a multiomics approach within the S.H.I.P. A.H.O.Y. cohort to define early cardiovascular target-organ injury in youths with primary hypertension. It included 132 individuals, with a mean age of 15.8 years, who were stratified by blood pressure and left ventricular mass index, or L.V.M.I. The research provides a unique opportunity to explore early cardiovascular damage in an age group largely free of confounding adult comorbidities. This approach is crucial for identifying early biomarkers and intervention points to prevent the progression of hypertension into adult cardiovascular disease.
Article number five. GATA2 Mediates Macrophage Proliferation During Atherosclerosis. This research identified that G.A.T.A.2 mediates macrophage proliferation during atherosclerosis, clarifying a key mechanism behind lesion development. The study employed transcriptomic and histological analysis of human samples to investigate the signals and transcriptional events driving macrophage growth. It found that while monocytes are recruited to lesions, local macrophage proliferation is the primary driver of macrophage accumulation within the vascular intima. This discovery provides a significant therapeutic advance, pinpointing G.A.T.A.2 as a potential novel target for interventions aimed at halting or regressing atherosclerosis progression.
Thank you for listening. Don’t forget to subscribe.
Keywords
M.I.N.O.C.A., multiomics, stratified treatment, target-organ injury, primary hypertension, myocardial infarction with non-obstructive coronary arteries, right ventricular ejection fraction, tricuspid transcatheter edge-to-edge repair, left ventricular mass index, transcriptional events, randomized trial, macrophage proliferation, cardiac magnetic resonance, tricuspid regurgitation, S.H.I.P. A.H.O.Y. cohort, atherosclerosis, automated external defibrillator, survival data, G.A.T.A.2, public-access defibrillation, lipid-laden macrophages, A.E.D. training, T-T.E.E.R., O.H.C.A., clinical outcomes, out-of-hospital cardiac arrest.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post A.E.D. Training Boosts Cardiac Arrest Survival. 10/29/25 first appeared on Cardiology Today.
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