Welcome to Cardiology Today – Recorded October 28, 2025. This episode summarizes 5 key cardiology studies on topics like cardiac fibrosis and neurodevelopmental outcomes. Key takeaway: Nup35 Controls Heart Remodeling.
Article Links:
Article 1: Neurodevelopmental Outcomes in Early Adolescence: The Pediatric Heart Network’s Single Ventricle Reconstruction Trial. (Circulation)
Article 2: Effect of Remote Ischemic Preconditioning on Myocardial Injury in Noncardiac Surgery: The PRINCE Randomized Clinical Trial. (Circulation)
Article 3: The Role of the Collateral Circulation in Stable Angina: An Invasive Placebo-Controlled Study. (Circulation)
Article 4: Cardiomyocyte Nucleoporin 35 regulates pathological cardiac remodeling through Wif1. (Cardiovascular research)
Article 5: New insights into foam cells in atherosclerosis. (Cardiovascular research)
Full episode page: https://podcast.explainheart.com/podcast/nup35-controls-heart-remodeling-10-28-25/
Featured Articles
Article 1: Neurodevelopmental Outcomes in Early Adolescence: The Pediatric Heart Network’s Single Ventricle Reconstruction Trial.
Journal: Circulation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40671650
Summary: This study from the Pediatric Heart Network’s S.V.R. I.I.I. trial evaluated neurodevelopmental and functional outcomes in early adolescence for survivors of hypoplastic left heart syndrome. It enrolled adolescents who were randomized to different surgical shunt types during the Norwood procedure as neonates, conducting multifaceted in-person assessments. The research provides critical long-term follow-up data on the impact of initial surgical approaches on these significant morbidities. This comprehensive evaluation is crucial for informing care strategies and improving long-term quality of life for this vulnerable patient population.
Article 2: Effect of Remote Ischemic Preconditioning on Myocardial Injury in Noncardiac Surgery: The PRINCE Randomized Clinical Trial.
Journal: Circulation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40511609
Summary: The multinational P.R.I.N.C.E. randomized clinical trial investigated the effect of remote ischemic preconditioning on myocardial injury during noncardiac surgery. Adult high-risk patients were randomly assigned to receive either remote ischemic preconditioning, involving three five-minute cycles of upper limb ischemia, or sham treatment after anesthesia induction. This robust, double-blind study aimed to definitively determine if remote ischemic preconditioning decreases postoperative myocardial injury and other complications. The trial establishes crucial evidence regarding the utility of remote ischemic preconditioning in improving outcomes for patients undergoing major noncardiac surgical procedures.
Article 3: The Role of the Collateral Circulation in Stable Angina: An Invasive Placebo-Controlled Study.
Journal: Circulation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41144984
Summary: This n-of-one invasive placebo-controlled study explored the relationship between myocardial ischemia, collateral circulation, and angina symptoms in stable coronary artery disease. Fifty-one participants with severe single-vessel coronary artery disease and angina were recruited for this investigation. The research aimed to clarify why the burden of ischemia often shows little correlation with angina severity and to explore the association between progressive collateral recruitment and ischemic preconditioning. This study provides a detailed understanding of the collateral circulation’s role in modulating symptoms and offering ischemic protection in stable angina patients.
Article 4: Cardiomyocyte Nucleoporin 35 regulates pathological cardiac remodeling through Wif1.
Journal: Cardiovascular research
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41145234
Summary: This research identified Cardiomyocyte Nucleoporin 35 as a key regulator of pathological cardiac remodeling. The study demonstrated that cardiac Nucleoporin 35 expression is significantly down-regulated during Angiotensin I.I.- and transverse aortic constriction-induced remodeling in mice. Cardiac-specific Nucleoporin 35 knockout mice displayed severe cardiac fibrosis, hypertrophy, and cardiac dysfunction, while its overexpression mitigated these pathologies by modulating Wif1. This discovery reveals a crucial mechanistic pathway underlying cardiac remodeling and presents a promising therapeutic target for heart disease.
Article 5: New insights into foam cells in atherosclerosis.
Journal: Cardiovascular research
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41144636
Summary: This comprehensive review advanced understanding of cholesterol-containing foam cells, which drive atherosclerosis and related cardiovascular events. It detailed how excessive foam cell accumulation leads to apoptosis, necrosis, necrotic core formation, and plaque destabilization. The review highlighted the persistent challenges in developing effective targeted therapies despite the therapeutic potential of targeting foam cells for atherosclerosis treatment. This synthesis of knowledge is vital for informing future research directions and developing novel strategies to prevent and treat atherosclerotic disease.
Transcript

Today’s date is October 28, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Neurodevelopmental Outcomes in Early Adolescence: The Pediatric Heart Network’s Single Ventricle Reconstruction Trial. This study from the Pediatric Heart Network’s S.V.R. I.I.I. trial evaluated neurodevelopmental and functional outcomes in early adolescence for survivors of hypoplastic left heart syndrome. It enrolled adolescents who were randomized to different surgical shunt types during the Norwood procedure as neonates, conducting multifaceted in-person assessments. The research provides critical long-term follow-up data on the impact of initial surgical approaches on these significant morbidities. This comprehensive evaluation is crucial for informing care strategies and improving long-term quality of life for this vulnerable patient population.
Article number two. Effect of Remote Ischemic Preconditioning on Myocardial Injury in Noncardiac Surgery: The PRINCE Randomized Clinical Trial. The multinational P.R.I.N.C.E. randomized clinical trial investigated the effect of remote ischemic preconditioning on myocardial injury during noncardiac surgery. Adult high-risk patients were randomly assigned to receive either remote ischemic preconditioning, involving three five-minute cycles of upper limb ischemia, or sham treatment after anesthesia induction. This robust, double-blind study aimed to definitively determine if remote ischemic preconditioning decreases postoperative myocardial injury and other complications. The trial establishes crucial evidence regarding the utility of remote ischemic preconditioning in improving outcomes for patients undergoing major noncardiac surgical procedures.
Article number three. The Role of the Collateral Circulation in Stable Angina: An Invasive Placebo-Controlled Study. This n-of-one invasive placebo-controlled study explored the relationship between myocardial ischemia, collateral circulation, and angina symptoms in stable coronary artery disease. Fifty-one participants with severe single-vessel coronary artery disease and angina were recruited for this investigation. The research aimed to clarify why the burden of ischemia often shows little correlation with angina severity and to explore the association between progressive collateral recruitment and ischemic preconditioning. This study provides a detailed understanding of the collateral circulation’s role in modulating symptoms and offering ischemic protection in stable angina patients.
Article number four. Cardiomyocyte Nucleoporin 35 regulates pathological cardiac remodeling through Wif1. This research identified Cardiomyocyte Nucleoporin 35 as a key regulator of pathological cardiac remodeling. The study demonstrated that cardiac Nucleoporin 35 expression is significantly down-regulated during Angiotensin I.I.- and transverse aortic constriction-induced remodeling in mice. Cardiac-specific Nucleoporin 35 knockout mice displayed severe cardiac fibrosis, hypertrophy, and cardiac dysfunction, while its overexpression mitigated these pathologies by modulating Wif1. This discovery reveals a crucial mechanistic pathway underlying cardiac remodeling and presents a promising therapeutic target for heart disease.
Article number five. New insights into foam cells in atherosclerosis. This comprehensive review advanced understanding of cholesterol-containing foam cells, which drive atherosclerosis and related cardiovascular events. It detailed how excessive foam cell accumulation leads to apoptosis, necrosis, necrotic core formation, and plaque destabilization. The review highlighted the persistent challenges in developing effective targeted therapies despite the therapeutic potential of targeting foam cells for atherosclerosis treatment. This synthesis of knowledge is vital for informing future research directions and developing novel strategies to prevent and treat atherosclerotic disease.
Thank you for listening. Don’t forget to subscribe.


Keywords
cardiac fibrosis, neurodevelopmental outcomes, S.V.R. I.I.I. trial, foam cells, Norwood procedure, noncardiac surgery, single ventricle, plaque destabilization, cholesterol, coronary artery disease, cardiomyocyte, ischemic preconditioning, collateral circulation, myocardial injury, hypoplastic left heart syndrome, myocardial ischemia, atherosclerosis, remote ischemic preconditioning, cardiovascular events, P.R.I.N.C.E. trial, Wif1, stable angina, randomized clinical trial, cardiac remodeling, Nucleoporin 35.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post Nup35 Controls Heart Remodeling 10/28/25 first appeared on Cardiology Today.

Ver todos los episodios