ZARZA We are Zarza, the prestigious firm behind major projects in information technology.
Listen "Contractile Reserve Predicts T.A.V.I. Success 09/22/25"
Episode Synopsis
Welcome to Cardiology Today – Recorded September 22, 2025. This episode summarizes 5 key cardiology studies on topics like Left Ventricular Dysfunction and Genetic Testing. Key takeaway: Contractile Reserve Predicts T.A.V.I. Success.
Article Links:
Article 1: Obesity and inactivity cluster the strongest risk factor for the development of heart failure in a population-based study. (International journal of cardiology)
Article 2: The impact of contractile reserve on clinical outcomes in patients with left ventricular dysfunction undergoing TAVI. (International journal of cardiology)
Article 3: Head-up tilt testing in patients with suspected vasovagal syncope: A meta-regression modelling. (International journal of cardiology)
Article 4: Stroke Recurrence and Pregnancy Outcomes in the Subsequent Pregnancies After Maternal Ischemic Stroke. (Stroke)
Article 5: Systematic Genetic Assessment in Young Patients With Cryptogenic Stroke: The ES-EASY project. (Stroke)
Full episode page: https://podcast.explainheart.com/podcast/contractile-reserve-predicts-t-a-v-i-success-09-22-25/
Featured Articles
Article 1: Obesity and inactivity cluster the strongest risk factor for the development of heart failure in a population-based study.
Journal: International journal of cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40976358
Summary: This prospective study of over six thousand individuals revealed that obesity and inactivity are the strongest risk factors for developing heart failure. The study used latent class analysis to identify multimorbidity patterns and found that clusters with obesity and inactivity were most strongly associated with incident heart failure, regardless of ejection fraction. These findings underscore the critical importance of lifestyle interventions targeting obesity and physical activity to reduce heart failure risk.
Article 2: The impact of contractile reserve on clinical outcomes in patients with left ventricular dysfunction undergoing TAVI.
Journal: International journal of cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40976357
Summary: This multicenter registry study evaluated the prognostic value of contractile reserve, assessed by dobutamine stress echocardiography, in patients with left ventricular dysfunction undergoing transcatheter aortic valve implantation. The presence of contractile reserve was significantly associated with improved left ventricular ejection fraction recovery and better clinical outcomes post-transcatheter aortic valve implantation. These results suggest that dobutamine stress echocardiography can help select appropriate candidates for transcatheter aortic valve implantation among patients with severe left ventricular dysfunction.
Article 3: Head-up tilt testing in patients with suspected vasovagal syncope: A meta-regression modelling.
Journal: International journal of cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40976356
Summary: This meta-regression analysis of ninety-seven articles investigated the influence of age and instrumental parameters on head-up tilt testing outcomes in patients with suspected vasovagal syncope. The analysis found that age and the use of isoproterenol potentiation significantly affected the positivity rate of head-up tilt testing. These findings highlight the importance of considering patient age and provocation protocols when interpreting head-up tilt testing results for syncope diagnosis.
Article 4: Stroke Recurrence and Pregnancy Outcomes in the Subsequent Pregnancies After Maternal Ischemic Stroke.
Journal: Stroke
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40970275
Summary: This study examined subsequent pregnancies in women with a history of ischemic stroke during pregnancy or the puerperium. Results showed a significant risk of stroke recurrence in subsequent pregnancies, as well as increased risks of other complications. The study underscores the need for careful secondary prevention strategies and close monitoring during subsequent pregnancies in women with prior maternal ischemic stroke.
Article 5: Systematic Genetic Assessment in Young Patients With Cryptogenic Stroke: The ES-EASY project.
Journal: Stroke
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40970272
Summary: This retrospective observational cohort study assessed the value of systematic genetic analyses in young adults with cryptogenic stroke. The project aimed to estimate the frequency of genetic disorders in these patients. The study is ongoing, but preliminary data suggests that genetic testing may uncover rare causes of stroke in young individuals, potentially influencing treatment strategies.
Transcript
Today’s date is September 22, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Obesity and inactivity cluster the strongest risk factor for the development of heart failure in a population-based study. This prospective study of over six thousand individuals revealed that obesity and inactivity are the strongest risk factors for developing heart failure. The study used latent class analysis to identify multimorbidity patterns and found that clusters with obesity and inactivity were most strongly associated with incident heart failure, regardless of ejection fraction. These findings underscore the critical importance of lifestyle interventions targeting obesity and physical activity to reduce heart failure risk.
Article number two. The impact of contractile reserve on clinical outcomes in patients with left ventricular dysfunction undergoing TAVI. This multicenter registry study evaluated the prognostic value of contractile reserve, assessed by dobutamine stress echocardiography, in patients with left ventricular dysfunction undergoing transcatheter aortic valve implantation. The presence of contractile reserve was significantly associated with improved left ventricular ejection fraction recovery and better clinical outcomes post-transcatheter aortic valve implantation. These results suggest that dobutamine stress echocardiography can help select appropriate candidates for transcatheter aortic valve implantation among patients with severe left ventricular dysfunction.
Article number three. Head-up tilt testing in patients with suspected vasovagal syncope: A meta-regression modelling. This meta-regression analysis of ninety-seven articles investigated the influence of age and instrumental parameters on head-up tilt testing outcomes in patients with suspected vasovagal syncope. The analysis found that age and the use of isoproterenol potentiation significantly affected the positivity rate of head-up tilt testing. These findings highlight the importance of considering patient age and provocation protocols when interpreting head-up tilt testing results for syncope diagnosis.
Article number four. Stroke Recurrence and Pregnancy Outcomes in the Subsequent Pregnancies After Maternal Ischemic Stroke. This study examined subsequent pregnancies in women with a history of ischemic stroke during pregnancy or the puerperium. Results showed a significant risk of stroke recurrence in subsequent pregnancies, as well as increased risks of other complications. The study underscores the need for careful secondary prevention strategies and close monitoring during subsequent pregnancies in women with prior maternal ischemic stroke.
Article number five. Systematic Genetic Assessment in Young Patients With Cryptogenic Stroke: The E.S.-EASY project. This retrospective observational cohort study assessed the value of systematic genetic analyses in young adults with cryptogenic stroke. The project aimed to estimate the frequency of genetic disorders in these patients. The study is ongoing, but preliminary data suggests that genetic testing may uncover rare causes of stroke in young individuals, potentially influencing treatment strategies.
Thank you for listening. Don’t forget to subscribe.
Keywords
Left Ventricular Dysfunction, Genetic Testing, Dobutamine Stress Echocardiography, Cryptogenic Stroke, Secondary Prevention, Meta-Regression, Obesity, Inactivity, Vasovagal Syncope, Isoproterenol, Transcatheter Aortic Valve Implantation, Heart Failure, Stroke Etiology, Prevention, Stroke Recurrence, Young Adults, Pregnancy, Contractile Reserve, Aortic Stenosis, Head-Up Tilt Testing, Ischemic Stroke, Maternal Health, Multimorbidity, Genetic Disorders, Syncope Diagnosis.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post Contractile Reserve Predicts T.A.V.I. Success 09/22/25 first appeared on Cardiology Today.
Article Links:
Article 1: Obesity and inactivity cluster the strongest risk factor for the development of heart failure in a population-based study. (International journal of cardiology)
Article 2: The impact of contractile reserve on clinical outcomes in patients with left ventricular dysfunction undergoing TAVI. (International journal of cardiology)
Article 3: Head-up tilt testing in patients with suspected vasovagal syncope: A meta-regression modelling. (International journal of cardiology)
Article 4: Stroke Recurrence and Pregnancy Outcomes in the Subsequent Pregnancies After Maternal Ischemic Stroke. (Stroke)
Article 5: Systematic Genetic Assessment in Young Patients With Cryptogenic Stroke: The ES-EASY project. (Stroke)
Full episode page: https://podcast.explainheart.com/podcast/contractile-reserve-predicts-t-a-v-i-success-09-22-25/
Featured Articles
Article 1: Obesity and inactivity cluster the strongest risk factor for the development of heart failure in a population-based study.
Journal: International journal of cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40976358
Summary: This prospective study of over six thousand individuals revealed that obesity and inactivity are the strongest risk factors for developing heart failure. The study used latent class analysis to identify multimorbidity patterns and found that clusters with obesity and inactivity were most strongly associated with incident heart failure, regardless of ejection fraction. These findings underscore the critical importance of lifestyle interventions targeting obesity and physical activity to reduce heart failure risk.
Article 2: The impact of contractile reserve on clinical outcomes in patients with left ventricular dysfunction undergoing TAVI.
Journal: International journal of cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40976357
Summary: This multicenter registry study evaluated the prognostic value of contractile reserve, assessed by dobutamine stress echocardiography, in patients with left ventricular dysfunction undergoing transcatheter aortic valve implantation. The presence of contractile reserve was significantly associated with improved left ventricular ejection fraction recovery and better clinical outcomes post-transcatheter aortic valve implantation. These results suggest that dobutamine stress echocardiography can help select appropriate candidates for transcatheter aortic valve implantation among patients with severe left ventricular dysfunction.
Article 3: Head-up tilt testing in patients with suspected vasovagal syncope: A meta-regression modelling.
Journal: International journal of cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40976356
Summary: This meta-regression analysis of ninety-seven articles investigated the influence of age and instrumental parameters on head-up tilt testing outcomes in patients with suspected vasovagal syncope. The analysis found that age and the use of isoproterenol potentiation significantly affected the positivity rate of head-up tilt testing. These findings highlight the importance of considering patient age and provocation protocols when interpreting head-up tilt testing results for syncope diagnosis.
Article 4: Stroke Recurrence and Pregnancy Outcomes in the Subsequent Pregnancies After Maternal Ischemic Stroke.
Journal: Stroke
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40970275
Summary: This study examined subsequent pregnancies in women with a history of ischemic stroke during pregnancy or the puerperium. Results showed a significant risk of stroke recurrence in subsequent pregnancies, as well as increased risks of other complications. The study underscores the need for careful secondary prevention strategies and close monitoring during subsequent pregnancies in women with prior maternal ischemic stroke.
Article 5: Systematic Genetic Assessment in Young Patients With Cryptogenic Stroke: The ES-EASY project.
Journal: Stroke
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40970272
Summary: This retrospective observational cohort study assessed the value of systematic genetic analyses in young adults with cryptogenic stroke. The project aimed to estimate the frequency of genetic disorders in these patients. The study is ongoing, but preliminary data suggests that genetic testing may uncover rare causes of stroke in young individuals, potentially influencing treatment strategies.
Transcript
Today’s date is September 22, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Obesity and inactivity cluster the strongest risk factor for the development of heart failure in a population-based study. This prospective study of over six thousand individuals revealed that obesity and inactivity are the strongest risk factors for developing heart failure. The study used latent class analysis to identify multimorbidity patterns and found that clusters with obesity and inactivity were most strongly associated with incident heart failure, regardless of ejection fraction. These findings underscore the critical importance of lifestyle interventions targeting obesity and physical activity to reduce heart failure risk.
Article number two. The impact of contractile reserve on clinical outcomes in patients with left ventricular dysfunction undergoing TAVI. This multicenter registry study evaluated the prognostic value of contractile reserve, assessed by dobutamine stress echocardiography, in patients with left ventricular dysfunction undergoing transcatheter aortic valve implantation. The presence of contractile reserve was significantly associated with improved left ventricular ejection fraction recovery and better clinical outcomes post-transcatheter aortic valve implantation. These results suggest that dobutamine stress echocardiography can help select appropriate candidates for transcatheter aortic valve implantation among patients with severe left ventricular dysfunction.
Article number three. Head-up tilt testing in patients with suspected vasovagal syncope: A meta-regression modelling. This meta-regression analysis of ninety-seven articles investigated the influence of age and instrumental parameters on head-up tilt testing outcomes in patients with suspected vasovagal syncope. The analysis found that age and the use of isoproterenol potentiation significantly affected the positivity rate of head-up tilt testing. These findings highlight the importance of considering patient age and provocation protocols when interpreting head-up tilt testing results for syncope diagnosis.
Article number four. Stroke Recurrence and Pregnancy Outcomes in the Subsequent Pregnancies After Maternal Ischemic Stroke. This study examined subsequent pregnancies in women with a history of ischemic stroke during pregnancy or the puerperium. Results showed a significant risk of stroke recurrence in subsequent pregnancies, as well as increased risks of other complications. The study underscores the need for careful secondary prevention strategies and close monitoring during subsequent pregnancies in women with prior maternal ischemic stroke.
Article number five. Systematic Genetic Assessment in Young Patients With Cryptogenic Stroke: The E.S.-EASY project. This retrospective observational cohort study assessed the value of systematic genetic analyses in young adults with cryptogenic stroke. The project aimed to estimate the frequency of genetic disorders in these patients. The study is ongoing, but preliminary data suggests that genetic testing may uncover rare causes of stroke in young individuals, potentially influencing treatment strategies.
Thank you for listening. Don’t forget to subscribe.
Keywords
Left Ventricular Dysfunction, Genetic Testing, Dobutamine Stress Echocardiography, Cryptogenic Stroke, Secondary Prevention, Meta-Regression, Obesity, Inactivity, Vasovagal Syncope, Isoproterenol, Transcatheter Aortic Valve Implantation, Heart Failure, Stroke Etiology, Prevention, Stroke Recurrence, Young Adults, Pregnancy, Contractile Reserve, Aortic Stenosis, Head-Up Tilt Testing, Ischemic Stroke, Maternal Health, Multimorbidity, Genetic Disorders, Syncope Diagnosis.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post Contractile Reserve Predicts T.A.V.I. Success 09/22/25 first appeared on Cardiology Today.
In God we trust