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Listen "Cell-Free DNA Predicts LVAD Outcomes 11/28/25"
Episode Synopsis
Welcome to Cardiology Today – Recorded November 28, 2025. This episode summarizes 5 key cardiology studies on topics like abdominal aortic aneurysm and diabetic cardiomyopathy. Key takeaway: Cell-Free DNA Predicts LVAD Outcomes.
Article Links:
Article 1: Neutrophil extracellular traps and peptidylarginine deiminase 4-mediated inflammasome activation link diabetes to cardiorenal injury and heart failure. (European heart journal)
Article 2: Cell-Free DNA Profiles End-Organ Injury and Predicts Outcomes in Advanced Heart Failure With Left Ventricular Assist Device Implantation. (Circulation. Heart failure)
Article 3: Immune Cell Type-Specific DNA Methylation Regions Associate With 24-Hour Blood Pressure Regulation in Black People. (Journal of the American Heart Association)
Article 4: Vascular and Neural Transcriptomics Reveal Stage-Dependent Pathways to Inflammation and Cognitive Dysfunction in a Rat Model of Hypertension. (Journal of the American Heart Association)
Article 5: C-C Chemokine Receptor 4 Deficiency Protects Against Abdominal Aortic Aneurysm Formation. (Journal of the American Heart Association)
Full episode page: https://podcast.explainheart.com/podcast/cell-free-dna-predicts-lvad-outcomes-11-28-25/
Featured Articles
Article 1: Neutrophil extracellular traps and peptidylarginine deiminase 4-mediated inflammasome activation link diabetes to cardiorenal injury and heart failure.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41307910
Summary: This study demonstrated that neutrophil extracellular traps (NETs) and peptidylarginine deiminase 4 (PAD4)-mediated inflammasome activation link diabetes to cardiorenal injury and heart failure. Endomyocardial biopsies from heart failure patients showed the presence of NETs, indicating their role in human disease pathology. Research involving wild-type and PAD4-deficient mice further elucidated this connection in diabetic cardiomyopathy and kidney disease. This establishes a critical mechanistic link between diabetes and its severe cardiovascular and renal complications.
Article 2: Cell-Free DNA Profiles End-Organ Injury and Predicts Outcomes in Advanced Heart Failure With Left Ventricular Assist Device Implantation.
Journal: Circulation. Heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41307146
Summary: This study demonstrated that plasma cell-free DNA (cfDNA) accurately profiles end-organ injury and predicts outcomes in patients with advanced heart failure receiving left ventricular assist device (LVAD) implantation. The research identified cfDNA as a valuable biomarker for risk stratification following LVAD placement. It analyzed a multicenter prospective cohort of heart failure patients, including those with and without LVADs, to establish this predictive capability. This finding offers a novel approach to assess adverse events and improve risk management in this patient population.
Article 3: Immune Cell Type-Specific DNA Methylation Regions Associate With 24-Hour Blood Pressure Regulation in Black People.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294148
Summary: This study found that immune cell type-specific DNA methylation regions associate with 24-hour blood pressure regulation in Black people. Researchers established this connection by employing advanced deconvolution algorithms to analyze reduced representation bisulfite sequencing data. The study identified specific epigenetic markers within immune cells that play a role in blood pressure control. These findings highlight a novel mechanism linking immune cell epigenetics to hypertension risk within this specific population.
Article 4: Vascular and Neural Transcriptomics Reveal Stage-Dependent Pathways to Inflammation and Cognitive Dysfunction in a Rat Model of Hypertension.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294147
Summary: This study revealed stage-dependent vascular and neural transcriptomic pathways leading to inflammation and cognitive dysfunction in a rat model of hypertension. Researchers identified specific molecular and cellular mechanisms occurring at different stages of hypertension progression. The findings indicate distinct inflammatory and neural changes contributing to cerebral microvascular dysfunction and increased dementia risk. This research provides crucial insights into the complex pathogenesis of hypertension-related cognitive decline.
Article 5: C-C Chemokine Receptor 4 Deficiency Protects Against Abdominal Aortic Aneurysm Formation.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294146
Summary: This study found that C-C chemokine receptor 4 (CCR4) deficiency protects against abdominal aortic aneurysm (AAA) formation. Researchers observed this protective effect in hypercholesterolemic CCR4-deficient mice. The findings suggest that CCR4, predominantly expressed on T cells, plays a critical role in the dysregulated immune system driving chronic vascular inflammation and remodeling in AAA pathogenesis. This establishes CCR4 as a potential therapeutic target for preventing or treating abdominal aortic aneurysm.
Transcript
Today’s date is November 28, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Neutrophil extracellular traps and peptidylarginine deiminase 4-mediated inflammasome activation link diabetes to cardiorenal injury and heart failure. This study demonstrated that neutrophil extracellular traps (NETs) and peptidylarginine deiminase 4 (PAD4)-mediated inflammasome activation link diabetes to cardiorenal injury and heart failure. Endomyocardial biopsies from heart failure patients showed the presence of NETs, indicating their role in human disease pathology. Research involving wild-type and PAD4-deficient mice further elucidated this connection in diabetic cardiomyopathy and kidney disease. This establishes a critical mechanistic link between diabetes and its severe cardiovascular and renal complications.
Article number two. Cell-Free DNA Profiles End-Organ Injury and Predicts Outcomes in Advanced Heart Failure With Left Ventricular Assist Device Implantation. This study demonstrated that plasma cell-free DNA (cfDNA) accurately profiles end-organ injury and predicts outcomes in patients with advanced heart failure receiving left ventricular assist device (LVAD) implantation. The research identified cfDNA as a valuable biomarker for risk stratification following LVAD placement. It analyzed a multicenter prospective cohort of heart failure patients, including those with and without LVADs, to establish this predictive capability. This finding offers a novel approach to assess adverse events and improve risk management in this patient population.
Article number three. Immune Cell Type-Specific DNA Methylation Regions Associate With 24-Hour Blood Pressure Regulation in Black People. This study found that immune cell type-specific DNA methylation regions associate with 24-hour blood pressure regulation in Black people. Researchers established this connection by employing advanced deconvolution algorithms to analyze reduced representation bisulfite sequencing data. The study identified specific epigenetic markers within immune cells that play a role in blood pressure control. These findings highlight a novel mechanism linking immune cell epigenetics to hypertension risk within this specific population.
Article number four. Vascular and Neural Transcriptomics Reveal Stage-Dependent Pathways to Inflammation and Cognitive Dysfunction in a Rat Model of Hypertension. This study revealed stage-dependent vascular and neural transcriptomic pathways leading to inflammation and cognitive dysfunction in a rat model of hypertension. Researchers identified specific molecular and cellular mechanisms occurring at different stages of hypertension progression. The findings indicate distinct inflammatory and neural changes contributing to cerebral microvascular dysfunction and increased dementia risk. This research provides crucial insights into the complex pathogenesis of hypertension-related cognitive decline.
Article number five. C-C Chemokine Receptor 4 Deficiency Protects Against Abdominal Aortic Aneurysm Formation. This study found that C-C chemokine receptor 4 (CCR4) deficiency protects against abdominal aortic aneurysm (AAA) formation. Researchers observed this protective effect in hypercholesterolemic CCR4-deficient mice. The findings suggest that CCR4, predominantly expressed on T cells, plays a critical role in the dysregulated immune system driving chronic vascular inflammation and remodeling in AAA pathogenesis. This establishes CCR4 as a potential therapeutic target for preventing or treating abdominal aortic aneurysm.
Thank you for listening. Don’t forget to subscribe.
Keywords
abdominal aortic aneurysm, diabetic cardiomyopathy, immune cells, cardiorenal injury, Black people, neutrophil extracellular traps, hypertension, immune system, DNA methylation, neural transcriptomics, inflammation, blood pressure regulation, T cells, vascular transcriptomics, heart failure, vascular inflammation, peptidylarginine deiminase 4, biomarker, left ventricular assist device, cognitive dysfunction, end-organ injury, cell-free DNA, C-C chemokine receptor 4.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post Cell-Free DNA Predicts LVAD Outcomes 11/28/25 first appeared on Cardiology Today.
Article Links:
Article 1: Neutrophil extracellular traps and peptidylarginine deiminase 4-mediated inflammasome activation link diabetes to cardiorenal injury and heart failure. (European heart journal)
Article 2: Cell-Free DNA Profiles End-Organ Injury and Predicts Outcomes in Advanced Heart Failure With Left Ventricular Assist Device Implantation. (Circulation. Heart failure)
Article 3: Immune Cell Type-Specific DNA Methylation Regions Associate With 24-Hour Blood Pressure Regulation in Black People. (Journal of the American Heart Association)
Article 4: Vascular and Neural Transcriptomics Reveal Stage-Dependent Pathways to Inflammation and Cognitive Dysfunction in a Rat Model of Hypertension. (Journal of the American Heart Association)
Article 5: C-C Chemokine Receptor 4 Deficiency Protects Against Abdominal Aortic Aneurysm Formation. (Journal of the American Heart Association)
Full episode page: https://podcast.explainheart.com/podcast/cell-free-dna-predicts-lvad-outcomes-11-28-25/
Featured Articles
Article 1: Neutrophil extracellular traps and peptidylarginine deiminase 4-mediated inflammasome activation link diabetes to cardiorenal injury and heart failure.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41307910
Summary: This study demonstrated that neutrophil extracellular traps (NETs) and peptidylarginine deiminase 4 (PAD4)-mediated inflammasome activation link diabetes to cardiorenal injury and heart failure. Endomyocardial biopsies from heart failure patients showed the presence of NETs, indicating their role in human disease pathology. Research involving wild-type and PAD4-deficient mice further elucidated this connection in diabetic cardiomyopathy and kidney disease. This establishes a critical mechanistic link between diabetes and its severe cardiovascular and renal complications.
Article 2: Cell-Free DNA Profiles End-Organ Injury and Predicts Outcomes in Advanced Heart Failure With Left Ventricular Assist Device Implantation.
Journal: Circulation. Heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41307146
Summary: This study demonstrated that plasma cell-free DNA (cfDNA) accurately profiles end-organ injury and predicts outcomes in patients with advanced heart failure receiving left ventricular assist device (LVAD) implantation. The research identified cfDNA as a valuable biomarker for risk stratification following LVAD placement. It analyzed a multicenter prospective cohort of heart failure patients, including those with and without LVADs, to establish this predictive capability. This finding offers a novel approach to assess adverse events and improve risk management in this patient population.
Article 3: Immune Cell Type-Specific DNA Methylation Regions Associate With 24-Hour Blood Pressure Regulation in Black People.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294148
Summary: This study found that immune cell type-specific DNA methylation regions associate with 24-hour blood pressure regulation in Black people. Researchers established this connection by employing advanced deconvolution algorithms to analyze reduced representation bisulfite sequencing data. The study identified specific epigenetic markers within immune cells that play a role in blood pressure control. These findings highlight a novel mechanism linking immune cell epigenetics to hypertension risk within this specific population.
Article 4: Vascular and Neural Transcriptomics Reveal Stage-Dependent Pathways to Inflammation and Cognitive Dysfunction in a Rat Model of Hypertension.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294147
Summary: This study revealed stage-dependent vascular and neural transcriptomic pathways leading to inflammation and cognitive dysfunction in a rat model of hypertension. Researchers identified specific molecular and cellular mechanisms occurring at different stages of hypertension progression. The findings indicate distinct inflammatory and neural changes contributing to cerebral microvascular dysfunction and increased dementia risk. This research provides crucial insights into the complex pathogenesis of hypertension-related cognitive decline.
Article 5: C-C Chemokine Receptor 4 Deficiency Protects Against Abdominal Aortic Aneurysm Formation.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294146
Summary: This study found that C-C chemokine receptor 4 (CCR4) deficiency protects against abdominal aortic aneurysm (AAA) formation. Researchers observed this protective effect in hypercholesterolemic CCR4-deficient mice. The findings suggest that CCR4, predominantly expressed on T cells, plays a critical role in the dysregulated immune system driving chronic vascular inflammation and remodeling in AAA pathogenesis. This establishes CCR4 as a potential therapeutic target for preventing or treating abdominal aortic aneurysm.
Transcript
Today’s date is November 28, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Neutrophil extracellular traps and peptidylarginine deiminase 4-mediated inflammasome activation link diabetes to cardiorenal injury and heart failure. This study demonstrated that neutrophil extracellular traps (NETs) and peptidylarginine deiminase 4 (PAD4)-mediated inflammasome activation link diabetes to cardiorenal injury and heart failure. Endomyocardial biopsies from heart failure patients showed the presence of NETs, indicating their role in human disease pathology. Research involving wild-type and PAD4-deficient mice further elucidated this connection in diabetic cardiomyopathy and kidney disease. This establishes a critical mechanistic link between diabetes and its severe cardiovascular and renal complications.
Article number two. Cell-Free DNA Profiles End-Organ Injury and Predicts Outcomes in Advanced Heart Failure With Left Ventricular Assist Device Implantation. This study demonstrated that plasma cell-free DNA (cfDNA) accurately profiles end-organ injury and predicts outcomes in patients with advanced heart failure receiving left ventricular assist device (LVAD) implantation. The research identified cfDNA as a valuable biomarker for risk stratification following LVAD placement. It analyzed a multicenter prospective cohort of heart failure patients, including those with and without LVADs, to establish this predictive capability. This finding offers a novel approach to assess adverse events and improve risk management in this patient population.
Article number three. Immune Cell Type-Specific DNA Methylation Regions Associate With 24-Hour Blood Pressure Regulation in Black People. This study found that immune cell type-specific DNA methylation regions associate with 24-hour blood pressure regulation in Black people. Researchers established this connection by employing advanced deconvolution algorithms to analyze reduced representation bisulfite sequencing data. The study identified specific epigenetic markers within immune cells that play a role in blood pressure control. These findings highlight a novel mechanism linking immune cell epigenetics to hypertension risk within this specific population.
Article number four. Vascular and Neural Transcriptomics Reveal Stage-Dependent Pathways to Inflammation and Cognitive Dysfunction in a Rat Model of Hypertension. This study revealed stage-dependent vascular and neural transcriptomic pathways leading to inflammation and cognitive dysfunction in a rat model of hypertension. Researchers identified specific molecular and cellular mechanisms occurring at different stages of hypertension progression. The findings indicate distinct inflammatory and neural changes contributing to cerebral microvascular dysfunction and increased dementia risk. This research provides crucial insights into the complex pathogenesis of hypertension-related cognitive decline.
Article number five. C-C Chemokine Receptor 4 Deficiency Protects Against Abdominal Aortic Aneurysm Formation. This study found that C-C chemokine receptor 4 (CCR4) deficiency protects against abdominal aortic aneurysm (AAA) formation. Researchers observed this protective effect in hypercholesterolemic CCR4-deficient mice. The findings suggest that CCR4, predominantly expressed on T cells, plays a critical role in the dysregulated immune system driving chronic vascular inflammation and remodeling in AAA pathogenesis. This establishes CCR4 as a potential therapeutic target for preventing or treating abdominal aortic aneurysm.
Thank you for listening. Don’t forget to subscribe.
Keywords
abdominal aortic aneurysm, diabetic cardiomyopathy, immune cells, cardiorenal injury, Black people, neutrophil extracellular traps, hypertension, immune system, DNA methylation, neural transcriptomics, inflammation, blood pressure regulation, T cells, vascular transcriptomics, heart failure, vascular inflammation, peptidylarginine deiminase 4, biomarker, left ventricular assist device, cognitive dysfunction, end-organ injury, cell-free DNA, C-C chemokine receptor 4.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post Cell-Free DNA Predicts LVAD Outcomes 11/28/25 first appeared on Cardiology Today.
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