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Listen "Epigenetic Aging Predicts Cardiovascular Disease 11/28/25"
Episode Synopsis
Welcome to Cardiology Today – Recorded November 28, 2025. This episode summarizes 5 key cardiology studies on topics like cardiovascular disease and aspirin dosing. Key takeaway: Epigenetic Aging Predicts Cardiovascular Disease.
Article Links:
Article 1: Altitude-Related Differences in Biventricular Remodeling and the Clinical Profile of Pulmonary Hypertension: An Exploratory Cardiovascular Magnetic Resonance Study. (Journal of the American Heart Association)
Article 2: DNA Methylation Algorithms of Aging and Incident Cardiovascular Disease: A Prospective Cohort Study. (Journal of the American Heart Association)
Article 3: Aspirin Dosing for Secondary Prevention of Atherosclerotic Cardiovascular Disease in Chronic Obstructive Pulmonary Disease and Asthma: Insights From ADAPTABLE. (Journal of the American Heart Association)
Article 4: Intergenerational Socioeconomic Mobility and Cardiovascular Health Among Hispanic/Latino Youth and Caregivers Living in the United States. (Journal of the American Heart Association)
Article 5: Fontan-Associated Liver Disease: Trends Over Time and Relationship With Outcomes. (Journal of the American Heart Association)
Full episode page: https://podcast.explainheart.com/podcast/epigenetic-aging-predicts-cardiovascular-disease-11-28-25/
Featured Articles
Article 1: Altitude-Related Differences in Biventricular Remodeling and the Clinical Profile of Pulmonary Hypertension: An Exploratory Cardiovascular Magnetic Resonance Study.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294102
Summary: The study compared clinical profiles and biventricular remodeling in patients with pulmonary hypertension residing at high altitudes (2500 meters or greater) versus low altitudes. It revealed distinct patterns of cardiac adaptation and disease progression influenced by hypobaric hypoxia. Understanding these specific altitude-related differences is crucial for developing tailored management strategies. This research provides a foundation for improving outcomes for pulmonary hypertension patients in diverse geographical environments.
Article 2: DNA Methylation Algorithms of Aging and Incident Cardiovascular Disease: A Prospective Cohort Study.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294095
Summary: N. A. Methylation Algorithms of Aging and Incident Cardiovascular Disease: A Prospective Cohort Study. This prospective cohort study systematically compared 13 D. N. A. methylation algorithms to assess their relation to incident cardiovascular disease risk in 2112 older adults over a 6-year follow-up. The research clarified the differential utility of various D. N. A. methylation-based aging algorithms in predicting cardiovascular disease. This comparison provides important insights into the most effective epigenetic biomarkers for risk stratification. These findings support the integration of advanced aging algorithms into cardiovascular disease prediction models for older adults.
Article 3: Aspirin Dosing for Secondary Prevention of Atherosclerotic Cardiovascular Disease in Chronic Obstructive Pulmonary Disease and Asthma: Insights From ADAPTABLE.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294093
Summary: The ADAPTABLE trial provided specific evidence on the effectiveness and safety of two different aspirin doses for secondary prevention of atherosclerotic cardiovascular disease in patients with chronic obstructive pulmonary disease or asthma. This research demonstrates how optimal antiplatelet therapy differs for individuals with co-existing respiratory conditions, who carry increased cardiovascular risk. The findings inform tailored clinical decisions on aspirin dosing for secondary prevention. This study contributes to refining guideline recommendations for complex cardiovascular patient profiles.
Article 4: Intergenerational Socioeconomic Mobility and Cardiovascular Health Among Hispanic/Latino Youth and Caregivers Living in the United States.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294090
Summary: This study investigated the association between caregiver intergenerational socioeconomic mobility and cardiovascular health in both Hispanic/Latino youth and their caregivers. The research identified specific patterns in how socioeconomic background across generations influences cardiovascular health outcomes in this population. It further determined whether these associations are modified by youth’s sex and age, providing detailed insights into risk factors. Understanding these intergenerational and socioeconomic determinants is crucial for developing targeted public health interventions to improve cardiovascular health in Hispanic/Latino communities.
Article 5: Fontan-Associated Liver Disease: Trends Over Time and Relationship With Outcomes.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294084
Summary: This study described serial changes in liver function and their relationship with clinical outcomes in adult Fontan patients from 2014 to 2020. The research identified specific trends in liver enzymes and alpha-fetoprotein over time, demonstrating their utility in predicting adverse clinical outcomes. These findings provide crucial insights into the progression of Fontan-associated liver disease and its impact on long-term survival. Understanding these predictive markers is essential for early intervention and improved management strategies for this complex patient population.
Transcript
Today’s date is November 28, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Altitude-Related Differences in Biventricular Remodeling and the Clinical Profile of Pulmonary Hypertension: An Exploratory Cardiovascular Magnetic Resonance Study. The study compared clinical profiles and biventricular remodeling in patients with pulmonary hypertension residing at high altitudes (2500 meters or greater) versus low altitudes. It revealed distinct patterns of cardiac adaptation and disease progression influenced by hypobaric hypoxia. Understanding these specific altitude-related differences is crucial for developing tailored management strategies. This research provides a foundation for improving outcomes for pulmonary hypertension patients in diverse geographical environments.
Article number two. D. N. A. Methylation Algorithms of Aging and Incident Cardiovascular Disease: A Prospective Cohort Study. This prospective cohort study systematically compared 13 D. N. A. methylation algorithms to assess their relation to incident cardiovascular disease risk in 2112 older adults over a 6-year follow-up. The research clarified the differential utility of various D. N. A. methylation-based aging algorithms in predicting cardiovascular disease. This comparison provides important insights into the most effective epigenetic biomarkers for risk stratification. These findings support the integration of advanced aging algorithms into cardiovascular disease prediction models for older adults.
Article number three. Aspirin Dosing for Secondary Prevention of Atherosclerotic Cardiovascular Disease in Chronic Obstructive Pulmonary Disease and Asthma: Insights From ADAPTABLE. The ADAPTABLE trial provided specific evidence on the effectiveness and safety of two different aspirin doses for secondary prevention of atherosclerotic cardiovascular disease in patients with chronic obstructive pulmonary disease or asthma. This research demonstrates how optimal antiplatelet therapy differs for individuals with co-existing respiratory conditions, who carry increased cardiovascular risk. The findings inform tailored clinical decisions on aspirin dosing for secondary prevention. This study contributes to refining guideline recommendations for complex cardiovascular patient profiles.
Article number four. Intergenerational Socioeconomic Mobility and Cardiovascular Health Among Hispanic/Latino Youth and Caregivers Living in the United States. This study investigated the association between caregiver intergenerational socioeconomic mobility and cardiovascular health in both Hispanic/Latino youth and their caregivers. The research identified specific patterns in how socioeconomic background across generations influences cardiovascular health outcomes in this population. It further determined whether these associations are modified by youth’s sex and age, providing detailed insights into risk factors. Understanding these intergenerational and socioeconomic determinants is crucial for developing targeted public health interventions to improve cardiovascular health in Hispanic/Latino communities.
Article number five. Fontan-Associated Liver Disease: Trends Over Time and Relationship With Outcomes. This study described serial changes in liver function and their relationship with clinical outcomes in adult Fontan patients from 2014 to 2020. The research identified specific trends in liver enzymes and alpha-fetoprotein over time, demonstrating their utility in predicting adverse clinical outcomes. These findings provide crucial insights into the progression of Fontan-associated liver disease and its impact on long-term survival. Understanding these predictive markers is essential for early intervention and improved management strategies for this complex patient population.
Thank you for listening. Don’t forget to subscribe.
Keywords
cardiovascular disease, aspirin dosing, hypobaric hypoxia, asthma, youth health, socioeconomic mobility, aging algorithms, atherosclerotic cardiovascular disease, secondary prevention, chronic obstructive pulmonary disease, Hispanic/Latino, health disparities, adverse clinical outcomes, D. N. A. methylation, single ventricle palliation, Fontan circulation, pulmonary hypertension, risk prediction, cardiovascular health, high altitude, biventricular remodeling, liver function, Fontan-associated liver disease, cardiovascular magnetic resonance imaging, epigenetic biomarkers.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post Epigenetic Aging Predicts Cardiovascular Disease 11/28/25 first appeared on Cardiology Today.
Article Links:
Article 1: Altitude-Related Differences in Biventricular Remodeling and the Clinical Profile of Pulmonary Hypertension: An Exploratory Cardiovascular Magnetic Resonance Study. (Journal of the American Heart Association)
Article 2: DNA Methylation Algorithms of Aging and Incident Cardiovascular Disease: A Prospective Cohort Study. (Journal of the American Heart Association)
Article 3: Aspirin Dosing for Secondary Prevention of Atherosclerotic Cardiovascular Disease in Chronic Obstructive Pulmonary Disease and Asthma: Insights From ADAPTABLE. (Journal of the American Heart Association)
Article 4: Intergenerational Socioeconomic Mobility and Cardiovascular Health Among Hispanic/Latino Youth and Caregivers Living in the United States. (Journal of the American Heart Association)
Article 5: Fontan-Associated Liver Disease: Trends Over Time and Relationship With Outcomes. (Journal of the American Heart Association)
Full episode page: https://podcast.explainheart.com/podcast/epigenetic-aging-predicts-cardiovascular-disease-11-28-25/
Featured Articles
Article 1: Altitude-Related Differences in Biventricular Remodeling and the Clinical Profile of Pulmonary Hypertension: An Exploratory Cardiovascular Magnetic Resonance Study.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294102
Summary: The study compared clinical profiles and biventricular remodeling in patients with pulmonary hypertension residing at high altitudes (2500 meters or greater) versus low altitudes. It revealed distinct patterns of cardiac adaptation and disease progression influenced by hypobaric hypoxia. Understanding these specific altitude-related differences is crucial for developing tailored management strategies. This research provides a foundation for improving outcomes for pulmonary hypertension patients in diverse geographical environments.
Article 2: DNA Methylation Algorithms of Aging and Incident Cardiovascular Disease: A Prospective Cohort Study.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294095
Summary: N. A. Methylation Algorithms of Aging and Incident Cardiovascular Disease: A Prospective Cohort Study. This prospective cohort study systematically compared 13 D. N. A. methylation algorithms to assess their relation to incident cardiovascular disease risk in 2112 older adults over a 6-year follow-up. The research clarified the differential utility of various D. N. A. methylation-based aging algorithms in predicting cardiovascular disease. This comparison provides important insights into the most effective epigenetic biomarkers for risk stratification. These findings support the integration of advanced aging algorithms into cardiovascular disease prediction models for older adults.
Article 3: Aspirin Dosing for Secondary Prevention of Atherosclerotic Cardiovascular Disease in Chronic Obstructive Pulmonary Disease and Asthma: Insights From ADAPTABLE.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294093
Summary: The ADAPTABLE trial provided specific evidence on the effectiveness and safety of two different aspirin doses for secondary prevention of atherosclerotic cardiovascular disease in patients with chronic obstructive pulmonary disease or asthma. This research demonstrates how optimal antiplatelet therapy differs for individuals with co-existing respiratory conditions, who carry increased cardiovascular risk. The findings inform tailored clinical decisions on aspirin dosing for secondary prevention. This study contributes to refining guideline recommendations for complex cardiovascular patient profiles.
Article 4: Intergenerational Socioeconomic Mobility and Cardiovascular Health Among Hispanic/Latino Youth and Caregivers Living in the United States.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294090
Summary: This study investigated the association between caregiver intergenerational socioeconomic mobility and cardiovascular health in both Hispanic/Latino youth and their caregivers. The research identified specific patterns in how socioeconomic background across generations influences cardiovascular health outcomes in this population. It further determined whether these associations are modified by youth’s sex and age, providing detailed insights into risk factors. Understanding these intergenerational and socioeconomic determinants is crucial for developing targeted public health interventions to improve cardiovascular health in Hispanic/Latino communities.
Article 5: Fontan-Associated Liver Disease: Trends Over Time and Relationship With Outcomes.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294084
Summary: This study described serial changes in liver function and their relationship with clinical outcomes in adult Fontan patients from 2014 to 2020. The research identified specific trends in liver enzymes and alpha-fetoprotein over time, demonstrating their utility in predicting adverse clinical outcomes. These findings provide crucial insights into the progression of Fontan-associated liver disease and its impact on long-term survival. Understanding these predictive markers is essential for early intervention and improved management strategies for this complex patient population.
Transcript
Today’s date is November 28, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Altitude-Related Differences in Biventricular Remodeling and the Clinical Profile of Pulmonary Hypertension: An Exploratory Cardiovascular Magnetic Resonance Study. The study compared clinical profiles and biventricular remodeling in patients with pulmonary hypertension residing at high altitudes (2500 meters or greater) versus low altitudes. It revealed distinct patterns of cardiac adaptation and disease progression influenced by hypobaric hypoxia. Understanding these specific altitude-related differences is crucial for developing tailored management strategies. This research provides a foundation for improving outcomes for pulmonary hypertension patients in diverse geographical environments.
Article number two. D. N. A. Methylation Algorithms of Aging and Incident Cardiovascular Disease: A Prospective Cohort Study. This prospective cohort study systematically compared 13 D. N. A. methylation algorithms to assess their relation to incident cardiovascular disease risk in 2112 older adults over a 6-year follow-up. The research clarified the differential utility of various D. N. A. methylation-based aging algorithms in predicting cardiovascular disease. This comparison provides important insights into the most effective epigenetic biomarkers for risk stratification. These findings support the integration of advanced aging algorithms into cardiovascular disease prediction models for older adults.
Article number three. Aspirin Dosing for Secondary Prevention of Atherosclerotic Cardiovascular Disease in Chronic Obstructive Pulmonary Disease and Asthma: Insights From ADAPTABLE. The ADAPTABLE trial provided specific evidence on the effectiveness and safety of two different aspirin doses for secondary prevention of atherosclerotic cardiovascular disease in patients with chronic obstructive pulmonary disease or asthma. This research demonstrates how optimal antiplatelet therapy differs for individuals with co-existing respiratory conditions, who carry increased cardiovascular risk. The findings inform tailored clinical decisions on aspirin dosing for secondary prevention. This study contributes to refining guideline recommendations for complex cardiovascular patient profiles.
Article number four. Intergenerational Socioeconomic Mobility and Cardiovascular Health Among Hispanic/Latino Youth and Caregivers Living in the United States. This study investigated the association between caregiver intergenerational socioeconomic mobility and cardiovascular health in both Hispanic/Latino youth and their caregivers. The research identified specific patterns in how socioeconomic background across generations influences cardiovascular health outcomes in this population. It further determined whether these associations are modified by youth’s sex and age, providing detailed insights into risk factors. Understanding these intergenerational and socioeconomic determinants is crucial for developing targeted public health interventions to improve cardiovascular health in Hispanic/Latino communities.
Article number five. Fontan-Associated Liver Disease: Trends Over Time and Relationship With Outcomes. This study described serial changes in liver function and their relationship with clinical outcomes in adult Fontan patients from 2014 to 2020. The research identified specific trends in liver enzymes and alpha-fetoprotein over time, demonstrating their utility in predicting adverse clinical outcomes. These findings provide crucial insights into the progression of Fontan-associated liver disease and its impact on long-term survival. Understanding these predictive markers is essential for early intervention and improved management strategies for this complex patient population.
Thank you for listening. Don’t forget to subscribe.
Keywords
cardiovascular disease, aspirin dosing, hypobaric hypoxia, asthma, youth health, socioeconomic mobility, aging algorithms, atherosclerotic cardiovascular disease, secondary prevention, chronic obstructive pulmonary disease, Hispanic/Latino, health disparities, adverse clinical outcomes, D. N. A. methylation, single ventricle palliation, Fontan circulation, pulmonary hypertension, risk prediction, cardiovascular health, high altitude, biventricular remodeling, liver function, Fontan-associated liver disease, cardiovascular magnetic resonance imaging, epigenetic biomarkers.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post Epigenetic Aging Predicts Cardiovascular Disease 11/28/25 first appeared on Cardiology Today.
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