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Listen "Cardiac Amyloidosis Survival Up Over Time. 11/28/25"
Episode Synopsis
Welcome to Cardiology Today – Recorded November 28, 2025. This episode summarizes 5 key cardiology studies on topics like high-sensitivity troponin T and atherosclerotic cardiovascular disease. Key takeaway: Cardiac Amyloidosis Survival Up Over Time..
Article Links:
Article 1: A polygenic risk score for peripheral artery disease and major adverse limb events. (European heart journal)
Article 2: Small RNA Sequencing of Human Urinary Extracellular Vesicles Reveals Association of High-Sodium Diet With Renal Proinflammatory Pathways. (Journal of the American Heart Association)
Article 3: Diagnostic and Prognostic Value of High-Sensitivity Troponin T for Cardiovascular Outcomes in Patients Receiving Immune Checkpoint Inhibitor Therapy. (Journal of the American Heart Association)
Article 4: Association Between Monoclonal Gammopathy of Undetermined Significance and Cardiovascular Disease Risk: A Veterans Health Administration Study. (Journal of the American Heart Association)
Article 5: Changing Patterns of Diagnosis and Survival in Transthyretin Cardiac Amyloidosis: A Multicenter Cohort Study. (Journal of the American Heart Association)
Full episode page: https://podcast.explainheart.com/podcast/cardiac-amyloidosis-survival-up-over-time-11-28-25/
Featured Articles
Article 1: A polygenic risk score for peripheral artery disease and major adverse limb events.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41312852
Summary: Large-scale genome-wide association studies identified common genetic variants that predict peripheral artery disease risk. This study assessed a specific polygenic risk score for its association with peripheral artery disease and major adverse limb events, independent of other clinical risk factors. The research involved a genetic analysis using individual patient data pooled from six Thrombolysis in Myocardial Infarction trials. This approach demonstrates the method for integrating genetic predisposition into risk stratification for limb-related cardiovascular outcomes.
Article 2: Small RNA Sequencing of Human Urinary Extracellular Vesicles Reveals Association of High-Sodium Diet With Renal Proinflammatory Pathways.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294135
Summary: Small RNA sequencing of human urinary extracellular vesicles revealed an association between a high-sodium diet and renal proinflammatory pathways. This study demonstrated that high sodium intake is linked to mechanisms beyond hemodynamic changes, including endothelial dysfunction and oxidative stress. Researchers observed the induction of a proinflammatory milieu in the kidneys. The findings highlight how dietary sodium modulation impacts renal pathophysiology at a molecular level in normotensive subjects.
Article 3: Diagnostic and Prognostic Value of High-Sensitivity Troponin T for Cardiovascular Outcomes in Patients Receiving Immune Checkpoint Inhibitor Therapy.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294120
Summary: This study established the diagnostic and prognostic value of high-sensitivity troponin T for cardiovascular outcomes in patients receiving immune-checkpoint inhibitor therapy. Immune-checkpoint inhibitors are known to be associated with adverse cardiac events, with troponin elevation already a diagnostic criterion for immune-checkpoint inhibitor-related myocarditis and myocardial infarction. The research documented additional causes of troponin elevation and their observed outcomes, including cardiac death and heart failure, in these patients. This comprehensive analysis clarified the clinical utility of high-sensitivity troponin T measurements across a broad spectrum of cardiac issues in this specific patient group.
Article 4: Association Between Monoclonal Gammopathy of Undetermined Significance and Cardiovascular Disease Risk: A Veterans Health Administration Study.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294118
Summary: This Veterans Health Administration study found a significant association between monoclonal gammopathy of undetermined significance and incident cardiovascular disease risk. Monoclonal gammopathy of undetermined significance was already known to be associated with an increased cardiovascular disease risk. The research demonstrated that monoclonal gammopathy of undetermined significance status provided additional prognostic information beyond traditional atherosclerotic cardiovascular disease risk calculation. This finding highlights the crucial role of considering monoclonal gammopathy of undetermined significance in comprehensive cardiovascular risk assessment.
Article 5: Changing Patterns of Diagnosis and Survival in Transthyretin Cardiac Amyloidosis: A Multicenter Cohort Study.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294107
Summary: Diagnostic rates of transthyretin cardiac amyloidosis have increased due to growing awareness, noninvasive diagnoses, and treatments improving morbidity and mortality. This multicenter study revealed significant changes in baseline characteristics and survival patterns for transthyretin cardiac amyloidosis patients in the United States. The research demonstrated improved mortality outcomes when comparing distinct eras: pre-2010, 2010-2013, 2014-2017, and 2018-2021. These findings highlight the positive impact of diagnostic and therapeutic advancements on patient prognosis over time.
Transcript
Today’s date is November 28, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. A polygenic risk score for peripheral artery disease and major adverse limb events. Large-scale genome-wide association studies identified common genetic variants that predict peripheral artery disease risk. This study assessed a specific polygenic risk score for its association with peripheral artery disease and major adverse limb events, independent of other clinical risk factors. The research involved a genetic analysis using individual patient data pooled from six Thrombolysis in Myocardial Infarction trials. This approach demonstrates the method for integrating genetic predisposition into risk stratification for limb-related cardiovascular outcomes.
Article number two. Small RNA Sequencing of Human Urinary Extracellular Vesicles Reveals Association of High-Sodium Diet With Renal Proinflammatory Pathways. Small RNA sequencing of human urinary extracellular vesicles revealed an association between a high-sodium diet and renal proinflammatory pathways. This study demonstrated that high sodium intake is linked to mechanisms beyond hemodynamic changes, including endothelial dysfunction and oxidative stress. Researchers observed the induction of a proinflammatory milieu in the kidneys. The findings highlight how dietary sodium modulation impacts renal pathophysiology at a molecular level in normotensive subjects.
Article number three. Diagnostic and Prognostic Value of High-Sensitivity Troponin T for Cardiovascular Outcomes in Patients Receiving Immune Checkpoint Inhibitor Therapy. This study established the diagnostic and prognostic value of high-sensitivity troponin T for cardiovascular outcomes in patients receiving immune-checkpoint inhibitor therapy. Immune-checkpoint inhibitors are known to be associated with adverse cardiac events, with troponin elevation already a diagnostic criterion for immune-checkpoint inhibitor-related myocarditis and myocardial infarction. The research documented additional causes of troponin elevation and their observed outcomes, including cardiac death and heart failure, in these patients. This comprehensive analysis clarified the clinical utility of high-sensitivity troponin T measurements across a broad spectrum of cardiac issues in this specific patient group.
Article number four. Association Between Monoclonal Gammopathy of Undetermined Significance and Cardiovascular Disease Risk: A Veterans Health Administration Study. This Veterans Health Administration study found a significant association between monoclonal gammopathy of undetermined significance and incident cardiovascular disease risk. Monoclonal gammopathy of undetermined significance was already known to be associated with an increased cardiovascular disease risk. The research demonstrated that monoclonal gammopathy of undetermined significance status provided additional prognostic information beyond traditional atherosclerotic cardiovascular disease risk calculation. This finding highlights the crucial role of considering monoclonal gammopathy of undetermined significance in comprehensive cardiovascular risk assessment.
Article number five. Changing Patterns of Diagnosis and Survival in Transthyretin Cardiac Amyloidosis: A Multicenter Cohort Study. Diagnostic rates of transthyretin cardiac amyloidosis have increased due to growing awareness, noninvasive diagnoses, and treatments improving morbidity and mortality. This multicenter study revealed significant changes in baseline characteristics and survival patterns for transthyretin cardiac amyloidosis patients in the United States. The research demonstrated improved mortality outcomes when comparing distinct eras: pre-2010, 2010-2013, 2014-2017, and 2018-2021. These findings highlight the positive impact of diagnostic and therapeutic advancements on patient prognosis over time.
Thank you for listening. Don’t forget to subscribe.
Keywords
high-sensitivity troponin T, atherosclerotic cardiovascular disease, cardiometabolic disease, endothelial dysfunction, peripheral artery disease, renal inflammation, heart failure, myocarditis, genetic variants, cardiovascular disease, survival trends, prognostic value, high sodium intake, immune-checkpoint inhibitors, extracellular vesicles, small RNA sequencing, diagnostic patterns, cardiac death, major adverse limb events, noninvasive diagnosis, risk assessment, polygenic risk score, monoclonal gammopathy of undetermined significance, transthyretin cardiac amyloidosis, heart failure therapies.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post Cardiac Amyloidosis Survival Up Over Time. 11/28/25 first appeared on Cardiology Today.
Article Links:
Article 1: A polygenic risk score for peripheral artery disease and major adverse limb events. (European heart journal)
Article 2: Small RNA Sequencing of Human Urinary Extracellular Vesicles Reveals Association of High-Sodium Diet With Renal Proinflammatory Pathways. (Journal of the American Heart Association)
Article 3: Diagnostic and Prognostic Value of High-Sensitivity Troponin T for Cardiovascular Outcomes in Patients Receiving Immune Checkpoint Inhibitor Therapy. (Journal of the American Heart Association)
Article 4: Association Between Monoclonal Gammopathy of Undetermined Significance and Cardiovascular Disease Risk: A Veterans Health Administration Study. (Journal of the American Heart Association)
Article 5: Changing Patterns of Diagnosis and Survival in Transthyretin Cardiac Amyloidosis: A Multicenter Cohort Study. (Journal of the American Heart Association)
Full episode page: https://podcast.explainheart.com/podcast/cardiac-amyloidosis-survival-up-over-time-11-28-25/
Featured Articles
Article 1: A polygenic risk score for peripheral artery disease and major adverse limb events.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41312852
Summary: Large-scale genome-wide association studies identified common genetic variants that predict peripheral artery disease risk. This study assessed a specific polygenic risk score for its association with peripheral artery disease and major adverse limb events, independent of other clinical risk factors. The research involved a genetic analysis using individual patient data pooled from six Thrombolysis in Myocardial Infarction trials. This approach demonstrates the method for integrating genetic predisposition into risk stratification for limb-related cardiovascular outcomes.
Article 2: Small RNA Sequencing of Human Urinary Extracellular Vesicles Reveals Association of High-Sodium Diet With Renal Proinflammatory Pathways.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294135
Summary: Small RNA sequencing of human urinary extracellular vesicles revealed an association between a high-sodium diet and renal proinflammatory pathways. This study demonstrated that high sodium intake is linked to mechanisms beyond hemodynamic changes, including endothelial dysfunction and oxidative stress. Researchers observed the induction of a proinflammatory milieu in the kidneys. The findings highlight how dietary sodium modulation impacts renal pathophysiology at a molecular level in normotensive subjects.
Article 3: Diagnostic and Prognostic Value of High-Sensitivity Troponin T for Cardiovascular Outcomes in Patients Receiving Immune Checkpoint Inhibitor Therapy.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294120
Summary: This study established the diagnostic and prognostic value of high-sensitivity troponin T for cardiovascular outcomes in patients receiving immune-checkpoint inhibitor therapy. Immune-checkpoint inhibitors are known to be associated with adverse cardiac events, with troponin elevation already a diagnostic criterion for immune-checkpoint inhibitor-related myocarditis and myocardial infarction. The research documented additional causes of troponin elevation and their observed outcomes, including cardiac death and heart failure, in these patients. This comprehensive analysis clarified the clinical utility of high-sensitivity troponin T measurements across a broad spectrum of cardiac issues in this specific patient group.
Article 4: Association Between Monoclonal Gammopathy of Undetermined Significance and Cardiovascular Disease Risk: A Veterans Health Administration Study.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294118
Summary: This Veterans Health Administration study found a significant association between monoclonal gammopathy of undetermined significance and incident cardiovascular disease risk. Monoclonal gammopathy of undetermined significance was already known to be associated with an increased cardiovascular disease risk. The research demonstrated that monoclonal gammopathy of undetermined significance status provided additional prognostic information beyond traditional atherosclerotic cardiovascular disease risk calculation. This finding highlights the crucial role of considering monoclonal gammopathy of undetermined significance in comprehensive cardiovascular risk assessment.
Article 5: Changing Patterns of Diagnosis and Survival in Transthyretin Cardiac Amyloidosis: A Multicenter Cohort Study.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294107
Summary: Diagnostic rates of transthyretin cardiac amyloidosis have increased due to growing awareness, noninvasive diagnoses, and treatments improving morbidity and mortality. This multicenter study revealed significant changes in baseline characteristics and survival patterns for transthyretin cardiac amyloidosis patients in the United States. The research demonstrated improved mortality outcomes when comparing distinct eras: pre-2010, 2010-2013, 2014-2017, and 2018-2021. These findings highlight the positive impact of diagnostic and therapeutic advancements on patient prognosis over time.
Transcript
Today’s date is November 28, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. A polygenic risk score for peripheral artery disease and major adverse limb events. Large-scale genome-wide association studies identified common genetic variants that predict peripheral artery disease risk. This study assessed a specific polygenic risk score for its association with peripheral artery disease and major adverse limb events, independent of other clinical risk factors. The research involved a genetic analysis using individual patient data pooled from six Thrombolysis in Myocardial Infarction trials. This approach demonstrates the method for integrating genetic predisposition into risk stratification for limb-related cardiovascular outcomes.
Article number two. Small RNA Sequencing of Human Urinary Extracellular Vesicles Reveals Association of High-Sodium Diet With Renal Proinflammatory Pathways. Small RNA sequencing of human urinary extracellular vesicles revealed an association between a high-sodium diet and renal proinflammatory pathways. This study demonstrated that high sodium intake is linked to mechanisms beyond hemodynamic changes, including endothelial dysfunction and oxidative stress. Researchers observed the induction of a proinflammatory milieu in the kidneys. The findings highlight how dietary sodium modulation impacts renal pathophysiology at a molecular level in normotensive subjects.
Article number three. Diagnostic and Prognostic Value of High-Sensitivity Troponin T for Cardiovascular Outcomes in Patients Receiving Immune Checkpoint Inhibitor Therapy. This study established the diagnostic and prognostic value of high-sensitivity troponin T for cardiovascular outcomes in patients receiving immune-checkpoint inhibitor therapy. Immune-checkpoint inhibitors are known to be associated with adverse cardiac events, with troponin elevation already a diagnostic criterion for immune-checkpoint inhibitor-related myocarditis and myocardial infarction. The research documented additional causes of troponin elevation and their observed outcomes, including cardiac death and heart failure, in these patients. This comprehensive analysis clarified the clinical utility of high-sensitivity troponin T measurements across a broad spectrum of cardiac issues in this specific patient group.
Article number four. Association Between Monoclonal Gammopathy of Undetermined Significance and Cardiovascular Disease Risk: A Veterans Health Administration Study. This Veterans Health Administration study found a significant association between monoclonal gammopathy of undetermined significance and incident cardiovascular disease risk. Monoclonal gammopathy of undetermined significance was already known to be associated with an increased cardiovascular disease risk. The research demonstrated that monoclonal gammopathy of undetermined significance status provided additional prognostic information beyond traditional atherosclerotic cardiovascular disease risk calculation. This finding highlights the crucial role of considering monoclonal gammopathy of undetermined significance in comprehensive cardiovascular risk assessment.
Article number five. Changing Patterns of Diagnosis and Survival in Transthyretin Cardiac Amyloidosis: A Multicenter Cohort Study. Diagnostic rates of transthyretin cardiac amyloidosis have increased due to growing awareness, noninvasive diagnoses, and treatments improving morbidity and mortality. This multicenter study revealed significant changes in baseline characteristics and survival patterns for transthyretin cardiac amyloidosis patients in the United States. The research demonstrated improved mortality outcomes when comparing distinct eras: pre-2010, 2010-2013, 2014-2017, and 2018-2021. These findings highlight the positive impact of diagnostic and therapeutic advancements on patient prognosis over time.
Thank you for listening. Don’t forget to subscribe.
Keywords
high-sensitivity troponin T, atherosclerotic cardiovascular disease, cardiometabolic disease, endothelial dysfunction, peripheral artery disease, renal inflammation, heart failure, myocarditis, genetic variants, cardiovascular disease, survival trends, prognostic value, high sodium intake, immune-checkpoint inhibitors, extracellular vesicles, small RNA sequencing, diagnostic patterns, cardiac death, major adverse limb events, noninvasive diagnosis, risk assessment, polygenic risk score, monoclonal gammopathy of undetermined significance, transthyretin cardiac amyloidosis, heart failure therapies.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post Cardiac Amyloidosis Survival Up Over Time. 11/28/25 first appeared on Cardiology Today.
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