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Listen "Aspirin Elimination Safe for HeartMate 3 LVADs 11/28/25"
Episode Synopsis
Welcome to Cardiology Today – Recorded November 28, 2025. This episode summarizes 5 key cardiology studies on topics like Atherosclerosis and Proinflammatory cytokines. Key takeaway: Aspirin Elimination Safe for HeartMate 3 LVADs.
Article Links:
Article 1: Impact of Atrial Fibrillation, Diabetes Mellitus and Obesity on Outcomes with Aspirin Avoidance and Hemocompatibility with a Left Ventricular Assist Device: An analysis from the ARIES-HM3 Trial. (Journal of cardiac failure)
Article 2: Immune Checkpoint Inhibitors, Atherosclerotic Cardiovascular Events, and Plaque Progression Among Women With Cancer. (Journal of the American Heart Association)
Article 3: Loss of Endothelial YAP/TAZ Reduces the Size of Chronic Stroke Lesions and Alters the Endothelial Environment. (Journal of the American Heart Association)
Article 4: Detrimental Effect of Plasma From Patients With Severe Aortic Stenosis on Valvular Endothelial Cells: Role of Proinflammatory Cytokines and Factor Xa. (Journal of the American Heart Association)
Article 5: Intracellular Osteopontin of Macrophages Promotes Carotid Plaques Formation by Inducing Foam Cells and Releasing Proinflammatory Cytokines. (Journal of the American Heart Association)
Full episode page: https://podcast.explainheart.com/podcast/aspirin-elimination-safe-for-heartmate-3-lvads-11-28-25/
Featured Articles
Article 1: Impact of Atrial Fibrillation, Diabetes Mellitus and Obesity on Outcomes with Aspirin Avoidance and Hemocompatibility with a Left Ventricular Assist Device: An analysis from the ARIES-HM3 Trial.
Journal: Journal of cardiac failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41308860
Summary: The ARIES-HM3 trial confirmed the safety and effectiveness of aspirin elimination from the antithrombotic regimen following HeartMate 3 Left Ventricular Assist Device implantation. This specific analysis determined the interaction of atrial fibrillation, diabetes mellitus, and obesity with aspirin elimination regarding hemocompatibility-related adverse events at one year post-implant. The trial randomized patients with a HeartMate 3 Left Ventricular Assist Device to receive aspirin or placebo. This investigation informs personalized antithrombotic management for patients with these common comorbidities.
Article 2: Immune Checkpoint Inhibitors, Atherosclerotic Cardiovascular Events, and Plaque Progression Among Women With Cancer.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294143
Summary: Immune checkpoint inhibitors are associated with a three-fold risk of atherosclerotic cardiovascular disease. This single-center retrospective study demonstrated factors associated with atherosclerotic cardiovascular disease in women following immune checkpoint inhibitor therapy. The investigation also characterized plaque progression specifically among women with cancer receiving these treatments.
Article 3: Loss of Endothelial YAP/TAZ Reduces the Size of Chronic Stroke Lesions and Alters the Endothelial Environment.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294142
Summary: The loss of endothelial Yes Associated Protein 1 and WW Domain Containing Transcription Regulator 1 reduced the size of chronic stroke lesions and altered the endothelial environment. This study revealed that brain endothelial cells play a critical role in determining stroke outcomes. The findings indicate a potential therapeutic target for ischemic stroke, a leading cause of morbidity and mortality.
Article 4: Detrimental Effect of Plasma From Patients With Severe Aortic Stenosis on Valvular Endothelial Cells: Role of Proinflammatory Cytokines and Factor Xa.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294140
Summary: Plasma from patients with severe aortic stenosis had a detrimental effect on valvular endothelial cells. This effect included inducing oxidative stress and contributing to valvular endothelial cell dysfunction. Proinflammatory cytokines, such as interleukin and tumor necrosis factor alpha, along with Factor Xa, were found to mediate these harmful processes. The study identified key plasma components contributing to aortic stenosis progression.
Article 5: Intracellular Osteopontin of Macrophages Promotes Carotid Plaques Formation by Inducing Foam Cells and Releasing Proinflammatory Cytokines.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294139
Summary: Intracellular osteopontin within macrophages promotes carotid plaque formation by inducing foam cell formation and releasing proinflammatory cytokines. Single cell R. N. A. sequencing of human carotid plaques identified major cell types and a key cell cluster involved in plaque development. In vitro experiments further confirmed the role of osteopontin in macrophages in this process.
Transcript
Today’s date is November 28, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Impact of Atrial Fibrillation, Diabetes Mellitus and Obesity on Outcomes with Aspirin Avoidance and Hemocompatibility with a Left Ventricular Assist Device: An analysis from the ARIES-HM3 Trial. The ARIES-HM3 trial confirmed the safety and effectiveness of aspirin elimination from the antithrombotic regimen following HeartMate 3 Left Ventricular Assist Device implantation. This specific analysis determined the interaction of atrial fibrillation, diabetes mellitus, and obesity with aspirin elimination regarding hemocompatibility-related adverse events at one year post-implant. The trial randomized patients with a HeartMate 3 Left Ventricular Assist Device to receive aspirin or placebo. This investigation informs personalized antithrombotic management for patients with these common comorbidities.
Article number two. Immune Checkpoint Inhibitors, Atherosclerotic Cardiovascular Events, and Plaque Progression Among Women With Cancer. Immune checkpoint inhibitors are associated with a three-fold risk of atherosclerotic cardiovascular disease. This single-center retrospective study demonstrated factors associated with atherosclerotic cardiovascular disease in women following immune checkpoint inhibitor therapy. The investigation also characterized plaque progression specifically among women with cancer receiving these treatments.
Article number three. Loss of Endothelial YAP/TAZ Reduces the Size of Chronic Stroke Lesions and Alters the Endothelial Environment. The loss of endothelial Yes Associated Protein 1 and WW Domain Containing Transcription Regulator 1 reduced the size of chronic stroke lesions and altered the endothelial environment. This study revealed that brain endothelial cells play a critical role in determining stroke outcomes. The findings indicate a potential therapeutic target for ischemic stroke, a leading cause of morbidity and mortality.
Article number four. Detrimental Effect of Plasma From Patients With Severe Aortic Stenosis on Valvular Endothelial Cells: Role of Proinflammatory Cytokines and Factor Xa. Plasma from patients with severe aortic stenosis had a detrimental effect on valvular endothelial cells. This effect included inducing oxidative stress and contributing to valvular endothelial cell dysfunction. Proinflammatory cytokines, such as interleukin and tumor necrosis factor alpha, along with Factor Xa, were found to mediate these harmful processes. The study identified key plasma components contributing to aortic stenosis progression.
Article number five. Intracellular Osteopontin of Macrophages Promotes Carotid Plaques Formation by Inducing Foam Cells and Releasing Proinflammatory Cytokines. Intracellular osteopontin within macrophages promotes carotid plaque formation by inducing foam cell formation and releasing proinflammatory cytokines. Single cell R. N. A. sequencing of human carotid plaques identified major cell types and a key cell cluster involved in plaque development. In vitro experiments further confirmed the role of osteopontin in macrophages in this process.
Thank you for listening. Don’t forget to subscribe.
Keywords
Atherosclerosis, Proinflammatory cytokines, Cancer, Factor Xa, Endothelial cells, Women, Yes Associated Protein 1, Stroke lesions, Diabetes mellitus, Immune Checkpoint Inhibitors, Atherosclerotic cardiovascular disease, Aortic stenosis, Aspirin elimination, Plaque progression, Carotid plaque, Oxidative stress, Ischemic stroke, WW Domain Containing Transcription Regulator 1, Antithrombotic regimen, Osteopontin, Atrial fibrillation, Valvular endothelial cells, Macrophages, Foam cells, Left Ventricular Assist Device.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post Aspirin Elimination Safe for HeartMate 3 LVADs 11/28/25 first appeared on Cardiology Today.
Article Links:
Article 1: Impact of Atrial Fibrillation, Diabetes Mellitus and Obesity on Outcomes with Aspirin Avoidance and Hemocompatibility with a Left Ventricular Assist Device: An analysis from the ARIES-HM3 Trial. (Journal of cardiac failure)
Article 2: Immune Checkpoint Inhibitors, Atherosclerotic Cardiovascular Events, and Plaque Progression Among Women With Cancer. (Journal of the American Heart Association)
Article 3: Loss of Endothelial YAP/TAZ Reduces the Size of Chronic Stroke Lesions and Alters the Endothelial Environment. (Journal of the American Heart Association)
Article 4: Detrimental Effect of Plasma From Patients With Severe Aortic Stenosis on Valvular Endothelial Cells: Role of Proinflammatory Cytokines and Factor Xa. (Journal of the American Heart Association)
Article 5: Intracellular Osteopontin of Macrophages Promotes Carotid Plaques Formation by Inducing Foam Cells and Releasing Proinflammatory Cytokines. (Journal of the American Heart Association)
Full episode page: https://podcast.explainheart.com/podcast/aspirin-elimination-safe-for-heartmate-3-lvads-11-28-25/
Featured Articles
Article 1: Impact of Atrial Fibrillation, Diabetes Mellitus and Obesity on Outcomes with Aspirin Avoidance and Hemocompatibility with a Left Ventricular Assist Device: An analysis from the ARIES-HM3 Trial.
Journal: Journal of cardiac failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41308860
Summary: The ARIES-HM3 trial confirmed the safety and effectiveness of aspirin elimination from the antithrombotic regimen following HeartMate 3 Left Ventricular Assist Device implantation. This specific analysis determined the interaction of atrial fibrillation, diabetes mellitus, and obesity with aspirin elimination regarding hemocompatibility-related adverse events at one year post-implant. The trial randomized patients with a HeartMate 3 Left Ventricular Assist Device to receive aspirin or placebo. This investigation informs personalized antithrombotic management for patients with these common comorbidities.
Article 2: Immune Checkpoint Inhibitors, Atherosclerotic Cardiovascular Events, and Plaque Progression Among Women With Cancer.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294143
Summary: Immune checkpoint inhibitors are associated with a three-fold risk of atherosclerotic cardiovascular disease. This single-center retrospective study demonstrated factors associated with atherosclerotic cardiovascular disease in women following immune checkpoint inhibitor therapy. The investigation also characterized plaque progression specifically among women with cancer receiving these treatments.
Article 3: Loss of Endothelial YAP/TAZ Reduces the Size of Chronic Stroke Lesions and Alters the Endothelial Environment.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294142
Summary: The loss of endothelial Yes Associated Protein 1 and WW Domain Containing Transcription Regulator 1 reduced the size of chronic stroke lesions and altered the endothelial environment. This study revealed that brain endothelial cells play a critical role in determining stroke outcomes. The findings indicate a potential therapeutic target for ischemic stroke, a leading cause of morbidity and mortality.
Article 4: Detrimental Effect of Plasma From Patients With Severe Aortic Stenosis on Valvular Endothelial Cells: Role of Proinflammatory Cytokines and Factor Xa.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294140
Summary: Plasma from patients with severe aortic stenosis had a detrimental effect on valvular endothelial cells. This effect included inducing oxidative stress and contributing to valvular endothelial cell dysfunction. Proinflammatory cytokines, such as interleukin and tumor necrosis factor alpha, along with Factor Xa, were found to mediate these harmful processes. The study identified key plasma components contributing to aortic stenosis progression.
Article 5: Intracellular Osteopontin of Macrophages Promotes Carotid Plaques Formation by Inducing Foam Cells and Releasing Proinflammatory Cytokines.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294139
Summary: Intracellular osteopontin within macrophages promotes carotid plaque formation by inducing foam cell formation and releasing proinflammatory cytokines. Single cell R. N. A. sequencing of human carotid plaques identified major cell types and a key cell cluster involved in plaque development. In vitro experiments further confirmed the role of osteopontin in macrophages in this process.
Transcript
Today’s date is November 28, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Impact of Atrial Fibrillation, Diabetes Mellitus and Obesity on Outcomes with Aspirin Avoidance and Hemocompatibility with a Left Ventricular Assist Device: An analysis from the ARIES-HM3 Trial. The ARIES-HM3 trial confirmed the safety and effectiveness of aspirin elimination from the antithrombotic regimen following HeartMate 3 Left Ventricular Assist Device implantation. This specific analysis determined the interaction of atrial fibrillation, diabetes mellitus, and obesity with aspirin elimination regarding hemocompatibility-related adverse events at one year post-implant. The trial randomized patients with a HeartMate 3 Left Ventricular Assist Device to receive aspirin or placebo. This investigation informs personalized antithrombotic management for patients with these common comorbidities.
Article number two. Immune Checkpoint Inhibitors, Atherosclerotic Cardiovascular Events, and Plaque Progression Among Women With Cancer. Immune checkpoint inhibitors are associated with a three-fold risk of atherosclerotic cardiovascular disease. This single-center retrospective study demonstrated factors associated with atherosclerotic cardiovascular disease in women following immune checkpoint inhibitor therapy. The investigation also characterized plaque progression specifically among women with cancer receiving these treatments.
Article number three. Loss of Endothelial YAP/TAZ Reduces the Size of Chronic Stroke Lesions and Alters the Endothelial Environment. The loss of endothelial Yes Associated Protein 1 and WW Domain Containing Transcription Regulator 1 reduced the size of chronic stroke lesions and altered the endothelial environment. This study revealed that brain endothelial cells play a critical role in determining stroke outcomes. The findings indicate a potential therapeutic target for ischemic stroke, a leading cause of morbidity and mortality.
Article number four. Detrimental Effect of Plasma From Patients With Severe Aortic Stenosis on Valvular Endothelial Cells: Role of Proinflammatory Cytokines and Factor Xa. Plasma from patients with severe aortic stenosis had a detrimental effect on valvular endothelial cells. This effect included inducing oxidative stress and contributing to valvular endothelial cell dysfunction. Proinflammatory cytokines, such as interleukin and tumor necrosis factor alpha, along with Factor Xa, were found to mediate these harmful processes. The study identified key plasma components contributing to aortic stenosis progression.
Article number five. Intracellular Osteopontin of Macrophages Promotes Carotid Plaques Formation by Inducing Foam Cells and Releasing Proinflammatory Cytokines. Intracellular osteopontin within macrophages promotes carotid plaque formation by inducing foam cell formation and releasing proinflammatory cytokines. Single cell R. N. A. sequencing of human carotid plaques identified major cell types and a key cell cluster involved in plaque development. In vitro experiments further confirmed the role of osteopontin in macrophages in this process.
Thank you for listening. Don’t forget to subscribe.
Keywords
Atherosclerosis, Proinflammatory cytokines, Cancer, Factor Xa, Endothelial cells, Women, Yes Associated Protein 1, Stroke lesions, Diabetes mellitus, Immune Checkpoint Inhibitors, Atherosclerotic cardiovascular disease, Aortic stenosis, Aspirin elimination, Plaque progression, Carotid plaque, Oxidative stress, Ischemic stroke, WW Domain Containing Transcription Regulator 1, Antithrombotic regimen, Osteopontin, Atrial fibrillation, Valvular endothelial cells, Macrophages, Foam cells, Left Ventricular Assist Device.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post Aspirin Elimination Safe for HeartMate 3 LVADs 11/28/25 first appeared on Cardiology Today.
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