Welcome to What's it Worth! Join Dr. Diana Langworthy, Garrison Griest, and Nathan Uk for our first episode where we go down the WATERFALL and take a deep dive into the details of a prospective, open-label trial comparing aggressive and moderate fluid resuscitation strategies in the initial treatment of acute pancreatitis. Key Points Aggressive fluid resuscitation has historically been preferred in the treatment of acute pancreatitis There is conflicting evidence as to whether aggressive or moderate resuscitation is the safest and most effective approach in patients with acute pancreatitis Statistical power is an important concept to understand to determine whether the study has the means to reject the null hypothesis The trial was stopped early due to safety concerns with the aggressive resuscitation arm - what does this mean for efficacy? -> Tune in to find out! Episode References de-Madaria E, Buxbaum JL, Maisonneuve P, et al. Aggressive or moderate fluid resuscitation in acute pancreatitis. N Engl J Med 2022;387:989-1000. [WATERFALL study] Banks PA, Bollen TL, Dervenis C, et al. Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus. Gut 2013;62(1):102-111. Jones SR, Carley S, Harrison M. An introduction to power and sample size estimation. Emerg Med J 2003;20:453-458.  Contact Information Podcast email: [email protected] Host Information:  Dr. Diana R. Langworthy, PharmD, BCPS Clinical Associate Professor, University of Minnesota College of Pharmacy Clinical Pharmacist-Inpatient Internal Medicine, M Health Fairview East Bank Hospital

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