Vincent travels to the University of Texas in Austin to speak with speak with Jason McLellan about his career and his research on the SARS-CoV-2 spike protein, including the effect of adding two proline residues, its effect on other viral spike glycoproteins, and general approaches to vaccine design. Hosts: Vincent Racaniello and Rich Condit Guest: Jason McLellan Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) The New City by Dickson Despommier Prefusion-stabilized SARS-CoV-2 spikes (Science) Structure-based vaccine design (Curr Opin Immunol) Prefusion-stabilized SARS-CoV-2 S2-only antigen (Nat Comm) Stabilized coronavirus spike stem elicits broadly protective antibody (Cell Rep) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]

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