Materials scientist and physicist Guosong Hong is an expert in getting materials to do remarkable things. Recently, he and collaborators used a common food dye found in snack chips to turn living tissue transparent, allowing light to penetrate through skin and muscle. Hong is now working to realize a new age of medical imaging that lets doctors see deep into the body – without surgery. It’s a miracle of physics but it could change medicine, Hong tells host Russ Altman on this episode of Stanford Engineering’s The Future of Everything podcast.Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your quest. You can send questions to [email protected] Reference Links:Stanford Profile: ​​Guosong HongGuosong's Lab: THE HONG LABConnect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / FacebookChapters:(00:00:00) IntroductionRuss Altman introduces Guosong Hong, an expert in physics, material science, and biology from Stanford University.(00:02:52) Material Science Meets NeuroscienceHow Guosong’s research blends nanomaterials and brain science.(00:04:01) Why Tissue Isn’t TransparentThe challenge of light penetration in biological tissues.(00:05:55) A New Approach to Tissue ClearingThe physics behind tissue transparency and refractive index manipulation.(00:08:57) UV Light and TransparencyHow manipulating UV absorption can align refractive indexes.(00:11:17) First Experiments and ResultsInitial tests that demonstrate successful tissue clearing.(00:13:19) Applications in MedicineThe potential of transparent tissues in dermatology and medical imaging.(00:15:36) Testing on Live TissueThe results of testing transparency techniques on live mice.(00:19:30) Transparency in NatureHow some species have naturally transparent tissue.(00:20:52) Human Eye and Protein TransparencyThe unique proteins that keep our lenses clear using similar physics.(00:23:24) Wireless Light Inside the BodyThe development of ultrasound-activated light sources for tissue imaging.(00:26:56) Precision of Ultrasound LightHow precisely ultrasound can trigger tiny particles to emit light.(00:29:14) Conclusion
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