EPISODE SUMMARY After a short hiatus, we’re back with a straight-talk update that connects the headlines to the exam room. We unpack the CDC shakeup—what’s changing, why trust in public health wobbles, and how to separate signal from social-media noise around vaccination and guidance. Then we pivot to women’s brain health: why Alzheimer’s disproportionately affects women, what the latest midlife brain research is (and isn’t) saying, and where menopausal hormone therapy fits—timing, limits, and the right questions to bring to your own clinician. What you’ll hear: • CDC leadership changes—how they ripple into public trust and vaccine confidence • Vaccination debates: personal choice vs. population benefit, and better ways to weigh risk • Women & Alzheimer’s: the burden, the biology, and what’s new in midlife brain data • Hormone therapy in context: what timing might mean—and what guidelines actually say • Practical ways to stay evidence-anchored when health news gets loud • Our take on rebuilding trust: character, competence, and transparent communication Resources & links: • Seva Wellness: mysevawellness.com • Support the show: Thorne 15% off — thorne.com/u/thedoublescrub Education only; not medical advice. Please discuss your care with your clinician. RESEARCH DISCUSSED IN THIS EPISODE Mosconi L, Berti V, Dyke J, et al. Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-β deposition. Scientific Reports. 2021;11:10867. https://doi.org/10.1038/s41598-021-90084-y  (PubMed: https://pubmed.ncbi.nlm.nih.gov/34108509/) Mosconi L, Berti V, Guyara-Quinn C, et al. Perimenopause and emergence of an Alzheimer’s disease–like bioenergetic phenotype. PLOS ONE. 2017;12(10):e0185926. https://doi.org/10.1371/journal.pone.0185926  (PubMed: https://pubmed.ncbi.nlm.nih.gov/29016679/ ; PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC5634623/) Mosconi L, Rahman A, Diaz I, et al. Increased Alzheimer’s risk during the menopause transition: A 3-year longitudinal brain imaging study. PLOS ONE. 2018;13(12):e0207885. https://doi.org/10.1371/journal.pone.0207885  (PubMed: https://pubmed.ncbi.nlm.nih.gov/30540774/) Mosconi L, Nerattini M, Hsiao E, et al. In vivo brain estrogen receptor density by neuroendocrine aging and relationships with cognition and symptomatology. Scientific Reports. 2024;14:14154. https://doi.org/10.1038/s41598-024-62820-7  (PubMed: https://pubmed.ncbi.nlm.nih.gov/38902275/)

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