When Lung-Protective Ventilation Isn’t Brain-Protective? A Look at the PROLABI Trial

25/06/2025 6 min
When Lung-Protective Ventilation Isn’t Brain-Protective? A Look at the PROLABI Trial

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Episode Synopsis

Lung-protective ventilation (LPV), characterized by low tidal volumes and appropriate PEEP, is a cornerstone in managing patients with acute respiratory distress syndrome (ARDS). However, its application in patients with severe acute brain injury raises concerns. The potential for lung protective ventilation to increase intracranial pressure due to hypercapnia and elevated PEEP levels necessitates a closer examination of its safety and efficacy in this unique patient population.