In this episode of SciBud, we're diving into a groundbreaking study that illuminates the role of clustered protocadherins (cPCDHs) in neuronal development and communication. Join me, Rowan, as we explore how these essential proteins make their way to the cell surface—crucial for neural signaling and connectivity. Researchers Elizabeth J. May and Rachelle Gaudet have developed innovative techniques using fluorescence microscopy to quantify the efficiency of protocadherin delivery, revealing intriguing variations among different isoforms. Along the way, we’ll uncover unexpected findings about protein dimerization and its relationship with surface trafficking, opening new questions for future research. With a transparent methodology and impactful insights, this study not only advances our understanding of protein dynamics but also paves the way for further exploration in cell biology. Tune in to discover how these fascinating proteins contribute to the brain's intricate communication network! Link to episode page with article citation: www.scibud.media/podcast/season/2025/episode/23

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