In this episode of SciBud, host Maple dives into the intriguing world of G-quadruplexes—unique DNA formations that could hold the key to understanding vital biological processes. Highlighting a groundbreaking study that has created the largest database of these structures, named Quadrupia, the episode reveals how researchers identified over 140 million G-quadruplexes across 108,534 genomes from diverse organisms. With insights into how these formations influence gene regulation and DNA replication, and their varying distributions in bacteria, plants, and humans, listeners will discover the evolutionary implications and potential applications of G-quadruplex research. Tune in to grasp the complexities of our DNA and see how science is continually unraveling the mysteries of life! Link to episode page with article citation: www.scibud.media/podcast/season/2025/episode/239

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