English Podcast starts at 00:00:00Bengali Podcast starts at 00:17:11Hindi Podcast starts at 00:30:21German Podcast starts at 00:42:44ReferenceYadav, S., Lee, R. X., Kajale, S. N., Joy, B., Saha, M., Patel, P., Bull, L., Cao, S., Mitragotri, S., Bono, D., & Sarkar, D. (2025). A nonsurgical brain implant enabled through a cell–electronics hybrid for focal neuromodulation. Nature Biotechnology. https://doi.org/10.1038/s41587-025-02809-3‌Wiki page of Professor Deblina Sarkar https://en.wikipedia.org/wiki/Deblina_SarkarMIT lab page of Professor Deblina Sarkar https://web.mit.edu/deblina-sarkar/members.htmlLinkedin Post By Professor Sarkar https://www.linkedin.com/feed/update/urn:li:activity:7401077615123689472/Welcome to Revise and Resubmit 🎙️—the podcast where rejected ideas grow a spine, put on a lab coat, and walk back into the room like they own it.Today, we’re diving into a mind‑bending paper titled “A nonsurgical brain implant enabled through a cell–electronics hybrid for focal neuromodulation”, published online on 5 November 2025 in Nature Biotechnology, a prestigious journal in the Nature Portfolio. This work introduces Circulatronics 🧠⚡—tiny, wireless, photovoltaic electronic devices that hitch a ride on immune cells, travel through the bloodstream, and autonomously implant themselves into inflamed regions of the brain, enabling highly focal neuromodulation without surgery.Behind this breakthrough stands Deblina Sarkar, associate professor and AT&T Career Development Chair Professor at the MIT Media Lab, where she leads the Nano‑Cybernetic Biotrek group. Her lab fuses engineering, applied physics, and biology to bridge nanotechnology and synthetic biology, building technologies for deep life–machine symbiosis that stretch human capabilities beyond biological limits. From Kolkata and IIT (ISM) Dhanbad to UC Santa Barbara and then MIT, her path has been a continuous ascent through nanoelectronics, spintronics, and synthetic neurobiology toward exactly this kind of boundary‑breaking work.But this paper is also a story of grit: in the first two years, more than 35 grant proposals were rejected in a row because reviewers felt a surgery‑free, autonomously targeting brain implant was “impossible.” Still, Sarkar kept going—eventually demonstrating the first autonomous, nonsurgical brain implants, earning the NIH Director’s New Innovator Award with a rare, top impact score and setting off a cascade of honors. Through it all, she leaned on her father’s mantra, updated in her own voice: “Live like a Saint, Work like a Giant, and Laugh like a Child.” 💫If this blend of hardcore science and human struggle fires up your neurons, make sure you subscribe to “Revise and Resubmit” on Spotify, Amazon Prime, and Apple Podcast, and check out the YouTube channel “Weekend Researcher” for more deep‑dive stories and weekend‑friendly research breakdowns. 🎧📺Huge thanks to the authors Shubham Yadav, Ray X. Lee, Shivam N. Kajale, Baju Joy, Monochura Saha, Preet Patel, Loey Bull, Sarah Cao, Samir Mitragotri, David Bono, and Deblina Sarkar, and to Nature Biotechnology and Nature for publishing this remarkable work. 🙏 So as electronics ride inside immune cells and quietly reimagine what a brain implant can be, here’s the question to start today’s episode: if we can send tiny machines through our veins to heal the brain, what other “impossible” frontiers are we about to cross next? 🤯✨

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