Rethinking healthy ageing in dogs with Dr Matthew Muir

05/08/2025 54 min Episodio 73
Rethinking healthy ageing in dogs with Dr Matthew Muir

Listen "Rethinking healthy ageing in dogs with Dr Matthew Muir"

Episode Synopsis

In this episode Dr Sarah Howard discusses healthy ageing in dogs with Dr Matthew Muir. Topics discussed include: The reason ageing is currently a hot topic. What leads to an increased lifespan and better quality of life? Diet changes that can impact ageing in dogs. Dr Muir discusses what we should avoid in order to increase lifespan. Matthew goes into details of what dogs' diets should look like to prevent disease. How often should we be feeding our pets? What happens to the gut microbiome as dogs get older?  Dr Muir delves into supplements that can be beneficial for ageing and emerging tools that are becoming available. The importance of preventative medicine - proactive vs reactive care. Accelerators of biological ageing. Additional resources: https://pubmed.ncbi.nlm.nih.gov/11991408/ https://pmc.ncbi.nlm.nih.gov/articles/PMC11675035/https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2024.1355560/full https://pmc.ncbi.nlm.nih.gov/articles/PMC11505706/ https://www.mdpi.com/1660-3397/18/11/564https://pmc.ncbi.nlm.nih.gov/articles/PMC4936929/ https://pubmed.ncbi.nlm.nih.gov/22216092/    Adams VJ, Watson P, Carmichael S, Gerry S, Penell J, Morgan DM. Exceptional longevity and potential determinants of successful ageing in a cohort of 39 Labrador retrievers: results of a prospective longitudinal study. Acta Vet Scand. 2016;58:29. doi:10.1186/s13028-016-0204-8 Cupp CJ, Jean-Philippe C, Kerr WW, Patil AR. Effect of nutritional interventions on longevity of senior cats. Int J Appl Res Vet Med. 2007;5(3):133–149 Bermingham EN, Patterson KA, Shoveller AK, Fraser K, Butowski CF, Thomas DG. Nutritional needs and health outcomes of ageing cats and dogs: is it time for updated nutrient guidelines? Anim Front. 2024;14(3):5–16. doi:10.1093/af/vfae008 Jackson J, Radford AD, Belshaw Z, Wallis LJ, Kubinyi E, German AJ, Westgarth C. Using veterinary health records at scale to investigate ageing dogs and their common issues in primary care. J Small Anim Pract. 2025;66(2):81–91. doi:10.1111/jsap.13809 Creevy KE, O'Neill DG, Promislow DEL. Morbidity and mortality in elderly dogs – a model for human aging. BMC Vet Res. 2022;18(1):456. doi:10.1186/s12917-022-03518-8 Lewis TW, Wiles BM, Llewellyn-Zaidi AM, Evans KM, O’Neill DG. Longevity and mortality in Kennel Club registered dog breeds in the UK in 2014. Canine Genet Epidemiol. 2018;5:10. doi:10.1186/s40575-018-0066-8 Kealy RD, Lawler DF, Ballam JM, Mantz SL, Biery DN, Greeley EH, Lust G, Segre M, Smith GK, Stowe HD. Effects of diet restriction on life span and age-related changes in dogs. J Am Vet Med Assoc. 2002;220(9):1315–1320. doi:10.2460/javma.2002.220.1315 Guelfi G, Capaccia C, Tedeschi M, Bufalari A, Leonardi L, Cenci-Goga B, Maranesi M. Dog aging: a comprehensive review of molecular, cellular, and physiological processes. Cells. 2024;13(24):2101. doi:10.3390/cells13242101 Laflamme DP. Nutritional care for aging cats and dogs. Vet Clin North Am Small Anim Pract. 2012;42(4):769–791. doi:10.1016/j.cvsm.2012.04.002 Hall JA, Jewell DE. Feeding healthy beagles medium-chain triglycerides, fish oil, and L-carnitine offsets age-related changes in serum fatty acids and carnitine metabolites. PLoS One. 2012;7(11):e49510. doi:10.1371/journal.pone.0049510 Bermingham EN, Patterson KA, Shoveller AK, Fraser K, Butowski CF, Thomas DG. Nutritional needs and health outcomes of ageing cats and dogs: is it time for updated nutrient guidelines? Anim Front. 2024;14(3):5–16. doi:10.1093/af/vfae008 Bray EE, Zheng Z, Tolbert MK, McCoy BM, Kaeberlein M, Kerr KF; Dog Aging Project Consortium. Once-daily feeding is associated with better health in companion dogs: results from the Dog Aging Project. GeroScience. 2022;44(3):1779–1790. doi:10.1007/s11357-022-00575-7 Palaseweenun P, Hagen‐Plantinga EA, Schonewille JT, Koop G, Butre C, Jonathan M, Wierenga PA, Hendriks WH. Urinary excretion of advanced glycation end products in dogs and cats. J Anim Physiol Anim Nutr (Berl). 2021;105(1):149–156. doi:10.1111/jpn.13347 Yang L, Yang L, Cai Y, Luo Y, Wang H, Wang L, Chen J, Liu X, Wu Y, Qin Y, Wu Z, Liu N. Natural mycotoxin contamination in dog food: a review on toxicity and detoxification methods. Ecotoxicol Environ Saf. 2023;257:114948. doi:10.1016/j.ecoenv.2023.114948 Bridglalsingh S, Archer-Hartmann S, Azadi P, Barbier de La Serre C, Remillard RL, Sunvold GD, Bartges JW. Association of four differently processed diets with plasma and urine advanced glycation end products and serum soluble receptor for advanced glycation end products concentration in healthy dogs. J Anim Physiol Anim Nutr (Berl). 2024;108(3):735–751. doi:10.1111/jpn.13927 Marchi PH, Vendramini THA, Perini MP, Zafalon RVA, Amaral AR, Ochamotto VA, Da Silveira JC, Dagli MLZ, Brunetto MA. Obesity, inflammation, and cancer in dogs: review and perspectives. Front Vet Sci. 2022;9:1004122. doi:10.3389/fvets.2022.1004122 Schmid SM, Hoffman JM, Prescott J, Ernst H, Promislow DEL, Creevy KE; Dog Aging Project Consortium. The companion dog as a model for inflammaging: a cross-sectional pilot study. GeroScience. 2024;46(6):5395–5407. doi:10.1007/s11357-024-01217-w Ren J, Li H, Zeng G, Pang B, Wang Q, Wei J. Gut microbiome-mediated mechanisms in aging-related diseases: are probiotics ready for prime time? Front Pharmacol. 2023;14:1178596. doi:10.3389/fphar.2023.1178596 Parker A, Romano S, Ansorge R, Aboelnour A, Le Gall G, Savva GM, Pontifex MG, Telatin A, Baker D, Jones E, Vauzour D, Rudder S, Blackshaw LA, Jeffery G, Carding SR. Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain. Microbiome. 2022;10:68. doi:10.1186/s40168-022-01262-3 Ulluwishewa D, Anderson RC, McNabb WC, et al. Regulation of tight junction permeability by intestinal bacteria and dietary components. J Nutr. 2011;141(5):769–76. doi:10.3945/jn.110.135657 Cao L, Lee SG, Lim KT, Kim HR. Potential anti-aging substances derived from seaweeds. Mar Drugs. 2020;18(11):564. doi:10.3390/md18110564 Grzeczka A, Graczyk S, Kordowitzki P. Pleiotropic effects of resveratrol on aging-related cardiovascular diseases—what can we learn from research in dogs? Cells. 2024;13(20):1732. doi:10.3390/cells13201732 Kusaba A, Arai T. Shiitake mushroom powder supplementation increases antioxidative activity in dogs. Front Vet Sci. 2024;11:1355560. doi:10.3389/fvets.2024.1355560 Cho HW, Choi S, Seo K, Kim KH, Jeon JH, Kim CH, Lim S, Jeong S, Chun JL. Gut microbiota profiling in aged dogs after feeding pet food contained Hericium erinaceus. J Anim Sci Technol. 2022 Sep;64(5):937-949. Kaur J, Seshadri S, Golla KH, Sampara P. Efficacy and safety of standardized ashwagandha (Withania somnifera) root extract on reducing stress and anxiety in domestic dogs: A randomized controlled trial. J Vet Behav. 2022;51:8–15. Bharani KK, Devarasetti AK, Carey L, Khurana A, Kollipaka R, Hanuman DDV, Chetla VS, Banothu AK. Effects of ashwagandha (Withania somnifera) root extract on aging-related changes in healthy geriatric dogs: A randomized, double-blinded placebo-controlled study. Vet Med Sci. 2024 Sep;10(5):e1556 Sacoor C, Marugg JD, Lima NR, Empadinhas N, Montezinho L. Gut-brain axis impact on canine anxiety disorders: new challenges for behavioral veterinary medicine. Vet Med Int. 2024;2024:2856759. doi:10.1155/2024/2856759 Lee E, Carreras-Gallo N, Lopez L, Turner L, Lin A, Mendez TL, Went H, Tomusiak A, Verdin E, Corley M, Ndhlovu L, Smith R, Dwaraka VB. Exploring the effects of Dasatinib, Quercetin, and Fisetin on DNA methylation clocks: a longitudinal study on senolytic interventions. Aging (Albany NY). 2024;16(4):3088–3106. doi:10.18632/aging.205581 Bitto A, Ito TK, Pineda VV, LeTexier NJ, Huang HZ, Sutlief E, Tung H, Vizzini N, Chen B, Smith K, Meza D, Yajima M, Beyer RP, Kerr KF, Davis DJ, Gillespie CH, Snyder JM, Treuting PM, Kaeberlein M. Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice. eLife. 2016;5:e16351. doi:10.7554/eLife.16351 Urfer SR, Kaeberlein TL, Mailheau S, Bergman PJ, Creevy KE, Promislow DEL, Kaeberlein M. A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs. GeroScience. 2017;39(2):117–127. doi:10.1007/s11357-017-9972-z Kaeberlein M, Creevy KE, Promislow DEL. The Dog Aging Project: translational geroscience in companion animals. Mamm Genome. 2016;27(7–8):279–288. doi:10.1007/s00335-016-9638- Mulder IE, Schmidt B, Lewis M, Delday M, Stokes CR, Bailey M, Aminov RI, Gill BP, Pluske JR, Mayer CD, Kelly D. Restricting microbial exposure in early life negates the immune benefits associated with gut colonization in environments of high microbial diversity. PLoS One. 2011;6(12):e28279. doi:10.1371/journal.pone.0028279 Hemida M, Vuori KA, Moore R, Anturaniemi J, Hielm-Björkman A. Early life modifiable exposures and their association with owner-reported inflammatory bowel disease symptoms in adult dogs. Front Vet Sci. 2021;8:552350. doi:10.3389/fvets.2021.552350 McMahon JE, Graves JL, Tovar AP, Peloquin M, Greenwood K, Chen FL, Nelson M, McCandless EE, Halioua-Haubold CL, Juarez-Salinas D. Translational immune and metabolic markers of aging in dogs. Sci Rep. 2025;15:14460. doi:10.1038/s41598-025-51976-3 Urfer SR, Kaeberlein M. Desexing dogs: a review of the current literature. Animals (Basel). 2019;9(12):1086. doi:10.3390/ani9121086 Santos JDP, Cunha E, Nunes T, Tavares L, Oliveira M. Relation between periodontal disease and systemic diseases in dogs. Res Vet Sci. 2019;125:136–140. doi:10.1016/j.rvsc.2019.05.011 Selting KA, Ringold R, Husbands B, Pithua PO. Thymidine kinase type 1 and C-reactive protein concentrations in dogs with spontaneously occurring cancer. J Vet Intern Med. 2016;30(4):1159–1166. doi:10.1111/jvim.13954 Urfer SR, Kaeberlein M. Desexing dogs: a review of the current literature. Animals (Basel). 2019;9(12):1086. doi:10.3390/ani9121086 Clark JD, Rager DR, Crowell-Davis S, Evans DL. Housing and exercise of dogs: effects on behaviour, immune function and cortisol concentration. Lab Anim Sci. 1997;47(5):500–510 See omnystudio.com/listener for privacy information.

More episodes of the podcast pureANIMAL Collective