What if biotech’s biggest scaling challenge isn’t technical—but philosophical? In this episode, Massimo Portincaso, founder and CEO of Arsenale Bioyards, explains why industrial biotech must be reimagined from the ground up. He challenges legacy “scale-up” thinking, highlighting biology’s context dependency and the economic dead ends of retrofitted pharma models. From modular, AI-informed bioreactors to a scale-out strategy and data-first infrastructure, Massimo shares how his team is rewriting the rules of economic viability, manufacturing innovation, and organizational design. Discover why scaling out — not up — is the future of biomanufacturing.--- Hey Climate Tech enthusiasts! Searching for new podcasts on sustainability? Check out the Leaders on a Mission podcast, where I interview climate tech leaders who are shaking up the industry and bringing us the next big thing in sustainable solutions. Join me for a deep dive into the future of green innovation exploring the highs, lows, and everything in between of pioneering new technologies.Get an exclusive insight into how these leaders started up their journey, and how their cutting edge products will make a real impact. Tune in on…YouTube: https://www.youtube.com/@leadersonamissionNet0Spotify: https://open.spotify.com/show/7o41ubdkzChAzD9C53xH82Apple Podcasts: https://podcasts.apple.com/us/podcast/leaders-on-a-mission/id1532211726…to listen to the latest episodes!Timestamps:00:46 - Biology resists code scaling03:18 -  From BCG to biotech founder07:33 -  Why biotech remains niche10:24  - Redesigning from first principles13:40 -  Biology's context dependency16:55  - Intelligent design via Bayesian models18:46 -  Building the bioproduction stack21:00 -  Scale-out vs scale-up25:56 -  Rethinking the CDMO model29:20 -  Reinventing the capital stack33:30 -  Future sectors & applications37:10 -   Killing the org chart40:12 -  Complexity as a strategic assetUseful links: Arsenale Bioyards website: https://arsenale.bio/Arsenale Bioywards LinkedIn: https://www.linkedin.com/company/arsenale-bioyards/Massimo Portincaso LinkedIn: https://www.linkedin.com/in/massimo-portincaso-36a8795/Leaders on a Mission website: https://cs-partners.net/podcasts/Simon Leich’s LinkedIn: https://www.linkedin.com/in/executive-talent-headhunter-agtech-foodtech-agrifoodtech-agritech/

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