In this episode of Hypertrophy: Past and Present, Jake and Chris explore Sig Klein’s early A/B full body routine from the pre-steroid bodybuilding era before examining the claim that elevated myofibrillar protein synthesis blunts the effectiveness of subsequent workouts.Key topics include:Sig Klein’s beginner routine The difference between myofibrillar protein synthesis and hypertrophy stimulusWhat comparing one vs three set studies shows us about elevated synthesis timelinesWhy any overlap effect is small (and irrelevant for single-set workouts)Why the weekly net stimulus still favours three times per week over two times per week training

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