Whether you sip it with friends, chug it before hitting the dance floor, or take it as a post-work pick-me-up, there’s clearly nothing like a cocktail for bracing the spirit. In addition to its peculiar history as a medicinal tonic, plenty of hard science lies behind the perfect cocktail, from the relationship between taste perception and temperature to the all-important decision of whether to shake or stir.

What’s more, according to historian David Wondrich, mixology is “the first legitimate American culinary art”—and one that has since caught on around the world. Raise a glass, and listen in as we discover the cocktail’s historical origins, its etymological connection to a horse’s butt, and its rocky history, post-Prohibition. We also check out an original copy of the world’s first cocktail recipe book at New York City’s bartending mecca, Cocktail Kingdom; take a private cocktail science class with Jared Sadoian of The Hawthorne in Boston; and talk red-hot pokers with culinary scientist Dave Arnold. Cheers!
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