🧬 Can we rejuvenate the aging immune system? A new Nature Aging trial suggests we might be closer than we thought.   In 50 healthy adults aged 45–70, urolithin A—a mitophagy activator—improved immune fitness over just 28 days: ✅ ↑ naïve CD8⁺ T cells ✅ ↓ exhaustion markers (TOX) ✅ ↑ mitochondrial biogenesis (PGC-1α) ✅ ↑ fatty-acid oxidation capacity ✅ ↑ NK cell and monocyte function ✅ ↑ bacterial phagocytosis 💊 Well-tolerated with minimal adverse events   🔬 This builds on compelling translational work linking mitochondrial quality control to immunosenescence and "inflammaging."   A reminder that metabolism and immunity are deeply intertwined—and that targeted interventions may help preserve immune resilience across the lifespan.   🧠 Aging isn't just years lived. It's biology modulated.   #LongevityScience #Immunology #HealthyAging #Mitochondria #ClinicalResearch #TranslationalScience #Geroscience #ImmuneHealth #NatureAging

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