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Listen "AI Echo Predicts Transthyretin Amyloid Outcomes 10/17/25"
Episode Synopsis
Welcome to Cardiology Today – Recorded October 17, 2025. This episode summarizes 5 key cardiology studies on topics like transthyretin cardiac amyloidosis and Neutrophil-to-lymphocyte ratio. Key takeaway: AI Echo Predicts Transthyretin Amyloid Outcomes.
Article Links:
Article 1: Prevalence and Associations of Systemic Inflammation in Heart Failure Across the Spectrum of Ejection Fraction. (JACC. Heart failure)
Article 2: Prognostic Value of Papillary Muscle Scarring in Patients With Dilated Cardiomyopathy. (JAMA cardiology)
Article 3: Neutrophil-to-lymphocyte ratio for risk stratification in acute myocarditis across the left ventricular ejection fraction spectrum. (European journal of heart failure)
Article 4: Artificial intelligence-based echocardiographic assessment for monitoring disease progression in transthyretin cardiac amyloidosis. (European journal of heart failure)
Article 5: Expression of Concern: Netrin-1 Preserves Blood-Brain Barrier Integrity Through Deleted in Colorectal Cancer/Focal Adhesion Kinase/RhoA Signaling Pathway Following Subarachnoid Hemorrhage in Rats. (Journal of the American Heart Association)
Full episode page: https://podcast.explainheart.com/podcast/ai-echo-predicts-transthyretin-amyloid-outcomes-10-17-25/
Featured Articles
Article 1: Prevalence and Associations of Systemic Inflammation in Heart Failure Across the Spectrum of Ejection Fraction.
Journal: JACC. Heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41099689
Summary: This study characterized the prevalence and correlates of systemic inflammation across the spectrum of heart failure, including heart failure with reduced ejection fraction, heart failure with mildly reduced ejection fraction, and heart failure with preserved ejection fraction. It aimed to differentiate inflammatory mechanisms, where inflammation in heart failure with mildly reduced ejection fraction and heart failure with preserved ejection fraction is linked to cardiovascular-kidney-metabolic conditions. In contrast, inflammation in heart failure with reduced ejection fraction is thought to develop secondary to cardiac stress and circulatory derangements. This research establishes a crucial foundation for understanding distinct inflammatory profiles in varying heart failure phenotypes, which is vital for developing targeted therapeutic strategies.
Article 2: Prognostic Value of Papillary Muscle Scarring in Patients With Dilated Cardiomyopathy.
Journal: JAMA cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41091460
Summary: This cohort study was designed to investigate the prevalence and prognostic significance of papillary muscle scarring in patients with dilated cardiomyopathy. Recognizing that papillary muscle scarring can arise from microvascular dysfunction, even without epicardial coronary artery disease, the study aimed to establish whether this scarring is associated with adverse outcomes in this patient population. By clarifying the presence and impact of papillary muscle scarring in dilated cardiomyopathy, this research sought to provide crucial insights for enhanced risk stratification and personalized management strategies. The study thereby establishes a framework for future prognostic assessment in patients with dilated cardiomyopathy.
Article 3: Neutrophil-to-lymphocyte ratio for risk stratification in acute myocarditis across the left ventricular ejection fraction spectrum.
Journal: European journal of heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41098018
Summary: This study aimed to compare the predictive accuracy of various risk stratification models for acute myocarditis, with a specific focus on the utility of the neutrophil-to-lymphocyte ratio. The research recognized that the neutrophil-to-lymphocyte ratio (N.L.R.) is a valuable tool for risk stratification in patients with acute myocarditis, particularly addressing challenges in those presenting with preserved left ventricular ejection fraction (L.V.E.F.). By evaluating existing models and emphasizing the predictive power of N.L.R., this study significantly advances the ability to identify high-risk patients. These findings offer a more robust method for risk stratification in acute myocarditis across the left ventricular ejection fraction spectrum, enabling more precise clinical management and potentially improving patient outcomes.
Article 4: Artificial intelligence-based echocardiographic assessment for monitoring disease progression in transthyretin cardiac amyloidosis.
Journal: European journal of heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41098006
Summary: This study investigated artificial intelligence-based echocardiographic assessment for monitoring disease progression in transthyretin cardiac amyloidosis. Researchers conducted longitudinal transthoracic echocardiography on consecutive patients with transthyretin cardiac amyloidosis at baseline and 12-month follow-up, utilizing artificial intelligence for rapid and standardized assessment of left ventricular outflow tract velocity-time integral (L.V.O.T.-V.T.I.). This work successfully established an artificial intelligence-driven approach for objectively quantifying changes in L.V.O.T.-V.T.I., a reliable surrogate for stroke volume, which is known to portend a poor prognosis when reduced. This innovative methodology provides a standardized and efficient tool to predict outcomes and guide therapeutic management in patients with transthyretin cardiac amyloidosis.
Article 5: Expression of Concern: Netrin-1 Preserves Blood-Brain Barrier Integrity Through Deleted in Colorectal Cancer/Focal Adhesion Kinase/RhoA Signaling Pathway Following Subarachnoid Hemorrhage in Rats.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41085211
Summary: The Journal of the American Heart Association is issuing an Expression of Concern regarding a previously published article titled “Netrin-1 Preserves Blood-Brain Barrier Integrity Through Deleted in Colorectal Cancer/Focal Adhesion Kinase/RhoA Signaling Pathway Following Subarachnoid Hemorrhage in Rats.” This notice addresses significant concerns that were raised regarding the quality of the data and images presented within the article. The Expression of Concern underscores the journal’s commitment to maintaining rigorous scientific standards and integrity in published research. It highlights the critical importance of data accuracy and transparency in the scientific literature.
Transcript
Today’s date is October 17, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Prevalence and Associations of Systemic Inflammation in Heart Failure Across the Spectrum of Ejection Fraction. This study characterized the prevalence and correlates of systemic inflammation across the spectrum of heart failure, including heart failure with reduced ejection fraction, heart failure with mildly reduced ejection fraction, and heart failure with preserved ejection fraction. It aimed to differentiate inflammatory mechanisms, where inflammation in heart failure with mildly reduced ejection fraction and heart failure with preserved ejection fraction is linked to cardiovascular-kidney-metabolic conditions. In contrast, inflammation in heart failure with reduced ejection fraction is thought to develop secondary to cardiac stress and circulatory derangements. This research establishes a crucial foundation for understanding distinct inflammatory profiles in varying heart failure phenotypes, which is vital for developing targeted therapeutic strategies.
Article number two. Prognostic Value of Papillary Muscle Scarring in Patients With Dilated Cardiomyopathy. This cohort study was designed to investigate the prevalence and prognostic significance of papillary muscle scarring in patients with dilated cardiomyopathy. Recognizing that papillary muscle scarring can arise from microvascular dysfunction, even without epicardial coronary artery disease, the study aimed to establish whether this scarring is associated with adverse outcomes in this patient population. By clarifying the presence and impact of papillary muscle scarring in dilated cardiomyopathy, this research sought to provide crucial insights for enhanced risk stratification and personalized management strategies. The study thereby establishes a framework for future prognostic assessment in patients with dilated cardiomyopathy.
Article number three. Neutrophil-to-lymphocyte ratio for risk stratification in acute myocarditis across the left ventricular ejection fraction spectrum. This study aimed to compare the predictive accuracy of various risk stratification models for acute myocarditis, with a specific focus on the utility of the neutrophil-to-lymphocyte ratio. The research recognized that the neutrophil-to-lymphocyte ratio (N.L.R.) is a valuable tool for risk stratification in patients with acute myocarditis, particularly addressing challenges in those presenting with preserved left ventricular ejection fraction (L.V.E.F.). By evaluating existing models and emphasizing the predictive power of N.L.R., this study significantly advances the ability to identify high-risk patients. These findings offer a more robust method for risk stratification in acute myocarditis across the left ventricular ejection fraction spectrum, enabling more precise clinical management and potentially improving patient outcomes.
Article number four. Artificial intelligence-based echocardiographic assessment for monitoring disease progression in transthyretin cardiac amyloidosis. This study investigated artificial intelligence-based echocardiographic assessment for monitoring disease progression in transthyretin cardiac amyloidosis. Researchers conducted longitudinal transthoracic echocardiography on consecutive patients with transthyretin cardiac amyloidosis at baseline and 12-month follow-up, utilizing artificial intelligence for rapid and standardized assessment of left ventricular outflow tract velocity-time integral (L.V.O.T.-V.T.I.). This work successfully established an artificial intelligence-driven approach for objectively quantifying changes in L.V.O.T.-V.T.I., a reliable surrogate for stroke volume, which is known to portend a poor prognosis when reduced. This innovative methodology provides a standardized and efficient tool to predict outcomes and guide therapeutic management in patients with transthyretin cardiac amyloidosis.
Article number five. Expression of Concern: Netrin-1 Preserves Blood-Brain Barrier Integrity Through Deleted in Colorectal Cancer/Focal Adhesion Kinase/RhoA Signaling Pathway Following Subarachnoid Hemorrhage in Rats. The Journal of the American Heart Association is issuing an Expression of Concern regarding a previously published article titled “Netrin-1 Preserves Blood-Brain Barrier Integrity Through Deleted in Colorectal Cancer/Focal Adhesion Kinase/RhoA Signaling Pathway Following Subarachnoid Hemorrhage in Rats.” This notice addresses significant concerns that were raised regarding the quality of the data and images presented within the article. The Expression of Concern underscores the journal’s commitment to maintaining rigorous scientific standards and integrity in published research. It highlights the critical importance of data accuracy and transparency in the scientific literature.
Thank you for listening. Don’t forget to subscribe.
Keywords
transthyretin cardiac amyloidosis, Neutrophil-to-lymphocyte ratio, adverse outcomes, echocardiography, left ventricular outflow tract velocity-time integral, left ventricular ejection fraction, prognostic value, heart failure with reduced ejection fraction, data quality, dilated cardiomyopathy, Artificial intelligence, acute myocarditis, blood-brain barrier, microvascular dysfunction, systemic inflammation, scientific integrity, Expression of Concern, Heart failure with preserved ejection fraction, Papillary muscle scarring, heart failure with mildly reduced ejection fraction, subarachnoid hemorrhage, cardiovascular-kidney-metabolic conditions, disease progression monitoring, risk stratification, preserved ejection fraction.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post AI Echo Predicts Transthyretin Amyloid Outcomes 10/17/25 first appeared on Cardiology Today.
Article Links:
Article 1: Prevalence and Associations of Systemic Inflammation in Heart Failure Across the Spectrum of Ejection Fraction. (JACC. Heart failure)
Article 2: Prognostic Value of Papillary Muscle Scarring in Patients With Dilated Cardiomyopathy. (JAMA cardiology)
Article 3: Neutrophil-to-lymphocyte ratio for risk stratification in acute myocarditis across the left ventricular ejection fraction spectrum. (European journal of heart failure)
Article 4: Artificial intelligence-based echocardiographic assessment for monitoring disease progression in transthyretin cardiac amyloidosis. (European journal of heart failure)
Article 5: Expression of Concern: Netrin-1 Preserves Blood-Brain Barrier Integrity Through Deleted in Colorectal Cancer/Focal Adhesion Kinase/RhoA Signaling Pathway Following Subarachnoid Hemorrhage in Rats. (Journal of the American Heart Association)
Full episode page: https://podcast.explainheart.com/podcast/ai-echo-predicts-transthyretin-amyloid-outcomes-10-17-25/
Featured Articles
Article 1: Prevalence and Associations of Systemic Inflammation in Heart Failure Across the Spectrum of Ejection Fraction.
Journal: JACC. Heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41099689
Summary: This study characterized the prevalence and correlates of systemic inflammation across the spectrum of heart failure, including heart failure with reduced ejection fraction, heart failure with mildly reduced ejection fraction, and heart failure with preserved ejection fraction. It aimed to differentiate inflammatory mechanisms, where inflammation in heart failure with mildly reduced ejection fraction and heart failure with preserved ejection fraction is linked to cardiovascular-kidney-metabolic conditions. In contrast, inflammation in heart failure with reduced ejection fraction is thought to develop secondary to cardiac stress and circulatory derangements. This research establishes a crucial foundation for understanding distinct inflammatory profiles in varying heart failure phenotypes, which is vital for developing targeted therapeutic strategies.
Article 2: Prognostic Value of Papillary Muscle Scarring in Patients With Dilated Cardiomyopathy.
Journal: JAMA cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41091460
Summary: This cohort study was designed to investigate the prevalence and prognostic significance of papillary muscle scarring in patients with dilated cardiomyopathy. Recognizing that papillary muscle scarring can arise from microvascular dysfunction, even without epicardial coronary artery disease, the study aimed to establish whether this scarring is associated with adverse outcomes in this patient population. By clarifying the presence and impact of papillary muscle scarring in dilated cardiomyopathy, this research sought to provide crucial insights for enhanced risk stratification and personalized management strategies. The study thereby establishes a framework for future prognostic assessment in patients with dilated cardiomyopathy.
Article 3: Neutrophil-to-lymphocyte ratio for risk stratification in acute myocarditis across the left ventricular ejection fraction spectrum.
Journal: European journal of heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41098018
Summary: This study aimed to compare the predictive accuracy of various risk stratification models for acute myocarditis, with a specific focus on the utility of the neutrophil-to-lymphocyte ratio. The research recognized that the neutrophil-to-lymphocyte ratio (N.L.R.) is a valuable tool for risk stratification in patients with acute myocarditis, particularly addressing challenges in those presenting with preserved left ventricular ejection fraction (L.V.E.F.). By evaluating existing models and emphasizing the predictive power of N.L.R., this study significantly advances the ability to identify high-risk patients. These findings offer a more robust method for risk stratification in acute myocarditis across the left ventricular ejection fraction spectrum, enabling more precise clinical management and potentially improving patient outcomes.
Article 4: Artificial intelligence-based echocardiographic assessment for monitoring disease progression in transthyretin cardiac amyloidosis.
Journal: European journal of heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41098006
Summary: This study investigated artificial intelligence-based echocardiographic assessment for monitoring disease progression in transthyretin cardiac amyloidosis. Researchers conducted longitudinal transthoracic echocardiography on consecutive patients with transthyretin cardiac amyloidosis at baseline and 12-month follow-up, utilizing artificial intelligence for rapid and standardized assessment of left ventricular outflow tract velocity-time integral (L.V.O.T.-V.T.I.). This work successfully established an artificial intelligence-driven approach for objectively quantifying changes in L.V.O.T.-V.T.I., a reliable surrogate for stroke volume, which is known to portend a poor prognosis when reduced. This innovative methodology provides a standardized and efficient tool to predict outcomes and guide therapeutic management in patients with transthyretin cardiac amyloidosis.
Article 5: Expression of Concern: Netrin-1 Preserves Blood-Brain Barrier Integrity Through Deleted in Colorectal Cancer/Focal Adhesion Kinase/RhoA Signaling Pathway Following Subarachnoid Hemorrhage in Rats.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41085211
Summary: The Journal of the American Heart Association is issuing an Expression of Concern regarding a previously published article titled “Netrin-1 Preserves Blood-Brain Barrier Integrity Through Deleted in Colorectal Cancer/Focal Adhesion Kinase/RhoA Signaling Pathway Following Subarachnoid Hemorrhage in Rats.” This notice addresses significant concerns that were raised regarding the quality of the data and images presented within the article. The Expression of Concern underscores the journal’s commitment to maintaining rigorous scientific standards and integrity in published research. It highlights the critical importance of data accuracy and transparency in the scientific literature.
Transcript
Today’s date is October 17, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Prevalence and Associations of Systemic Inflammation in Heart Failure Across the Spectrum of Ejection Fraction. This study characterized the prevalence and correlates of systemic inflammation across the spectrum of heart failure, including heart failure with reduced ejection fraction, heart failure with mildly reduced ejection fraction, and heart failure with preserved ejection fraction. It aimed to differentiate inflammatory mechanisms, where inflammation in heart failure with mildly reduced ejection fraction and heart failure with preserved ejection fraction is linked to cardiovascular-kidney-metabolic conditions. In contrast, inflammation in heart failure with reduced ejection fraction is thought to develop secondary to cardiac stress and circulatory derangements. This research establishes a crucial foundation for understanding distinct inflammatory profiles in varying heart failure phenotypes, which is vital for developing targeted therapeutic strategies.
Article number two. Prognostic Value of Papillary Muscle Scarring in Patients With Dilated Cardiomyopathy. This cohort study was designed to investigate the prevalence and prognostic significance of papillary muscle scarring in patients with dilated cardiomyopathy. Recognizing that papillary muscle scarring can arise from microvascular dysfunction, even without epicardial coronary artery disease, the study aimed to establish whether this scarring is associated with adverse outcomes in this patient population. By clarifying the presence and impact of papillary muscle scarring in dilated cardiomyopathy, this research sought to provide crucial insights for enhanced risk stratification and personalized management strategies. The study thereby establishes a framework for future prognostic assessment in patients with dilated cardiomyopathy.
Article number three. Neutrophil-to-lymphocyte ratio for risk stratification in acute myocarditis across the left ventricular ejection fraction spectrum. This study aimed to compare the predictive accuracy of various risk stratification models for acute myocarditis, with a specific focus on the utility of the neutrophil-to-lymphocyte ratio. The research recognized that the neutrophil-to-lymphocyte ratio (N.L.R.) is a valuable tool for risk stratification in patients with acute myocarditis, particularly addressing challenges in those presenting with preserved left ventricular ejection fraction (L.V.E.F.). By evaluating existing models and emphasizing the predictive power of N.L.R., this study significantly advances the ability to identify high-risk patients. These findings offer a more robust method for risk stratification in acute myocarditis across the left ventricular ejection fraction spectrum, enabling more precise clinical management and potentially improving patient outcomes.
Article number four. Artificial intelligence-based echocardiographic assessment for monitoring disease progression in transthyretin cardiac amyloidosis. This study investigated artificial intelligence-based echocardiographic assessment for monitoring disease progression in transthyretin cardiac amyloidosis. Researchers conducted longitudinal transthoracic echocardiography on consecutive patients with transthyretin cardiac amyloidosis at baseline and 12-month follow-up, utilizing artificial intelligence for rapid and standardized assessment of left ventricular outflow tract velocity-time integral (L.V.O.T.-V.T.I.). This work successfully established an artificial intelligence-driven approach for objectively quantifying changes in L.V.O.T.-V.T.I., a reliable surrogate for stroke volume, which is known to portend a poor prognosis when reduced. This innovative methodology provides a standardized and efficient tool to predict outcomes and guide therapeutic management in patients with transthyretin cardiac amyloidosis.
Article number five. Expression of Concern: Netrin-1 Preserves Blood-Brain Barrier Integrity Through Deleted in Colorectal Cancer/Focal Adhesion Kinase/RhoA Signaling Pathway Following Subarachnoid Hemorrhage in Rats. The Journal of the American Heart Association is issuing an Expression of Concern regarding a previously published article titled “Netrin-1 Preserves Blood-Brain Barrier Integrity Through Deleted in Colorectal Cancer/Focal Adhesion Kinase/RhoA Signaling Pathway Following Subarachnoid Hemorrhage in Rats.” This notice addresses significant concerns that were raised regarding the quality of the data and images presented within the article. The Expression of Concern underscores the journal’s commitment to maintaining rigorous scientific standards and integrity in published research. It highlights the critical importance of data accuracy and transparency in the scientific literature.
Thank you for listening. Don’t forget to subscribe.
Keywords
transthyretin cardiac amyloidosis, Neutrophil-to-lymphocyte ratio, adverse outcomes, echocardiography, left ventricular outflow tract velocity-time integral, left ventricular ejection fraction, prognostic value, heart failure with reduced ejection fraction, data quality, dilated cardiomyopathy, Artificial intelligence, acute myocarditis, blood-brain barrier, microvascular dysfunction, systemic inflammation, scientific integrity, Expression of Concern, Heart failure with preserved ejection fraction, Papillary muscle scarring, heart failure with mildly reduced ejection fraction, subarachnoid hemorrhage, cardiovascular-kidney-metabolic conditions, disease progression monitoring, risk stratification, preserved ejection fraction.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post AI Echo Predicts Transthyretin Amyloid Outcomes 10/17/25 first appeared on Cardiology Today.
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