Listen "๐๏ธ Episode 15: Fine-tuning HFpEF: Finerenone Finds Its Footing"
Episode Synopsis
Send us a text๐ง Clinical Problem:HFpEF (Heart Failure with Preserved EF) has lacked effective, proven therapies.Finerenone (non-steroidal MRA) offers new hope.๐งช FINEARTS-HF Trial:6,000+ patients with EF โฅ40%, followed for ~32 months.Compared Finerenone vs placebo.๐ Results:โ Heart failure hospitalization significantly.No significant reduction in CV mortality.Hyperkalemia: 9.7% (Finerenone) vs 4.2% (Placebo).๐งฉ Clinical Takeaway:May offer benefit for HFpEF โ especially if SGLT2i also used.Expensive; Spironolactone may be a lower-cost alternative with similar benefit.Important addition to the limited HFpEF toolbox.
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