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Listen "S01E01 - Prof. Colin Masters on the amyloid hypothesis of Alzheimer's disease."
Episode Synopsis
Professor Colin Masters is a professor at the Florey Institute of the Neuroscience and Mental Health and the University of Melbourne. In this episode, he recounts his pivotal role in the establishment of the amyloid hypothesis of Alzheimer's disease and the stages of research that led to his current work on treatments and biomarkers. Here is an excerpt from his bio on the Florey page:
"Over the last 40 years, his work is widely acknowledged as having had a major influence on Alzheimer’s disease research worldwide, particularly the collaborative studies conducted with Konrad Beyreuther in which they discovered the proteolytic neuronal origin of the Aβ amyloid protein, which causes Alzheimer’s disease. This work has led to the continued development of diagnostics and therapeutic strategies and has been recognised by the receipt of many international awards."
To reach out to Prof Masters for discussion: https://florey.edu.au/researcher/colin-masters/
Research mentioned in the episode in order of appearance:
Masters CL, Kakulas BA, Alpers MP, Gajdusek DC, Gibbs CJ Jr. Preclinical lesions and their progression in the experimental spongiform encephalopathies (kuru and Creutzfeldt-Jakob disease) in primates. J Neuropathol Exp Neurol 1976; 35: 593-605.
Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, Beyreuther K. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci USA 1985; 82: 4245-4249.
Dyrks T, Weidemann A, Multhaup G, Salbaum JM, Lemaire H-G, Kang J, Müller-Hill B, Masters CL, Beyreuther K. Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease. EMBO J 1988; 7: 949-957.
Randy L. Buckner, Abraham Z. Snyder, Benjamin J. Shannon, Gina LaRossa, Rimmon Sachs, Anthony F. Fotenos, Yvette I. Sheline, William E. Klunk, Chester A. Mathis, John C. Morris, Mark A. Mintun. Molecular, Structural, and Functional Characterization of Alzheimer's Disease: Evidence for a Relationship between Default Activity, Amyloid, and Memory. Journal of Neuroscience 24 August 2005, 25 (34) 7709-7717; DOI: 10.1523/JNEUROSCI.2177-05.2005
Nakamura A, Kaneko N, Villemagne VL, Kato T, Doecke J, Doré V, Fowler C, Li QX, Martins R, Rowe C, Tomita T, Matsuzaki K, Ishii K[enji], Ishii K[anzunari], Arahata Y, Iwamoto S, Ito K, , Tanaka K, Masters CL, Yanagisawa K. High performance plasma amyloid-β biomarkers for Alzheimer’s disease. Nature 2018; 554: 249-254.
Burnham SC, Laws SM, Budgeon CA, Doré V, Porter T, Bourgeat P, Buckley RF, Murray K, Ellis KA, Turlack BA, Salvado O , Ames D, Martins RN, Rentz D, Masters CL, Rowe CC, Villemagne VL, for the Alzheimer’s Disease Neuroimaging Initiative, and the AIBL Research Group. Impact of APOE- ε4 carriage on the onset and rates of neocortical Aβ-amyloid deposition. Neurobiol Aging 2020; 95: 46-55.
Gu BJ, Huang X, Ou A, Rembach A, Fowler C, Avula PK, Horton A, Doecke JD, Villemagne VL, Macaulay SL, Maruff P, Fletcher EL, Guymer R, Wiley JS, Masters CL. The Australian Imaging, Biomarkers and Lifestyle (AIBL) Study. Innate phagocytosis by peripheral blood monocytes is altered in Alzhiemer’s disease. Acta Neuropath 2016; 132: 377-389.
"Over the last 40 years, his work is widely acknowledged as having had a major influence on Alzheimer’s disease research worldwide, particularly the collaborative studies conducted with Konrad Beyreuther in which they discovered the proteolytic neuronal origin of the Aβ amyloid protein, which causes Alzheimer’s disease. This work has led to the continued development of diagnostics and therapeutic strategies and has been recognised by the receipt of many international awards."
To reach out to Prof Masters for discussion: https://florey.edu.au/researcher/colin-masters/
Research mentioned in the episode in order of appearance:
Masters CL, Kakulas BA, Alpers MP, Gajdusek DC, Gibbs CJ Jr. Preclinical lesions and their progression in the experimental spongiform encephalopathies (kuru and Creutzfeldt-Jakob disease) in primates. J Neuropathol Exp Neurol 1976; 35: 593-605.
Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, Beyreuther K. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci USA 1985; 82: 4245-4249.
Dyrks T, Weidemann A, Multhaup G, Salbaum JM, Lemaire H-G, Kang J, Müller-Hill B, Masters CL, Beyreuther K. Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease. EMBO J 1988; 7: 949-957.
Randy L. Buckner, Abraham Z. Snyder, Benjamin J. Shannon, Gina LaRossa, Rimmon Sachs, Anthony F. Fotenos, Yvette I. Sheline, William E. Klunk, Chester A. Mathis, John C. Morris, Mark A. Mintun. Molecular, Structural, and Functional Characterization of Alzheimer's Disease: Evidence for a Relationship between Default Activity, Amyloid, and Memory. Journal of Neuroscience 24 August 2005, 25 (34) 7709-7717; DOI: 10.1523/JNEUROSCI.2177-05.2005
Nakamura A, Kaneko N, Villemagne VL, Kato T, Doecke J, Doré V, Fowler C, Li QX, Martins R, Rowe C, Tomita T, Matsuzaki K, Ishii K[enji], Ishii K[anzunari], Arahata Y, Iwamoto S, Ito K, , Tanaka K, Masters CL, Yanagisawa K. High performance plasma amyloid-β biomarkers for Alzheimer’s disease. Nature 2018; 554: 249-254.
Burnham SC, Laws SM, Budgeon CA, Doré V, Porter T, Bourgeat P, Buckley RF, Murray K, Ellis KA, Turlack BA, Salvado O , Ames D, Martins RN, Rentz D, Masters CL, Rowe CC, Villemagne VL, for the Alzheimer’s Disease Neuroimaging Initiative, and the AIBL Research Group. Impact of APOE- ε4 carriage on the onset and rates of neocortical Aβ-amyloid deposition. Neurobiol Aging 2020; 95: 46-55.
Gu BJ, Huang X, Ou A, Rembach A, Fowler C, Avula PK, Horton A, Doecke JD, Villemagne VL, Macaulay SL, Maruff P, Fletcher EL, Guymer R, Wiley JS, Masters CL. The Australian Imaging, Biomarkers and Lifestyle (AIBL) Study. Innate phagocytosis by peripheral blood monocytes is altered in Alzhiemer’s disease. Acta Neuropath 2016; 132: 377-389.
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