Biological resilience underpins healthy aging, and Anthony Molina, Ph.D., investigates how people resist, adapt to, and recover from age-related stressors. Molina defines three domains of resilience linked to aging and studies “life course” resilience using the Rancho Bernardo Study, a longitudinal cohort that starts in 1972 and tracks cognitive, sensory, physical function and comorbidities. His group analyzes trajectory scores from tasks such as the trail-making test and examines thousands of blood molecules to identify patterns that distinguish exceptionally resilient participants. Laboratory experiments show how age-related molecular profiles relate to mitochondrial function and ATP production. Molina’s team also tests behavioral and nutritional interventions in rigorously designed clinical studies, combining molecular biomarkers of biological age with measures of physical performance, cognition, sensory abilities, and mental well-being. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40958]

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