The Guardians of the TWiV-o-verse discuss the process of codon deoptimization for the production of experimental infectious attenuated viral vaccines, and how a respiratory syncytial virus with 619 base changes was rescued by genomes with very large internal deletions. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode NIDO 2021 Symposium ASV hosts free COVID-19 Vaccine Education Town Halls (register here) Research position in Spindler laboratory Attenuation of poliovirus by codon deoptimization (Science) Rescue of codon-deoptimized RSV by large deletions (PNAS) Letters read on TWiV 740 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Let us now praise tiny ants Brianne – Small-school science Rich – Smallpox 'virus squads' and the mandatory vaccinations upheld by the Supreme Court Kathy – The Transcontinental Burrito Tunnel Vincent – Glass music by Robert Tiso Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]

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