Ori, Jason, and Vincent discuss the use of antibodies to neutralize amyloid-β seeds before their deposition becomes detectable in transgenic mice, and the finding that the preclinical phase of Alzheimer‘s disease may be a late manifestation of earlier pathogenic seed formation. Hosts: Ori Lieberman, Jason Shepherd, and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Reducing Alzheimer-like pathology in mice (Nat Neurosci) Letters read on TWiN 13 Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to [email protected]

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