Nels and Vincent discuss how evolution of changes in stop codon assignment might occur, and a novel mechanism for altering the meaning of translation stop codons discovered in a trypanosomatid with the apropos name, Blastocrithidia nonstop. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiEVO Links for this episode •Join the MicrobeTV Discord server •Novel stop codon reassignment mechanisms (Nature) Science Picks Nels – Protein Synthesis: An epic on the cellular level  Vincent – Widespread stop-codon recoding in bacteriophages may regulate translation of lytic genes discussed on TWiM 277 Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to [email protected]

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