Listen "Tylenol and Autism?"
Episode Synopsis
Your body processes acetaminophen via two distinct pathways:Phase 2 metabolism (the safe route): Your liver adds molecules through glucuronidation and sulfation - making it water-soluble so you can pee it out safely.Phase 1 metabolism (the toxic route): Your body tries to "burn" the acetaminophen through cytochrome P450 oxidation... creating NAPQI - a highly reactive molecule that depletes glutathione (your master antioxidant) and damages mitochondria.PMID links Cord blood study: Mothers divided into 3 groups by acetaminophen levels at birth. They found a 4x increased risk of Autism with higher exposure. (PMID: 31664451)Animal study (2014): Two doses before day 10 caused permanent brain changes; males more affected. (PMID: 24361869)Neuronal death: Even non-lethal doses kill brain cells in developing animals. (PMID: 21170329)Systematic review (2025): 46 studies - the stronger the study design, the stronger the association. (PMID: 40804730) What about the studies "DEBUNKING" it?!”Those studies are incredibly misleading….Let’s consider the biggest one, which followed 2.5 million Swedish births. They compared siblings - one exposed in utero, one not. When they did this, the autism association disappeared. (PMID: 38592388)
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