In this episode of The Pathology Report, host Dr Leo Lam is joined by A/Prof Vanessa Tyrrell, Program Director of the Zero Childhood Cancer National Precision Medicine Program (ZERO), to discuss the development and application of precision medicine in the context of childhood cancer.A/Prof Tyrrell provides a practical overview of how genomics and integrated multi-omics approaches are being used to improve outcomes for children with cancer in Australia.She explains the origins and growth of the Zero Childhood Cancer Program, from when it began in 2015 for high-risk patients to its expansion nationwide, and how comprehensive testing, including whole genome and transcriptome sequencing, methylation profiling, and laboratory-based cancer models and high throughput drug screening, is now informing both prognosis and targeted therapy selection.A/Prof Tyrrell discusses the clinical impact of precision medicine, from risk stratification to personalised treatment pathways, including emerging roles for immunotherapy and RNA vaccines. In this, she emphasises the importance of multidisciplinary collaboration, clinician engagement and addressing the psychosocial impact on children, families and healthcare teams.Looking ahead, A/Prof Tyrrell shares her vision for the next decade where precision medicine could move from research into routine care, becoming an integral part of health systems worldwide.RCPA MembersThis podcast is an RCPA-endorsed CPD activity. Each episode gives you an opportunity to gain CPD hours in three easy steps:Step 1. Listen or watch the podcast here, on your favourite podcast channel or on YouTubeStep 2. To claim your CPD hours, please complete and pass this short online quizStep 3. Sit back and let us load your CPD hours into your CPD profile for youThe Pathology Report is produced by the Royal College of Pathologists of Australasia and is part of the Talking HealthTech Podcast Network.Learn more about the RCPA at rcpa.edu.au and discover other shows in the network at talkinghealthtech.com/podcast/network.

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