Can we really spot the signs of dementia 20 years before symptoms appear?
In this episode, host Leon Rossiter and co-host Stephen sit down with leading psychiatrist and dementia researcher Dr. Ivan Koychev to explore how science is rewriting what we know about brain health and prevention.
Dr. Koychev, based at Imperial College London, dives into cutting-edge research on early risk detection, the potential of blood biomarkers, and why repurposing diabetes medications could be a game-changer in the fight against Alzheimer’s. The team also explores innovative tools like the Five Lives app, personalized risk assessments, and how lifestyle changes could prevent up to 40% of dementia cases. Later in the episode, they discuss what life can look like after a diagnosis—touching on the power of learning, community, and therapies that keep the mind engaged.
Whether you’re concerned about your own risk, supporting a loved one, or simply staying informed, this episode is packed with practical advice and fresh hope for the future of dementia care.
Resources in this episode: 1. Great Minds (Brain Health Volunteer Register) What is it? A register where people can sign up to contribute to and participate in dementia research, including cognitive tests, genetic screening, and possible involvement in clinical trials. Website: https://www.greatmindsfordementia.uk 2. Five Lives App What is it? A free app designed to help people assess their risk of dementia, understand modifiable risk factors, and receive recommendations on lifestyle changes. Website: https://www.fivelives.health/ (Available on both the App Store and Google Play) 3. Lancet Commission Paper on Dementia Prevention What is it? Referenced in the discussion as the source suggesting that 40%-50% of dementia cases may be preventable due to modifiable risk factors. Link to the most recent paper: https://www.thelancet.com/commissions...

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